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DV.7.1 with ORF1a:K3353R (>80 seq. Mainly Israel and Spain) #559

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oobb45729 opened this issue Aug 5, 2023 · 3 comments
Closed

DV.7.1 with ORF1a:K3353R (>80 seq. Mainly Israel and Spain) #559

oobb45729 opened this issue Aug 5, 2023 · 3 comments
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FLip = S:L455F / S:F456L Mutations outside spike To be proposed Green light for proposal

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@oobb45729
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oobb45729 commented Aug 5, 2023

It seems that this DV.7.1 sublineage with a Beta-defining mutation ORF1a:K3353R has taken root in Israel.
https://cov-spectrum.org/explore/World/AllSamples/Past6M/variants?variantQuery=nextcladePangoLineage%3ADV.7*%26%21S%3AL455L%26%21S%3AF456F%26ORF1a%3AK3353R&
1
2
https://nextstrain.org/fetch/genome.ucsc.edu/trash/ct/subtreeAuspice1_genome_39903_eb3cc0.json?c=gt-ORF1ab_3353&label=id:node_7476474

Nuc Query: A10323G,G22927T,G25606A finds 77 as September 1.

@oobb45729 oobb45729 changed the title DV.7.1 with ORF1a:K3353R (35 seq. Mainly Israel and Spain) DV.7.1 with ORF1a:K3353R (36 seq. Mainly Israel and Spain) Aug 7, 2023
@oobb45729 oobb45729 changed the title DV.7.1 with ORF1a:K3353R (36 seq. Mainly Israel and Spain) DV.7.1 with ORF1a:K3353R (38 seq. Mainly Israel and Spain) Aug 15, 2023
@oobb45729 oobb45729 changed the title DV.7.1 with ORF1a:K3353R (38 seq. Mainly Israel and Spain) DV.7.1 with ORF1a:K3353R (39 seq. Mainly Israel and Spain) Aug 19, 2023
@oobb45729 oobb45729 changed the title DV.7.1 with ORF1a:K3353R (39 seq. Mainly Israel and Spain) DV.7.1 with ORF1a:K3353R (>60 seq. Mainly Israel and Spain) Aug 24, 2023
@oobb45729 oobb45729 changed the title DV.7.1 with ORF1a:K3353R (>60 seq. Mainly Israel and Spain) DV.7.1 with ORF1a:K3353R (>80 seq. Mainly Israel and Spain) Aug 31, 2023
@FedeGueli FedeGueli added combo It has a couple of mutation in RBD FLip = S:L455F / S:F456L S:456 S:455 and removed combo It has a couple of mutation in RBD labels Sep 2, 2023
@FedeGueli
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sorry @oobb45729 i missed your updates of this one without the proper label. . Consider that Orf1a:K3353R is very homoplasic. I prefer to wait a bit to evaluate how it co ares with the other newcoming lineages. i saw @aviczhl2 found a new sublineage of it. We will monitor both together

@FedeGueli
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98 as 04/09 , 12 of them collected in Israel during august representing a 2-2,5% of sequences colleced there after august 1.
Please propose it.

@FedeGueli
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Thank you

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Labels
FLip = S:L455F / S:F456L Mutations outside spike To be proposed Green light for proposal
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