filter on node attributes #174

andrewsu · 2021-05-10T19:19:41Z

Node attributes on chemical compounds indicate drug approval status. Clearly we could filter based on these attributes post-query, and a helper tool to do this may be quite useful in the short term. But it would also be good to allow filtering on these node attributes as part of the query. Filters would presumably be based on EITHER the value of a certain attribute OR the existence of an attribute.

More details

This query gives all compounds related to SLC2A1 / GLUT1 (Updated to TRAPI v1.1 2021-06-08):

{
    "message": {
        "query_graph": {
            "nodes": {
                "n0": {
                    "categories": ["biolink:Gene"],
                    "ids": ["NCBIGene:6513"]
                },
                "n1": {
                    "categories": ["biolink:ChemicalSubstance"]
                }
            },
            "edges": {
                "e01": {
                    "subject": "n0",
                    "object": "n1",
                    "predicate": "biolink:physically_interacts_with"
                }
            }
        }
    }
}

one of the results is pasted below -- several attributes seem to indicate FDA approval status, including chembl_max_phase, drugbank_groups, fda_epc_pharmacology_class

               "CHEBI:40279": {
                    "category": "biolink:ChemicalSubstance",
                    "name": "ALLOPURINOL",
                    "attributes": [
                        {
                            "name": "equivalent_identifiers",
                            "value": [
                                "CHEMBL.COMPOUND:CHEMBL1467",
                                "CHEMBL.COMPOUND:CHEMBL1200477",
                                "DRUGBANK:DB00437",
                                "PUBCHEM.COMPOUND:135401907",
                                "PUBCHEM.COMPOUND:2094",
                                "CHEBI:40279",
                                "UMLS:C0002144",
                                "MESH:D000493",
                                "UNII:428673RC2Z",
                                "UNII:63CZ7GJN5I",
                                "INCHIKEY:OFCNXPDARWKPPY-UHFFFAOYSA-N",
                                "INCHI:InChI=1S/C5H4N4O/c10-5-3-1-8-9-4(3)6-2-7-5/h1-2H,(H2,6,7,8,9,10)",
                                "LINCS:LSM-5919",
                                "name:ALLOPURINOL",
                                "name:Allopurinol",
                                "name:allopurinol"
                            ],
                            "type": "biolink:id"
                        },
                        {
                            "name": "num_source_nodes",
                            "value": 1,
                            "type": "bts:num_source_nodes"
                        },
                        {
                            "name": "num_target_nodes",
                            "value": 0,
                            "type": "bts:num_target_nodes"
                        },
                        {
                            "name": "source_qg_nodes",
                            "value": [
                                "n0"
                            ],
                            "type": "bts:source_qg_nodes"
                        },
                        {
                            "name": "target_qg_nodes",
                            "value": [],
                            "type": "bts:target_qg_nodes"
                        },
                        {
                            "name": "chembl_max_phase",
                            "value": [
                                "4"
                            ],
                            "type": "bts:chembl_max_phase"
                        },
                        {
                            "name": "chembl_molecule_type",
                            "value": [
                                "Small molecule"
                            ],
                            "type": "bts:chembl_molecule_type"
                        },
                        {
                            "name": "drugbank_drug_category",
                            "value": [
                                "Antigout Preparations",
                                "Antimetabolites",
                                "Antioxidants",
                                "BCRP/ABCG2 Substrates",
                                "Drugs that are Mainly Renally Excreted",
                                "Enzyme Inhibitors",
                                "Free Radical Scavengers",
                                "Heterocyclic Compounds, Fused-Ring",
                                "Musculo-Skeletal System",
                                "OAT3/SLC22A8 Substrates",
                                "Preparations Inhibiting Uric Acid Production",
                                "Protective Agents",
                                "Purines",
                                "Uricosuric Agents",
                                "Xanthine Oxidase Inhibitors"
                            ],
                            "type": "bts:drugbank_drug_category"
                        },
                        {
                            "name": "drugbank_taxonomy_class",
                            "value": [
                                "Pyrazolopyrimidines"
                            ],
                            "type": "bts:drugbank_taxonomy_class"
                        },
                        {
                            "name": "drugbank_groups",
                            "value": [
                                "approved"
                            ],
                            "type": "bts:drugbank_groups"
                        },
                        {
                            "name": "drugbank_kingdom",
                            "value": [
                                "Organic compounds"
                            ],
                            "type": "bts:drugbank_kingdom"
                        },
                        {
                            "name": "drugbank_superclass",
                            "value": [
                                "Organoheterocyclic compounds"
                            ],
                            "type": "bts:drugbank_superclass"
                        },
                        {
                            "name": "contraindications",
                            "value": [
                                "Disease of liver",
                                "Chronic heart failure",
                                "Hypersensitivity angiitis",
                                "Dehydration",
                                "Impaired renal function disorder"
                            ],
                            "type": "bts:contraindications"
                        },
                        {
                            "name": "indications",
                            "value": [
                                "Calcium renal calculus",
                                "Gout",
                                "Uric Acid Nephropathy Gout",
                                "Articular gout",
                                "Hyperuricemia",
                                "Chemotherapy-Induced Hyperuricemia",
                                "Uric acid renal calculus",
                                "Recurrent Calcium Renal Calculi"
                            ],
                            "type": "bts:indications"
                        },
                        {
                            "name": "mesh_pharmacology_class",
                            "value": [
                                "Antimetabolites",
                                "Antioxidants",
                                "Antirheumatic Agents",
                                "Enzyme Inhibitors",
                                "Free Radical Scavengers",
                                "Gout Suppressants",
                                "Noxae"
                            ],
                            "type": "bts:mesh_pharmacology_class"
                        },
                        {
                            "name": "fda_epc_pharmacology_class",
                            "value": [
                                "Xanthine Oxidase Inhibitor"
                            ],
                            "type": "bts:fda_epc_pharmacology_class"
                        }
                    ]

