Multiple BA.2 sublineages circulating in India: proposal for a fast designation of them to track efficiently emerging sublineages there

[FedeGueli]

((Edited 6/7)): I wrote down uncorrectly the S: 248 mutations mentioned below (now corrected) they are S:Y248S and S:Y248N , sorry everyone for this silly mistake. thx @josetteshoenma for spotting it))

Following the ongoing discussion in #773 "BA.2.75" issue
and the need expressed by @karyakarte to have BA.2 sublineages quickly designated to track them efficiently
and the important comment by @silcn:
"Regarding BA.2 lineages in India: Japan just uploaded 42 sequences from travellers from India, sampled from 27 May to 16 June, which might give a more representative sample given the differences in sequencing quantity across India. Here is the lineage breakdown according to Usher:

17 BA.2.38 (of which 1 is #809)
15 BA.2 (of which 8 are #787, 2 have S:L452M but are not BA.2.56, and 1 has S:R346T+S:L452M but is not BA.2.74)
4 BA.2.56
2 BA.2.74
1 BA.2.75
1 miscellaneous BA.1/BA.2 recombinant
1 BA.4
1 BA.5.2

I agree with the comments in that thread that there is a very strong case for designating #787.

Originally posted by @silcn in #773 (comment) "

Here i ask to designate the indian BA.2 sublineages already proposed in:
(Edited now #809 has been designated BA.2.38.1
#809 = BA.2.38 + S:444N + S:247N + S:Y248S)
#746 = BA.2.38+T7153C+S:K147E, S:K444N, S:I692L, S:417T+ORF1b:D51N
#762 = BA.2.10 S: T22N, S:L368I, S:N969R
Edited
#787 = BA.2+S:346T+S:Y248N now designated BA.2.76

Plus i ask to designate the following unproposed ones (see in the complete sheet here):
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Lineages	Query x Growth adv	Week Growth Adv	Query for sequences	Nr of Seqs	country	Issue	designation status	Author	Usher tree
BA.2.38+T7153C+S:444N+ORF1a:N3725S+orf1a:T1543I+C17373T+orf1a:T4355I+S:157S		cluster	https://cov-spectrum.org/explore/World/AllSamples/Past6M/variants?aaMutations=S%3A444N%2CORF1a%3AN3725S%2Corf1a%3AT1543I%2Corf1a%3AT4355I%2CS%3A157S&nucMutations=T7153C%2CC17373T&	15	India		Unproposed	Sakaguchi	https://nextstrain.org/fetch/genome.ucsc.edu/trash/ct/subtreeAuspice1_genome_18b9b_ef0ab0.json?branchLabel=aa%20mutations&c=pango_lineage_usher&label=nuc%20mutations:C4893T,A11439G
BA.2.38+S:417T+C21622T+S:71F, S:478R,	https://cov-spectrum.org/explore/World/AllSamples/Past2M/variants?aaMutations=M%3A3N&nucMutations=12160A&aaMutations1=S%3A417T%2CS%3A71F%2CS%3A478R&analysisMode=CompareToBaseline&	-34%	https://cov-spectrum.org/explore/World/AllSamples/Past6M/variants?aaMutations=S%3A478R%2CS%3A71F&aaMutations1=ORF1a%3A556K%2CN%3AP364L%2CORF1a%3AD930N%2CORF1a%3AP3504L%2CN%3A136&nucMutations1=A11782G%2C12160A&	70	India		Unproposed	Zach	https://nextstrain.org/fetch/genome.ucsc.edu/trash/ct/subtreeAuspice1_genome_5c74_eee6e0.json?branchLabel=aa%20mutations&c=pango_lineage_usher&label=nuc%20mutations:C21622T
BA.2+K3353R+S:452M+0rf10:24L (G29628T)	https://cov-spectrum.org/explore/World/AllSamples/Past3M/variants?aaMutations=M%3A3N&nucMutations=12160A&aaMutations1=S%3A452M&nucMutations1=G29628T&analysisMode=CompareToBaseline&	-38%	https://cov-spectrum.org/explore/World/AllSamples/Past6M/variants?aaMutations=S%3A452M&nucMutations=G29628T&aaMutations1=S%3A452M&nucMutations1=G29628T&	147	India		Unproposed	Fede	https://nextstrain.org/fetch/genome.ucsc.edu/trash/ct/subtreeAuspice1_genome_38a02_f02a90.json?branchLabel=aa%20mutations&c=pango_lineage_usher&label=nuc%20mutations:G29628T
BA.2+29628T + S:452M	https://cov-spectrum.org/explore/India/AllSamples/Past3M/variants?aaMutations=M%3A3N&nucMutations=12160A&aaMutations1=S%3A452M&nucMutations1=29628T&analysisMode=CompareToBaseline&	-52%	https://cov-spectrum.org/explore/World/AllSamples/Past6M/variants?aaMutations=S%3A452M&nucMutations=29628T&	104	India		Unproposed	Fede	https://nextstrain.org/fetch/genome.ucsc.edu/trash/ct/subtreeAuspice1_genome_380f2_f02710.json?branchLabel=aa%20mutations&c=pango_lineage_usher&label=nuc%20mutations:G29628T

