New EG.5.1.1 sublineage with S:L455F ( 15 sequences Liaoning, Guangdong, Shanghai, Yunnan,South Korea,Japan, Singapore)

[FedeGueli]

@BorisUitham solicited me to monitor multiple emergences of S:L455F on EG.5.1.1 backbone
so i did, findiing mutliple singlets traceable with the following query (maybe)

1. C17802T,C6781T, G22927C
2. G22899T, G23624T,C8326T, G22927C
3. T6673C, A7150C, G19962A
   which i will monitor privately

but one is already two sequences from two different regions so it si worth proposing it immediately:

Gisaid query: , G22927T,C5031T
EG.5.1.1 >> C6541T > orf1a:T1589I (C5031T) > orf1a:T4249I C13011T, S:L455F (G22927T)

Sequences:
EPI_ISL_18034950, (Guangdong)
EPI_ISL_18049761 (Liaoning)

Tree:

https://nextstrain.org/fetch/genome.ucsc.edu/trash/ct/subtreeAuspice1_genome_90e8_a33420.json?c=gt-S_455&label=id:node_6755361

[xz-keg]

8 seqs now， 6 are without C13011T and only have C5031T

[FedeGueli]

C13011T, G22927T,C5031T

Thank you i am re-tuning the query.

HEre it is : G22927T,C5031T

[FedeGueli]

3 more sequences of this one all from Shanghai all very recent

[xz-keg]

+2 South Korea

[FedeGueli]

+2 Japan,Singapore (local case)

[FedeGueli]

@ryhisner @HynnSpylor @avichzl2 @NkRMnZr i think all these EG.5.1* plus 455 should be transferred to Pango at 10seqs they clearly go and there is a need to distinguish them ( a taxonomy need more than epi but still, it was as 346 460+444 popped up even if the real competitive at the end have been 3-4-5 lineages i think is right to describe the tree. assuming Pirola not doing a BA.1 to everyone)

[xz-keg]

I think all of these>10 branches(there are at least 5 of them now) shall be designated. Currently the only designated is HK.3, however non-HK.3 flips are nothing worse than HK.3 and all of them are growing fast.

[FedeGueli]

Thx @aviczhl2 i will propose it indeed.