The text was updated successfully, but these errors were encountered:

andrewsu · 2021-06-07T22:34:26Z

In TRAPI 1.1, message.query_graph is of type QueryGraph (link) which has properties for nodes (of type QNode) and edges (of type QEdge). Both QNodes and QEdges allows the specification of a constraint property (of type QueryConstraint link). The constraint described above (filter for FDA-approved drugs) would look like this (taken from https://github.com/NCATSTranslator/minihackathons/blob/main/2021-12_demo/workflowA/EGFR_advanced.json and referenced in NCATSTranslator/minihackathons#164):

{
    "message": {
        "query_graph": {
            "nodes": {
                "n0": {
                    "categories": [
                        "biolink:ChemicalSubstance"
                    ],
                    "name": "Chemical Substance",
                    "constraints": [
                        {
                            "id": "biolink:highest_FDA_approval_status",
                            "name": "highest FDA approval status",
                            "operator": "==",
                            "value": "regular approval"
                        }
                    ]
                },
                "n1": {
                    "name": "EGFR",
                    "ids": [
                        "NCBIGene:1956"
                    ]
                }
            },
            "edges": {
                "e0": {
                    "subject": "n0",
                    "object": "n1",
                    "predicates": [
                        "biolink:decreases_abundance_of",
                        "biolink:decreases_activity_of",
                        "biolink:decreases_expression_of",
                        "biolink:decreases_synthesis_of",
                        "biolink:increases_degradation_of",
                        "biolink:disrupts",
                        "biolink:entity_negatively_regulates_entity"
                    ]
                }
            }
        }
    }
}

Based on that, it appears we need to change bts:chembl_max_phase to biolink:highest_FDA_approval_status in our smartAPI mapping file?

colleenXu · 2021-09-24T19:58:46Z

update for TRAPI v1.2. I think the query constraints work the same as specified above. I updated the query below (maybe use SmallMolecule or ChemicalEntity?):

{
    "message": {
        "query_graph": {
            "nodes": {
                "n0": {
                    "categories": [
                        "biolink:ChemicalEntity"
                    ],
                    "constraints": [
                        {
                            "id": "biolink:highest_FDA_approval_status",
                            "name": "highest FDA approval status",
                            "operator": "==",
                            "value": "regular approval"
                        }
                    ]
                },
                "n1": {
                    "categories": [
                        "biolink:Gene"
                    ],
                    "ids": [
                        "NCBIGene:1956"
                    ]
                }
            },
            "edges": {
                "e0": {
                    "subject": "n0",
                    "object": "n1"
                }
            }
        }
    }
}

colleenXu · 2021-10-09T06:17:31Z

This is dependent on #302 and its PRs. I think it's addressed by this PR: biothings/bte_trapi_query_graph_handler#45

colleenXu · 2021-10-09T06:49:25Z

@marcodarko some feedback on biothings/bte_trapi_query_graph_handler#45:

I only took a quick look based on this query, which worked as-expected compared to its unconstrained version:

