-
Notifications
You must be signed in to change notification settings - Fork 44
New issue
Have a question about this project? Sign up for a free GitHub account to open an issue and contact its maintainers and the community.
By clicking “Sign up for GitHub”, you agree to our terms of service and privacy statement. We’ll occasionally send you account related emails.
Already on GitHub? Sign in to your account
Fix/hexanoate #717
Fix/hexanoate #717
Conversation
looks nice - please also merge annotation MAM03684 into MAM02120, such as the BiGG id |
Good spot - added the BiGG id to MAM02120. This was the only annotation missing (MAM02120 was way more complete than MAM03684. |
There was a problem hiding this comment.
Choose a reason for hiding this comment
The reason will be displayed to describe this comment to others. Learn more.
good work
if there is any evidence supporting an irreversible MAR10377? |
thanks for the clarification - may the GPR be updated with any ACOTs (#689), such as ACOT4 or ACOT6? |
For the peroxisomal reaction MAR10377, the best candidate is ACOT8 (ENSG00000101473), as ACOT4 and ACOT6 are known to be rather specific to certain acyl-CoAs. Alongside, mitochondrial reaction MAR10374 was also missing a GPR, I suggest ACOT9 (ENSG00000123130) since mitochondrial ACOTs with known specificity (ACOT2, ACOT7, and THEM5) are specific to very long-chain FAs. |
makes sense - please go ahead to implementation |
Main improvements in this PR:
This PR addresses #716 by removing the hexanoate MAM03684c species, and swapping hexanoic acid MAM02120c where applicable.
Changes done:
I hereby confirm that I have:
develop
as a target branch