Skip to content
New issue

Have a question about this project? Sign up for a free GitHub account to open an issue and contact its maintainers and the community.

By clicking “Sign up for GitHub”, you agree to our terms of service and privacy statement. We’ll occasionally send you account related emails.

Already on GitHub? Sign in to your account

Follow-up manuscript analyses #47

Merged
merged 29 commits into from
Dec 14, 2021
Merged

Follow-up manuscript analyses #47

merged 29 commits into from
Dec 14, 2021

Conversation

dominiquesydow
Copy link
Contributor

@dominiquesydow dominiquesydow commented Dec 11, 2021

Description

Add a few smaller analyses to investigate some more follow-up questions!

Todos

  • 005/009: GAK shows up only on lower ranks for EGFR; where does EGFR go ranked by GAK similarities?
    • Answer: While GAK is on rank 44/50 for EGFR, EGFR is on rank 25/50 for GAK (50 = number of kinases for which we have KiSSim data and Karaman-Davis profiling data for Erlobtinib)
  • 006/015: If we restrict the KiSSim fingerprint only to Erlotinib-interacting residues, how does KiSSim perform then?
    • Answer: Improves performance for some ligands indeed (e.g. Erlotinib-based evaluation)

Questions

None.

Status

  • Ready to go

@dominiquesydow dominiquesydow self-assigned this Dec 11, 2021
@review-notebook-app
Copy link

Check out this pull request on  ReviewNB

See visual diffs & provide feedback on Jupyter Notebooks.


Powered by ReviewNB

@dominiquesydow dominiquesydow changed the title Add notebook on KiSSim ranks from EGFR's and GAK's perspective Follow-up manuscript analyses Dec 11, 2021
@dominiquesydow dominiquesydow merged commit cf8f1b4 into master Dec 14, 2021
@dominiquesydow dominiquesydow deleted the co-author-review branch December 14, 2021 14:44
Sign up for free to join this conversation on GitHub. Already have an account? Sign in to comment
Labels
None yet
Projects
None yet
Development

Successfully merging this pull request may close these issues.

1 participant