Click for query

{
    "message": {
        "query_graph": {
            "edges": {
                "e01": {
                    "subject": "n0",
                    "object": "n1"
                }
            },
            "nodes": {
                "n0": {
                    "ids": ["MONDO:0019391"],
                    "categories": ["biolink:Disease"]
                },
                "n1": {
                    "categories": ["biolink:Gene"],
                    "constraints": [
                        {
                            "name": "type_of_gene",
                            "operator": "==",
                            "value": "protein-coding"
                        }
                    ]
                }
            }
        }
    }
}

It looks like this implementation does not fully follow the specifications here. For example, I can run a constraint without an "id" field (the query above) and it still works, but the fields id / name / operator / value are all required in the spec.
Based on the specification linked above, the "id" field is what should be compared to the keys we have for the node attributes. When we can, we should make the keys match the biolink model...

Also, there is some complicated and unclear behavior in the specification regarding the operators and values...I think this involves some discussion with @andrewsu...

For example, many of our node attributes are actually lists (like drugbank_groups, drugbank_drug_category above). In this situation, how are node constraints meant to be specified?
How much behavior around the operators are we going to support? There's a lot....including different behavior depending on whether the node constraint's value is a list or not, whether the not field is True...

andrewsu · 2021-10-12T17:17:55Z

Example query: https://github.com/NCATSTranslator/minihackathons/blob/main/2021-12_demo/workflowA/future/A.2_RHOBTB2_twohop_constrained.json

andrewsu · 2021-10-12T17:27:44Z

For now, let's only deal with single-value constraints. We also need to deal with mismatch between chembl.max_phase in mychem.info and FDA_approval_status_enum at https://github.com/biolink/biolink-model/blob/master/biolink-model.yaml#L239. So instead of the example query posted immediately above, for now, test on this (replacing "regular approval" with "4"):

{
    "message": {
        "query_graph": {
            "edges": {
                "e01": {
                    "object": "n0",
                    "subject": "n1",
                    "predicates": [
                        "biolink:entity_regulates_entity",
                        "biolink:genetically_interacts_with"
                    ]
                },
                "e02": {
                    "object": "n1",
                    "subject": "n2",
                    "predicates": [
                        "biolink:related_to"
                    ]
                }
            },
            "nodes": {
                "n0": {
                    "ids": [
                        "NCBIGene:23221"
                    ],
                    "categories": [
                        "biolink:Gene"
                    ]
                },
                "n1": {
                    "categories": [
                        "biolink:Gene"
                    ]
                },
                "n2": {
                    "categories": [
                        "biolink:SmallMolecule"
                    ] ,
                    "constraints": [
                        {
                            "id": "biolink:highest_FDA_approval_status",
                            "name": "highest FDA approval status",
                            "operator": "==",
                            "value": "4"
                        }
                    ]
                }
            }
        }
    }
}

colleenXu · 2021-10-29T03:47:09Z

Note that the following queries are working as-expected. However, I am currently using a local environ that excludes all pending biothings APIs except clinical risk kp api / multiomics wellness api...

Modified version of A.2_RHOBTB2_twohop_constrained

Modified from this

{
    "message": {
        "query_graph": {
            "edges": {
                "e01": {
                    "subject": "n1",
                    "object": "n0",
                    "predicates": [
                        "biolink:entity_regulates_entity",
                        "biolink:genetically_interacts_with"
                    ]
                },
                "e02": {
                    "subject": "n2",
                    "object": "n1",
                    "predicates": ["biolink:related_to"]
                }
            },
            "nodes": {
                "n0": {
                    "ids": ["NCBIGene:23221"],
                    "categories": ["biolink:Gene"]
                },
                "n1": {
                    "categories": ["biolink:Gene"]
                },
                "n2": {
                    "categories": ["biolink:SmallMolecule"] ,
                    "constraints": [
                        {
                            "id": "biolink:highest_FDA_approval_status",
                            "name": "highest FDA approval status",
                            "operator": "==",
                            "value": 4
                        }
                    ]
                }
            }
        }
    }
}

