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Erythrocytes or red blood cells (RBCs) are the cells in the circulation that carry oxygen to and remove carbon dioxide from the tissues throughout the body. They are produced in the bone marrow in response to erythropoietin where they transition through six stages over a seven day period. When they are released into the circulation, their nucleus has been extruded and they measure 6-8 microns in diameter. The lifespan of RBCs is about 120 days. When the RBC ages the cell membrane becomes less pliable and tears as they cell travels through the micro vessels of the body. The damaged RBCs are removed from the circulation by the spleen. Variations in number, shape and size of RBCs are indicative of many diseases and disorders. 1
In the OMOP vocabulary 8786 is a Standard Concept that represents the unit per high power field (HPF)
0
200.00
In the OMOP vocabulary 8647 is a Standard Concept that represents the unit per microliter (uL or mcL)
300000
10000000.00
Red blood count measured in high power field (RBC/HPF) is typically done during a urinalysis to determine whether or not there are RBCs in the urine. A person may have no RBCs in their urine, so 0 is a plausible low value. According to this hematuria study 2, people with gross hematuria can greater than 50 red blood cells per high-power field [RBCs/HPF], with some greater than 100 RBC/HPF 3. Given that, a tentative value of 200 is chosen as a plausible high value when using HPF as the unit of measurement.
When the unit of measurement is number of cells per microliter (RBC/uL or RBC/mcL), the normal range for adults and children is from ~4 to ~6 million cells per microliter. Studies on people with polycythemia have included those with RBC counts as high as 9 million cells per mcL 4. More research is necessary to determine a biologically plausible high value, but given the data from 4, a value of 10 million rbc/uL is suggested as an initial plausible high value. Biologically plausible low values were also difficult to ascertain. In a study on red blood cells counts of patients with primary liver cancer, the low range of rbc was 380,000 per mcl. 5 Given that, we have chosen a initial plausibly low value of 300,000.