[FedeGueli]

One more potentially interesting found by @Sinickle

Lineages	Query x Growth adv	Week Growth Adv	Query for sequences	Nr of Seqs	country	Issue	designation status	Author	Usher tree
BA.2.38 + S:346T+ orf1a:3763FI+C26942T	https://cov-spectrum.org/explore/India/AllSamples/Past2M/variants?aaMutations=M%3A3N&nucMutations=12160A&aaMutations1=S%3A417T%2CS%3A346T&nucMutations1=26942T&analysisMode=CompareToBaseline&	-45%	https://cov-spectrum.org/explore/World/AllSamples/Past6M/variants?aaMutations=S%3A346T%2CS%3A417T%2COrf1a%3A3763F&nucMutations=26942T&	30	India		Unproposed	Nick	https://nextstrain.org/fetch/genome.ucsc.edu/trash/ct/subtreeAuspice2_genome_bfe4_fa21b0.json?branchLabel=aa%20mutations&c=pango_lineage_usher&label=nuc%20mutations:G8653C,C26942T

https://docs.google.com/spreadsheets/d/1zKF3PKaosF3OCcW54gWkyV7Spz8uWrCsYef9IHbj7FA/edit?usp=drivesdk

it is just 30 sequences but 13 out of 30 have S:483A beyond S:346T.

[FedeGueli]

I have added a new sheet to the first one with prevalences of main indian BA.2 sublineages region by region HERE

It seems that it is a team work for fast BA.2 sublineages in keeping BA.5 at the corner. This could mean they are really trasmissible as BA.5 but also that some growth advantage estimated just on India with CovSpectrum could be artificially high.

@corneliusroemer @thomaspeacock @chrisruis @AngieHinrichs

[FedeGueli]

Another sublineage appears to being growing fast in India it is a branch of the one proposed by @c19850727 in #812
it is defined by:
S:450D + S:Y248S
then
orf1a:2016I +orf1b:1416V
It reached 28 seqs from 6 less than one week ago.
and this sublineage has been detected in Singapore, Australia, Israel one sequence each that gives me the idea of travel related samples
https://nextstrain.org/fetch/genome.ucsc.edu/trash/ct/subtreeAuspice1_genome_42338_46cdd0.json?branchLabel=aa%20mutations&c=country&label=nuc%20mutations:C6312T

[FedeGueli]

Updated list below, cc @chrisruis @corneliusroemer @karyakarte
It remains to designate just the indian sublineage of #812 that shows growth advantage versus BA.5

here:

BA.2.75( S:K147E, S:W152R, S:F157L, S.I210V, S:G257S, S:D339H, S:G446S, S:N460K, S:R493Q	https://cov-spectrum.org/explore/India/AllSamples/Past2M/variants?aaMutations=M%3A3N&nucMutations=12160A&aaMutations1=S%3A339H%2CS%3A460K%2CE%3A11A&analysisMode=CompareToBaseline&	750,00%
BA.2.38.1 (S:K444N + S:S247N + S:Y248S)	https://cov-spectrum.org/explore/India/AllSamples/Past1M/variants?aaMutations=M%3A3N&nucMutations=12160A&aaMutations1=s%3A248s%2Cs%3A247n%2Cs%3A417t%2Cs%3A444n&pangoLineage1=ba.2*&analysisMode=CompareToBaseline&	312%
BA.2+ S:N450D + S:Y248S+orf1a:T2016I +orf1b:1416V+C16887T	https://cov-spectrum.org/explore/India/AllSamples/Past2M/variants?aaMutations=M%3A3N&nucMutations=12160A&aaMutations1=S%3A450D%2CS%3A248S%2Corf1a%3A2016I%2Corf1b%3A1416V&nucMutations1=C16887T&analysisMode=CompareToBaseline&	38%
BA.2.74+(14925T+C538T+S:R346T+S:L452M)	https://cov-spectrum.org/explore/India/AllSamples/Past3M/variants?aaMutations=M%3A3N&nucMutations=12160A&variantQuery1=+S%3A346T+%26+NextcladePangoLineage%3ABA.2*+%26+S%3A452M&analysisMode=CompareToBaseline&	46%
BA.2.76 (S:R346T+S:Y248N)	https://cov-spectrum.org/explore/India/AllSamples/Past3M/variants?aaMutations=M%3A3N&nucMutations=12160A&aaMutations1=S%3A346T%2CS%3AY248N&pangoLineage1=BA.2&analysisMode=CompareToBaseline&	6%

