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docs: adding "Building ClinVar Database"
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holtgrewe committed Mar 29, 2023
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Expand Up @@ -138,3 +138,15 @@ $ mehari db create txs \
```

You will have to build the transcript database for each genome release that you want and manually specify the release to `--genome-release`.

## Building ClinVar Database

This assumes that you have converted a recent ClinVar XML file to TSV using [clinvar-tsv](https://github.com/bihealth/clinvar-tsv).

```
$ mehari db create seqvar-clinvar \
--path-output-db ~/Data/mehari/db/seqvars/grch37/clinvar \
--path-clinvar-tsv path/to/clinvar_seqvars.b37.tsv.gz
```

You can specify an optional `--genome-release grch37` argument that will be used to check the ClinVar database to be compatible with your data.

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