Modified version of A.9_EGFR_advanced

Modified from this

{
    "message": {
        "query_graph": {
            "nodes": {
                "n0": {
                    "categories": ["biolink:SmallMolecule"],
                    "name": "Small Molecule",
                    "constraints": [
                        {
                            "id": "biolink:highest_FDA_approval_status",
                            "name": "highest FDA approval status",
                            "operator": "==",
                            "value": 4
                        }
                    ]
                },
                "n1": {
                    "name": "EGFR",
                    "ids": ["NCBIGene:1956"]
                }
            },
            "edges": {
                "e0": {
                    "subject": "n0",
                    "object": "n1",
                    "predicates": [
                        "biolink:decreases_abundance_of",
                        "biolink:decreases_activity_of",
                        "biolink:decreases_expression_of",
                        "biolink:decreases_synthesis_of",
                        "biolink:increases_degradation_of",
                        "biolink:disrupts",
                        "biolink:entity_negatively_regulates_entity"
                    ]
                }
            }
        }
    }
}

With the removal of pending apis, we currently cannot do the following query (no metaKG edges to do the operation with negatively regulates...

Modified version of A.2a_expanded_RHOBTB2_twohop_constrained

Modified from this

{
    "message": {
        "query_graph": {
            "edges": {
                "e01": {
                    "object": "n0",
                    "subject": "n1",
                    "predicates": [
                        "biolink:entity_negatively_regulates_entity"
                    ]
                },
                "e02": {
                    "object": "n1",
                    "subject": "n2",
                    "predicates":  [
                        "biolink:increases_abundance_of", 
                        "biolink:increases_expression_of", 
                        "biolink:increases_stability_of", 
                        "biolink:increases_uptake_of", 
                        "biolink:decreases_degradation_of", 
                        "biolink:increases_secretion_of", 
                        "biolink:increases_metabolic_processing_of", 
                        "biolink:increases_folding_of", 
                        "biolink:increases_localization_of", 
                        "biolink:increases_synthesis_of", 
                        "biolink:increases_response_to", 
                        "biolink:increases_splicing_of", 
                        "biolink:increases_mutation_rate_of", 
                        "biolink:increases_transport_of", 
                        "biolink:increases_activity_of", 
                        "biolink:increases_molecular_modification_of", 
                        "biolink:increases_molecular_interaction"
                    ]
                }
            },
            "nodes": {
                "n0": {
                    "ids": [
                        "NCBIGene:23221"
                    ],
                    "categories": [
                        "biolink:Gene"
                    ]
                },
                "n1": {
                    "categories": [
                        "biolink:Gene"
                    ]
                },
                "n2": {
                    "categories": [
                        "biolink:SmallMolecule"
                    ],
                    "constraints": [
                        {
                            "id": "biolink:highest_FDA_approval_status",
                            "name": "highest FDA approval status",
                            "operator": "==",
                            "value": 4
                        }
                    ]
                }
            }
        }
    }
}

colleenXu · 2021-10-29T04:02:40Z

@marcodarko note that we may want to change the node attribute name from biolink:"highest_FDA_approval_status" to "biolink:"drug_regulatory_status_world_wide".

@andrewsu please confirm whether we want to make this change or not...

colleenXu · 2021-10-29T04:04:14Z

@marcodarko also FYI the discussion here NCATSTranslator/ReasonerAPI#298. It's difficult to know how to implement constraints when the node attribute's value is actually a list (not an int or string)....which is the case for most of the node attributes described above.

andrewsu · 2021-10-29T04:49:44Z

@marcodarko note that we may want to change the node attribute name from biolink:"highest_FDA_approval_status" to "biolink:"drug_regulatory_status_world_wide".

@andrewsu please confirm whether we want to make this change or not...

Yes, the mapping of chembl.max_phase should now go to biolink:drug_regulatory_status_world_wide

colleenXu · 2021-10-29T06:15:30Z

Just tried again with a full api list and the following queries ran and looked like they worked compared to the queries without the constraint:

A.2_RHOBTB2_twohop_constrained
A.2a_expanded_RHOBTB2_twohop_constrained
A.9_EGFR_advanced

marcodarko · 2021-10-29T14:22:07Z

@colleenXu @andrewsu great thank you both, I'll update the PRs

colleenXu · 2021-10-29T18:50:06Z

Updating the queries to use biolink:drug_regulatory_status_world_wide:

Modified version of A.2_RHOBTB2_twohop_constrained

Modified from this

{
    "message": {
        "query_graph": {
            "edges": {
                "e01": {
                    "subject": "n1",
                    "object": "n0",
                    "predicates": [
                        "biolink:entity_regulates_entity",
                        "biolink:genetically_interacts_with"
                    ]
                },
                "e02": {
                    "subject": "n2",
                    "object": "n1",
                    "predicates": ["biolink:related_to"]
                }
            },
            "nodes": {
                "n0": {
                    "ids": ["NCBIGene:23221"],
                    "categories": ["biolink:Gene"]
                },
                "n1": {
                    "categories": ["biolink:Gene"]
                },
                "n2": {
                    "categories": ["biolink:SmallMolecule"] ,
                    "constraints": [
                        {
                            "id": "biolink:drug_regulatory_status_world_wide",
                            "name": "max phase",
                            "operator": "==",
                            "value": 4
                        }
                    ]
                }
            }
        }
    }
}

