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Fix Stereochemistry of Phytanic Acid Oxidation #805
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…med to (3S)-phytanic acid
…placed MAM00564x with MAM20083x in MAR03488
…amed them to (3S)-pristanic acid in earlier commit)
…of (2R)-pristanic acid
JHL-452b
reviewed
Apr 7, 2024
feiranl
approved these changes
Apr 24, 2024
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LGTM!
3 tasks
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Main improvements in this PR:
As proposed in #773:
MAM02746e
,MAM02746c
andMAM02746x
to "(3R)-phytanic acid"MAM03884e
,MAM03884c
andMAM03884x
and renamed them to "(3S)-phytanic acid"MAR00659
andMAR01617
(exchange and [e] <-> [c] transport reactions forMAM03884
)MAM02747c
andMAM02747x
to "(3R)-phytanoyl-CoA"MAM02746c
withMAM03884c
inMAR03388
MAR03481
to beMAM02747c + MAM01371c + 2 MAM02040c -> MAM02746x + MAM01597c + MAM02039c + MAM01285c + MAM02751c
, GPR:ENSG00000117528
, references:PMID:24333844;PMID:33500543
MAR06779
to beMAM03362c + MAM01371c + 2 MAM02040c -> MAM03384x + MAM01597c + MAM02039c + MAM01285c + MAM02751c
, GPR:ENSG00000117528
, references:PMID:24333844;PMID:33500543
MAM02746x
withMAM03884x
inMAR03389
MAM00655x
to "(3R)-2-hydroxyphytanoyl-CoA"MAM20083x
to represent peroxisomal (2R)-pristanalMAM00564x
) withMAM20083x
inMAR03486
MAM02766e
,MAM02766c
, andMAM02766x
to "(2S)-pristanic acid"MAR03488
andMAM00077x
MAM00564x
withMAM20083x
inMAR03488
MAM02766x
withMAM00077x
inMAR03493
MAM00077c
andMAM00077e
to represent cytosolic and extracellular (2R)-pristanic acidMAM02766c
withMAM00077c
inMAR03390
MAR20179
to represent ATP-dependent export of (2R)-pristanic acid from the cytosol to the extracellular environmentMAR20180
to represent exchange of (2R)-pristanic acidWhile I was creating
MAM00077c
andMAM00077e
, I noticed that theMAM02766
metabolites were associated with bothMNXM3342
andMNXM7698
inmetabolites.tsv
, butMNXM7698
has apparently been deprecated in favor ofMNXM3422
, so I edited those rows so that they're only associated withMNXM3342
.I hereby confirm that I have:
develop
as a target branch