BA.2.75( S:K147E, S:W152R, S:F157L, S.I210V, S:G257S, S:D339H, S:G446S, S:N460K, S:R493Q https://cov-spectrum.org/explore/India/AllSamples/Past2M/variants?aaMutations=M%3A3N&nucMutations=12160A&aaMutations1=S%3A339H%2CS%3A460K%2CE%3A11A&analysisMode=CompareToBaseline& 750,00%
BA.2.38.1 ( S:K444N + S:S247N + S:Y248S ) https://cov-spectrum.org/explore/India/AllSamples/Past1M/variants?aaMutations=M%3A3N&nucMutations=12160A&aaMutations1=s%3A248s%2Cs%3A247n%2Cs%3A417t%2Cs%3A444n&pangoLineage1=ba.2*&analysisMode=CompareToBaseline& 312%
S:N450D + S:Y248S+orf1a:T2016I +orf1b:1416V+C16887T https://cov-spectrum.org/explore/India/AllSamples/Past2M/variants?aaMutations=M%3A3N&nucMutations=12160A&aaMutations1=S%3A450D%2CS%3A248S%2Corf1a%3A2016I%2Corf1b%3A1416V&nucMutations1=C16887T&analysisMode=CompareToBaseline& 38%
BA.2.74+(14925T+C538T+S:R346T+S:L452M) https://cov-spectrum.org/explore/India/AllSamples/Past3M/variants?aaMutations=M%3A3N&nucMutations=12160A&variantQuery1=+S%3A346T+%26+NextcladePangoLineage%3ABA.2*+%26+S%3A452M&analysisMode=CompareToBaseline& 46%
BA.2.76 (S:R346T+S:Y248N) https://cov-spectrum.org/explore/India/AllSamples/Past3M/variants?aaMutations=M%3A3N&nucMutations=12160A&aaMutations1=S%3A346T%2CS%3AY248N&pangoLineage1=BA.2&analysisMode=CompareToBaseline& 6%
https://docs.google.com/spreadsheets/d/1zKF3PKaosF3OCcW54gWkyV7Spz8uWrCsYef9IHbj7FA/edit?usp=drivesdk

[chrisruis]

Thanks everyone for the great work with these

This is what I'm seeing, running through the clades in the order they appear in the comments from @FedeGueli above:
Clade in #809
Is exhibiting signs of consistent growth as a proportion of BA.2.38/BA.2/Omicron sequences in India (covSpectrum as a proportion of BA.2.38 in India). Has been exported multiple times. It's still quite early but I think worth designating - now added as BA.2.38.1 to start on the branch with G22302A (S:S247N) and A22305C (S:Y248S)

Clade in #746
Clade within BA.2.38, doesn't appear to be growing as a proportion of BA.2.38 sequences in India:

Similar picture when moving back in the tree to incorporate deeper branches. Has been identified in multiple regions but without evidence of increasing as a proportion of BA.2.38 in any region from what I can see. So this one probably doesn't warrant a designation at this stage

Clade in #762
All of the current sequences within this clade were collected from Tamil Nadu between 28th May and 3rd June. There's not any more recent sequences from this clade from what I can see, despite 775 sequences from Tamil Nadu collected in June. This could be consistent with a single outbreak, as also mentioned in the #762. So I don't think we want to designate this clade at this stage