Modified version of A.9_EGFR_advanced

Modified from this

{
    "message": {
        "query_graph": {
            "nodes": {
                "n0": {
                    "categories": ["biolink:SmallMolecule"],
                    "name": "Small Molecule",
                    "constraints": [
                        {
                            "id": "biolink:drug_regulatory_status_world_wide",
                            "name": "max phase",
                            "operator": "==",
                            "value": 4
                        }
                    ]
                },
                "n1": {
                    "name": "EGFR",
                    "ids": ["NCBIGene:1956"]
                }
            },
            "edges": {
                "e0": {
                    "subject": "n0",
                    "object": "n1",
                    "predicates": [
                        "biolink:decreases_abundance_of",
                        "biolink:decreases_activity_of",
                        "biolink:decreases_expression_of",
                        "biolink:decreases_synthesis_of",
                        "biolink:increases_degradation_of",
                        "biolink:disrupts",
                        "biolink:entity_negatively_regulates_entity"
                    ]
                }
            }
        }
    }
}

With the removal of pending apis, we currently cannot do the following query (no metaKG edges to do the operation with negatively regulates...

Modified version of A.2a_expanded_RHOBTB2_twohop_constrained

Modified from this

{
    "message": {
        "query_graph": {
            "edges": {
                "e01": {
                    "object": "n0",
                    "subject": "n1",
                    "predicates": [
                        "biolink:entity_negatively_regulates_entity"
                    ]
                },
                "e02": {
                    "object": "n1",
                    "subject": "n2",
                    "predicates":  [
                        "biolink:increases_abundance_of", 
                        "biolink:increases_expression_of", 
                        "biolink:increases_stability_of", 
                        "biolink:increases_uptake_of", 
                        "biolink:decreases_degradation_of", 
                        "biolink:increases_secretion_of", 
                        "biolink:increases_metabolic_processing_of", 
                        "biolink:increases_folding_of", 
                        "biolink:increases_localization_of", 
                        "biolink:increases_synthesis_of", 
                        "biolink:increases_response_to", 
                        "biolink:increases_splicing_of", 
                        "biolink:increases_mutation_rate_of", 
                        "biolink:increases_transport_of", 
                        "biolink:increases_activity_of", 
                        "biolink:increases_molecular_modification_of", 
                        "biolink:increases_molecular_interaction"
                    ]
                }
            },
            "nodes": {
                "n0": {
                    "ids": [
                        "NCBIGene:23221"
                    ],
                    "categories": [
                        "biolink:Gene"
                    ]
                },
                "n1": {
                    "categories": [
                        "biolink:Gene"
                    ]
                },
                "n2": {
                    "categories": [
                        "biolink:SmallMolecule"
                    ],
                    "constraints": [
                        {
                            "id": "biolink:drug_regulatory_status_world_wide",
                            "name": "max phase",
                            "operator": "==",
                            "value": 4
                        }
                    ]
                }
            }
        }
    }
}

colleenXu · 2021-11-03T20:02:14Z

Closing because it's been deployed on prod.

Next steps are @andrewsu discussing whether the demo queries can use our node constraint modifications: #174 (comment)

colleenXu · 2022-06-06T21:28:25Z

noting that only == was implemented (so I can't do <= or >=)... #380

colleenXu · 2022-06-06T21:35:29Z

I'm not sure if this is still working...the following query is hitting a TypeError:

Query:

{
    "message": {
        "query_graph": {
            "nodes": {
                "disease": {
                    "ids":["MONDO:0004975"],
                    "categories":["biolink:Disease"],
                    "names": "Alzheimers"
               },
                "nA": {
                    "categories":["biolink:PhenotypicFeature"]
                },
                "drug": {
                    "categories":["biolink:ChemicalEntity"],
                    "constraints": [
                        {
                            "id": "biolink:drug_regulatory_status_world_wide",
                            "name": "max phase",
                            "operator": "==",
                            "value": 2
                        }
                    ]
                }
            },
            "edges": {
                "eA": {
                    "subject": "disease",
                    "object": "nA",
                    "predicates": ["biolink:has_phenotype"]
                },
                "eB": {
                    "subject": "nA",
                    "object": "drug",
                    "predicates": ["biolink:treated_by"]
                }
            }
        }
    }
}

