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Update README.md
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yil8 committed May 21, 2014
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Expand Up @@ -79,8 +79,7 @@ PyLOH is composed of three modules:
* `preprocess`. Preprocess the reads aliments of paired normal-tumor samples in BAM format and produce the paired counts file,
preprocessed segments file and preprocessed BAF heat map file as output.

* `run_model`. Take the paired counts file and preprocessed segments file as input, estimate tumor purity, the copy number and the
allele type of each segment.
* `run_model`. Take the paired counts file and preprocessed segments file as input, estimate tumor purity, the copy number of each segment.

* `postprocess`. Take the preprocessed BAF heat map file as input and plot the BAF heat map for each segment as output.

Expand Down Expand Up @@ -177,12 +176,12 @@ column in a *.PyLOH.segments file is listed here:
| start | Start position of the segment |
| end | End position of the segment |
| normal_reads_num | Count of reads mapped to the segment in the normal sample |
| tumor_reads_num | Count of reads mapped to the segment in the normal sample |
| tumor_reads_num | Count of reads mapped to the segment in the tumor sample |
| LOH_frec | Fraction of LOH sites in the segment |
| LOH_status | FALSE -> no LOH; TRUE -> significant LOH; UNCERTAIN -> medium level LOH |
| log2_ratio | Log2 ratio between tumor_reads_num and normal_reads_num |

**\*.PyLOH.segments.extended** The extended segments file after run_model. There are two additional columns:
**\*.PyLOH.segments.extended** The extended segments file after run_model. There are one additional columns:

| Column | Definition |
| :--------------- | :-------------------------------------|
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