BA.2.38+T7153C+S:444N+ORF1a:N3725S+orf1a:T1543I+C17373T+orf1a:T4355I+S:157S clade
May have just started to increase as a proportion of BA.2.38 in India but jumps up and down so still very early - let's monitor this one and see what it looks like in the coming days

BA.2.38+S:417T+C21622T+S:71F+S:478R clade
Not currently evidence of increasing as a proportion of BA.2.38/BA.2/Omicron sequences in India:

Has reached reasonable frequency within some regions at some points but without a clear pattern of increasing. So this one probably doesn't warrant a designation at this stage

BA.2+K3353R+S:452M+0rf10:24L (G29628T) clade
Has stayed as quite a low proportion of BA.2 in India without evidence of increasing through time. However, looking at this in the UShER tree, this clade shows some geographical focus in India so we can designate based on that. We've added this as BA.2.78 to start on the branch with G29628T (Orf10:R24L). This mutation is quite near the end of the genome but almost all sequences also have C22916A (S:L452M)

BA.2+29628T + S:452M clade
Same as BA.2+K3353R+S:452M+0rf10:24L (G29628T) clade above (now BA.2.78)?

BA.2.38 + S:346T+ orf1a:3763FI+C26942T clade
Not seeing evidence of this one increasing as a proportion of BA.2.38/BA.2/Omicron in India:

So don't think this one warrants a designation at this stage

Subclade within the clade from #812
These sequences exhibit a clear epidemiological event through introduction(s) into India. We've therefore added this as BA.2.79.1 to start on the branch with C6312T (Orf1a:T2016I)

Happy to have another look if anything changes with these. Thanks again

@FedeGueli It might be easiest to close this issue and open a new issue for the BA.2.38+T7153C+S:444N+ORF1a:N3725S+orf1a:T1543I+C17373T+orf1a:T4355I+S:157S clade as this issue has a lot of information in it now

[FedeGueli]

Thank you very much @chrisruis for your very accurate work! I agree with everything stated by you above so:

1. i will open up an issue for the BA.2.38+(XXX)+S:157S one and i'll keep monitored
2. i will keep updated the New BA.2.38 sublineage with S:444N, S:147E, S:692L (350 seqs as of 2022-08-10, mostly India) #746 to see if the picture will become clearer (i suspect that it has reached a significant prevalence somewhere in India, but still probably without a strong growth advantage vs BA.2.38 baseline.
3. I'll keep monitored the S:478R and if it will reach a consistent count of sequences i'll propose it.
4. I'll keep an eye on the tree of the undesignated lineage with S:346T, as we have seen in BA.2.74 and BA.2.76 , one additional mutation could potentially boost its trasmissibility.

Thank you again.

[chrisruis]

Thanks @FedeGueli Sounds good

[FedeGueli]

@chrisruis i ushered the sublineage mentioned above with S:478R ( to name it quickly) it reached 108 Sequences and
@c19850727 spotted a well clustered sublineage of it carrying S:1264L that reached 16 sequences with three exportations one to Japan and one each to Canada and US.

https://nextstrain.org/fetch/genome.ucsc.edu/trash/ct/subtreeAuspice1_genome_242d8_dfc7e0.json?branchLabel=aa%20mutations&c=country&label=nuc%20mutations:C21622T

But what push me to re-open this issue and to designate the BA.2.38 (S:417T) sublineage with C21622T, S:69/70Del, S:S71F, S:T478R is that in the branch with S:1264L two sequences have popped up with S:452Q and S:446S beyond ORF1a:F1214I and nuc: C18744T

cc @AngieHinrichs @InfrPopGen @corneliusroemer @thomaspeacock

[FedeGueli]

Probably better to reopen in a new issue.

[silcn]

38 more Japanese sequences from travellers from India uploaded in the last couple of days. Collection dates 17 June to 6 July. As before, possibly a more representative sample than Indian sequencing provides. Lineage breakdown is as follows:

3 BA.2 (none from proposed lineages)
1 BA.2.3.13 (clusters with sequences from Japan, so probably local transmission)
1 BA.2.12.1
8 BA.2.38 (of which 1 is #746, and 1 has S:K444N plus a reversion of the defining S:417T back to N)
1 BA.2.38.1
4 BA.2.74
2 BA.2.75
8 BA.2.76
8 BA.5.2
1 BA.5.2.1
1 BF.3

[FedeGueli]