Console logs:

  bte:call-apis:query id annotation completes +3s
  bte:call-apis:query qEdge queries complete in 6s +0ms
  bte:biothings-explorer-trapi:batch_edge_query APIEdges are successfully queried.... +9s
  bte:biothings-explorer-trapi:batch_edge_query Filtering out any "undefined" items in (1555) records +0ms
  bte:biothings-explorer-trapi:batch_edge_query Total number of records is (1496) +0ms
  bte:biothings-explorer-trapi:batch_edge_query Start to update nodes... +0ms
  bte:biothings-explorer-trapi:batch_edge_query Update nodes completed! +0ms
  bte:biothings-explorer-trapi:QueryExecutionEdge (6) Storing records... +9s
  bte:biothings-explorer-trapi:QueryExecutionEdge (6) Applying Node Constraints to 1496 records. +0ms
  bte:biothings-explorer-trapi:QueryExecutionEdge Node (object) constraints: [{"id":"biolink:drug_regulatory_status_world_wide","name":"max phase","operator":"==","value":2}] +0ms
  bte:biothings-explorer-trapi:error_handler TypeError: Cannot read properties of undefined (reading '0')
  bte:biothings-explorer-trapi:error_handler     at QueryExecutionEdge.meetsConstraint (/Users/colleenxu/Desktop/bte-trapi-workspace/packages/@biothings-explorer/query_graph_handler/built/query_execution_edge.js:294:43)
  bte:biothings-explorer-trapi:error_handler     at QueryExecutionEdge.applyNodeConstraints (/Users/colleenxu/Desktop/bte-trapi-workspace/packages/@biothings-explorer/query_graph_handler/built/query_execution_edge.js:274:33)
  bte:biothings-explorer-trapi:error_handler     at QueryExecutionEdge.storeRecords (/Users/colleenxu/Desktop/bte-trapi-workspace/packages/@biothings-explorer/query_graph_handler/built/query_execution_edge.js:426:14)
  bte:biothings-explorer-trapi:error_handler     at TRAPIQueryHandler.query (/Users/colleenxu/Desktop/bte-trapi-workspace/packages/@biothings-explorer/query_graph_handler/built/index.js:245:27)
  bte:biothings-explorer-trapi:error_handler     at runMicrotasks (<anonymous>)
  bte:biothings-explorer-trapi:error_handler     at processTicksAndRejections (node:internal/process/task_queues:96:5)
  bte:biothings-explorer-trapi:error_handler     at async task (/Users/colleenxu/Desktop/bte-trapi-workspace/packages/@biothings-explorer/bte-trapi/src/routes/v1/query_v1.js:34:13)
  bte:biothings-explorer-trapi:error_handler     at async /Users/colleenxu/Desktop/bte-trapi-workspace/packages/@biothings-explorer/bte-trapi/src/controllers/threading/threadHandler.js:93:38 +3m

andrewsu mentioned this issue Aug 4, 2021

Implementation constraint queries NCATSTranslator/minihackathons#164

Open

andrewsu mentioned this issue Aug 26, 2021

BTE no results Workflow A.9 NCATSTranslator/minihackathons#209

Closed

andrewsu added this to the 2021-11 feature/code freeze milestone Oct 20, 2021

andrewsu assigned marcodarko Oct 20, 2021

andrewsu mentioned this issue Oct 21, 2021

add ability to filter out promiscuous intermediate nodes #330

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colleenXu closed this as completed Nov 3, 2021

colleenXu mentioned this issue Dec 22, 2021

clear language / documentation of vocab + data structures #379

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colleenXu mentioned this issue Jun 6, 2022

implement "creative/inferred mode" for "what drugs may treat disease X" query #449

Closed

colleenXu mentioned this issue Jul 6, 2022

TRAPI 1.2 -> 1.3 migration #450

Closed

colleenXu mentioned this issue Aug 10, 2022

discuss TRAPI 1.3 constraints: 3 types #482

Open

colleenXu mentioned this issue Oct 6, 2022

Check Qnode/Qedge properties biothings/bte_trapi_query_graph_handler#125

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filter on node attributes #174

filter on node attributes #174

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colleenXu commented Jun 6, 2022

filter on node attributes #174

filter on node attributes #174

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