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Added many false reversions that were causing trouble in XBB, as well…
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… as a few for BQ.1, BQ.1.1, XBB.1(+27915) and XBB.1.5.
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AngieHinrichs committed Feb 26, 2023
1 parent ca64aee commit ac5d7c6
Showing 1 changed file with 40 additions and 1 deletion.
41 changes: 40 additions & 1 deletion src/hg/utils/otto/sarscov2phylo/branchSpecificMask.yml
Original file line number Diff line number Diff line change
Expand Up @@ -33,7 +33,7 @@ BA.1:
[ 21988, 21995 ],
[ 22194, 22217 ], # deletion 22194-22196, insertion after 22204, big mess after that
[ 28362, 28370 ] ]
sites: [ 22813, 22898, 22882, 23854 ]
sites: [ 203, 22813, 22898, 22882, 23854 ]

BA.1.1:
# On the BA.1 branch, so it inherits BA.1 masking.
Expand Down Expand Up @@ -105,3 +105,42 @@ BA.5:
A22992G, A22995C, C23013A, G23018T, G23055A, T23063A, C23075T, G23403A,
T23525C, G23599T, A23604C, T25000C, A26529G, G26577C, A26709G, T27807C,
T27889C, T28271A, C29510A ]

BQ.1:
# Inherits from BA.5
# Mask some suspicious run-of-nearby-site mutations that cause a mini-BQ.1 branch and
# caused trouble when minimizing the tree for pango-designation v1.18.1 pangolin-data release.
representative: England/PHEP-YYGYEQS/2022
sites: [ 114, 117, 244, 256, 258, 261, 264 ]

BQ.1.1:
# Inherits from BQ.1
representative: England/DHSC-CYF1KSU/2022
reversions: [ C22893A, A22942T ]

XBB:
# Inherits from BA.2
# Lots of false reversions; I would also mask G405A except that would be wrong for XBN.
representative: England/PHEC-YY8GAXZ/2022
reversions: [ T2790C, T3037C, A4184G, T4321C, T9344C, G9424A, T10198C, C17859T, G19326A,
T21618C, C21810T, A22000C, G22109C, C22577G, A22578G, C22599G, A22664C, C22679T,
T22686C, G22688A, T22813G, C22895G, C22896T, A22898G, G22942T, A22992G, A22995C,
C23013A, C23019T, C23031T, T24424A, A24469T, T25000C, T26060C, G26577C, A26709G,
T26858C, T27807C ]
XBB.1:
# Inherits from XBB
# Here I'm going a bit past the technical start of XBB.1, to include G27915T to be more sure
# that it's XBB.1 before we mask out the defining mutation of XBB.1
representative: England/LSPA-32578111/2022
reversions: [ T22317G ]

XBB.1.5:
# Inherits from XBB.1
# Don't believe reversions on 27915 once we're as far as XBB.1.*
representative: England/BRBR-326C0A5A/2023
reversions: [ T27915G ]

XBC:
# Inherits nothing! Should find out its deletions.
representative: Philippines/PH-VUI-142736/2022
reversions: [ G5584A, T13019C, T25000C, T28271A ]

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