Hi @chrisruis (and cc @corneliusroemer @AngieHinrichs @InfrPopGen ) i URGENTLY reopen this issue due to substantial changes in comparison to earlier in July:
It is quite clear that four of the BA.2.38 sublineages described here are slight beyond BA.2.75 transmissibility, and some of their sublineages appear as transmissible as BA.2.75, and the sequence count is now consistent with very widely spread lineages in India with significant international exportation

One of them is BA.2.38.1 already designated
the other three are:

BA.2.38+S:417T+C21622T+S:69/70del, S:S71F, S:T478R proposed in #840
it counts now 180 sequences showing a 25% of growth advantage versus BA.5 in India
but more interesting it has a sublineage defined by S:1264L that counts 48 sequences as today and has a 25% growth advantage versus BA.2.75, even if CIs are wide (-23/+74%) we have to monitor this urgently :

https://cov-spectrum.org/explore/India/AllSamples/Past2M/variants?variantQuery=NextCladePangoLineage%3ABA.2.75*&aaMutations1=S%3A417T%2CS%3A71F%2CS%3A478R%2CS%3A1264L&analysisMode=CompareToBaseline&
More interestingly this sub-sublineage gained then S:452Q (10Seqs) and then S:446S (9/10 sequences)

https://nextstrain.org/fetch/genome.ucsc.edu/trash/ct/subtreeAuspice1_genome_37be8_b9f270.json?branchLabel=aa%20mutations&c=pango_lineage_usher&label=nuc%20mutations:G25352T

I suggest a fast designation of this one and its main sublineage with S:1264L

2. EDITED: Now this has been DESIGNATED BA.2.38.2
   BA.2.38+T7153C+S:444N+ORF1a:N3725S+orf1a:T1543I+C17373T+orf1a:T4355I+S:F157S proposed in BA.2.38 sublineage defined by S:K444N, Orf1a:T1543I, Orf1a:N3725S, Orf1a:T4355I and S:F157S circulating in India (142 sequences) #828
   This sublineage now counts 142 sequences and shows a weekly growth advantage vs BA.5 baseline in India of 14%
   but more interestingly has just a -11% of disadvantage versus BA.2.75 in India ( comparable to the BA.4 vs BA.5 disadvantage):
   
   https://cov-spectrum.org/explore/India/AllSamples/Past2M/variants?variantQuery=NextCladePangoLineage%3ABA.2.75*&aaMutations1=ORF1a%3AN3725S%2Corf1a%3AT1543I%2CS%3A157S&nucMutations1=T7153C%2CC17373T%2C25416T&analysisMode=CompareToBaseline&
   Interestingly a sublineage of this one gained Orf1a:A2529V the def mutation of highly efficient AY.4 Delta sublineage:
   
   https://nextstrain.org/fetch/genome.ucsc.edu/trash/ct/subtreeAuspice1_genome_3844a_b9f920.json?branchLabel=aa%20mutations&c=pango_lineage_usher&label=nuc%20mutations:C2623T

BA.2.38+T7153C+S:K147E, S:K444N, S:I692L, S:K417T+ORF1b:D51N proposed in #746
Now this counts 194 sequences and has a 10% of growth advantage versus BA.5 in India although its disadvantage versus BA.2.75 is clearly around 40%:

https://cov-spectrum.org/explore/India/AllSamples/Past2M/variants?variantQuery=NextCladePangoLineage%3ABA.2.75*&aaMutations1=S%3AK147E%2CS%3AI692L&analysisMode=CompareToBaseline&
International spread is in 4 different continents since before sequence of this was sampled in India suggesting maybe high prevalence in some downsampled state of India

https://nextstrain.org/fetch/genome.ucsc.edu/trash/ct/subtreeAuspice1_genome_37c2a_b9f3a0.json?branchLabel=aa%20mutations&c=country&label=nuc%20mutations:C6445T
Even if actually has not the characteristics to compete with BA.2.75 i think a designation will help everyone to track it

Daily updated tracker (Now upgraded with growth advantage estimated vs BA.2.75) EDIT

:https://docs.google.com/spreadsheets/d/1zKF3PKaosF3OCcW54gWkyV7Spz8uWrCsYef9IHbj7FA/edit#gid=0

[FedeGueli]

I have added #877 by @ryhisner @Sinickle
to the list of monitored lineages:
https://docs.google.com/spreadsheets/d/1zKF3PKaosF3OCcW54gWkyV7Spz8uWrCsYef9IHbj7FA/edit?usp=drivesdk

Very early to say anything but still something to monitor closely cc @karyakarte

[silcn]

Just posting here to mention that two more of the Indian BA.2.10 that I mentioned in #298 have turned up, and this feels like a better place to talk about it. All three (EPI_ISL_13929780, EPI_ISL_14056750, EPI_ISL_14056762) are from Maharashtra. Spike mutations W64R, 141-144del, 242-243del, G446S, F486P, R493Q, S494P, P1143L, maybe a reversion of S371F, and possibly more in S2 where all the sequences have lots of NNNs.

