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Add info about quantitative T2* mapping (closes ME-ICA#464).
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tsalo committed Feb 18, 2020
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23 changes: 21 additions & 2 deletions docs/acquisition.rst
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Expand Up @@ -40,9 +40,28 @@ of the current ATSM (i.e. prototypes).

.. _GE Collaboration Portal: https://collaborate.mr.gehealthcare.com

Other available multi-echo MRI sequences
----------------------------------------

In addition to ME-fMRI, many other MR sequences benefit from acquiring multiple
echoes, including T1-weighted imaging (MEMPRAGE) and susceptibility weighted imaging.
While most of these kinds of sequences fall outside the purview of this documentation,
we do want to document sequences for quantitative T2* mapping.
Estimation of T2* and S0 from ME-fMRI data is inherently noisy, given the
relatively low spatial resolution of EPI data and the limited number of echoes
that can be acquired while maintaining reasonable temporal resolution.
As such, ``tedana`` allows users to provide a T2* map as input to the workflow,
which means that it may be beneficial to acquire a quantitative T2* map if you
are also acquiring ME-fMRI data.

Quantitative T2* mapping can be done with a multi-echo GRE sequence, such as a
multi-echo FLASH stock sequence, with a large number of echoes (e.g., 12).
When acquiring such a scan, it is best to reconstruct both magnitude and phase data.


Acquisition parameter recommendations
-------------------------------------
There is no empirically tested best parameter set for multi-echo acquisition.
There is no empirically tested best parameter set for multi-echo fMRI acquisition.
The guidelines for optimizing parameters are similar to single-echo fMRI.
For multi-echo fMRI, the same factors that may guide priorities for single echo
fMRI sequences are also relevant.
Expand Down Expand Up @@ -88,7 +107,7 @@ and guidelines are discussed in the `appendix`_ of Dipasquale et al, 2017.
ME-fMRI parameters and publications
-----------------------------------

The following page highlights a selection of parameters collected from published papers that have
The following section highlights a selection of parameters collected from published papers that have
used multi-echo fMRI.
The subsequent spreadsheet is an on-going effort to track all of these publication.
This is a volunteer-led effort so, if you know of a excluded publication, whether or not it is yours,
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7 changes: 6 additions & 1 deletion docs/resources.rst
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Expand Up @@ -59,7 +59,7 @@ Other software that uses multi-echo fMRI

``tedana`` represents only one approach to processing multi-echo data.
Currently there are a number of methods that can take advantage of or use the
information contain in multi-echo data.
information contained in multi-echo data.
These include:

* | `3dMEPFM`_: A multi-echo implementation of 'paradigm free mapping', that is
Expand All @@ -77,12 +77,17 @@ These include:
* | `Dual Echo Denoising`_: If the first echo can be collected early enough,
| there are currently methods that take advantage of the very limited BOLD
| weighting at these early echo times.
* | `qMRLab`_: This is a MATLAB software package for quantitative magnetic
| resonance imaging. While it does not support ME-fMRI, it does include methods
| for estimating T2*/S0 from high-resolution, complex-valued multi-echo GRE
| data with correction for background field gradients.
.. _3dMEPFM: https://afni.nimh.nih.gov/pub/dist/doc/program_help/3dMEPFM.html
.. _following paper: https://www.sciencedirect.com/science/article/pii/S105381191930669X
.. _Bayesian approach to denoising: https://ww5.aievolution.com/hbm1901/index.cfm?do=abs.viewAbs&abs=5026
.. _Multi-echo Group ICA: https://ww5.aievolution.com/hbm1901/index.cfm?do=abs.viewAbs&abs=1286
.. _Dual Echo Denoising: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3518782/
.. _qMRLab: https://github.com/qMRLab/qMRLab

Datasets
--------
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