[FedeGueli]

Thx so much @silcn also @zach-hensel spotted these 3 ones (he is monitoring 486P) i add to the list mentioned above to monitor this possible new sublineage.

it should have ORF7a:A105V too.

Potential query : https://cov-spectrum.org/explore/World/AllSamples/Past6M/variants?aaMutations=S%3AW64R%2CS%3AG446S%2CS%3AF486P%2CS%3AS494P%2CS%3AP1143L&

[silcn]

Another one for the watchlist: EPI_ISL_14166909, EPI_ISL_14167044 from West Bengal
BA.2.10.1 with additional S:V83A, H146Q, Q183E, V213E, G339H, R346T, L368I, V445P, G446S, V483A, F490V, S1003I

[FedeGueli]

Thanks @silcn def something to watch closely.
Added to the list (i will fulfill with covspectrum query later)

[FedeGueli]

I have added to the indian sublineages sheet ( https://docs.google.com/spreadsheets/d/1zKF3PKaosF3OCcW54gWkyV7Spz8uWrCsYef9IHbj7FA/edit?pli=1#gid=1869004490)

a new sheet dedicated to Clusters with multiple spike mutations mainly found and tracked by @silcn @Sinickle @ryhisner @zach-hensel @c19850727 @bitbyte2015 and others:

This new sheet reports just numbers of sequences and numbers of spike mutations to keep it clean and readble at first glance. It will be ordered by number of sequences from highest to lowest.

So the clusters we are monitoring actually are:

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Lineages

S:Y248S +orf1a:271S+17004T
BA.2.74 + S:K462N
BA.2 with S:64R, S:75V, S:138-144del (in 4/4 seqs), S:243del, S:493Q, S:572N, S:843G, S:1113R
BA.2.10+W64R, 141-144del, 243-244del, G446S, F486P, R493Q, S494P, P1143L,
ba.2.38 + C18804T + s:417t, s:450d
BA.2 +S:262S + S:348P + S:765L+ S:936Y (+ many others)
ba.2.38 + C4898T, A6293G, A14205C, T15843C + s:417t, s:450d, Orf1a:I2010V, Orf1a:H1545Y
BA.2.38 + S:1084Y, S:452Q, S:417T, S:R346T, orf1a:V3763F
BA.2.10 plus spike P9L, R21I, G446D, N460K and R493Q
BA.2.78 S:452M+A10323G+S:444R
BA.2+C11173T + Orf3a:101F, S:I68K, Orf7b:F16C
BA.2.10.1 with additional S:V83A, H146Q, Q183E, V213E, G339H, R346T, L368I, V445P, G446S, V483A, F490V, S1003I
S:W64L, S:F157S, S:R158S, S:N440R, S:T478R, S:D568N
BA.2.76+S:356T

cc @chrisruis @InfrPopGen @corneliusroemer @AngieHinrichs

[silcn]

@FedeGueli I think "BA.2 +S:262S + S:348P + S:765L+ S:936Y (+ many others)" is the one I proposed way back in #770 which ended up not going anywhere.

[c19850727]

@silcn 7 more sequences of BA.2.10.1 just uploaded, from India-WB, all with spike V83A, H146Q, Q183E, V213E, G339H, R346T, L368I, V445P, G446S, V483A, F490V, S1003I like you mentioned, and also an additional spike G798D.

They have this (convergent?) ORF1b:G662S as well.

[FedeGueli]

Thx @c19850727 i think it is worth proposing it on its own
due to number of spike mutations, 15

[FedeGueli]

I would say that after last designations (and after the last big ba.2.38 sublineage 's issue being reopened ) this issue will be closed as completed . Thank you to the pango team for taking time to look at this deeply and to indian scientists for their super work in the labs to sequence more and more samples in thess two past months.