XBB.3.4 with S:K182E and S:F486P (17 seqs, 9 countries)

[NkRMnZr]

Defining Mutations: XBB.3.4 > C23191T > A22106G(S:K182E) > T23018C(S:F486P over existing F486S/T23019C)
Query: A22106G, T23018C, C3961T
Earliest seq: 2023-02-19 (EPI_ISL_17391197, Maharashtra, India)
Latest seq: 2023-06-04 (EPI_ISL_17816358, Thailand)
Sampled Countries: Australia (4), Russia (4), South Korea (3), Denmark (1), France (1), India (1), Israel (1), Thailand (1), UK (1, England)

Genomes:

EPI_ISL_17241536, EPI_ISL_17246129, EPI_ISL_17283807, EPI_ISL_17293925, EPI_ISL_17374099, EPI_ISL_17391197, EPI_ISL_17480102, EPI_ISL_17481959, EPI_ISL_17566466, EPI_ISL_17664955, EPI_ISL_17665585, EPI_ISL_17683505, EPI_ISL_17788119, EPI_ISL_17816358, EPI_ISL_17818280, EPI_ISL_17823705, EPI_ISL_17823807

UShER:
https://nextstrain.org/fetch/genome.ucsc.edu/trash/ct/subtreeAuspice1_genome_2e205_e713f0.json?f_userOrOld=uploaded%20sample&showBranchLabels=all

view from XBB's ORF1a:G82D polytomy

diversity from XBB.3.4

Trivia:

• There are several attempts to get S:F486P, the main proposal is the largest cluster from this lineage, the other branches are filtered from above query.
• One under C12439T sub-branch, Shanghai/SCDC-XG04-3194/2023|EPI_ISL_17619154|2023-04-21, query: A14388G, G24095T, T23018C
• Another under S:R273K(G22380A) branch, Sweden/D-6335667176/2023|EPI_ISL_17884696|2023-06-10, query: G22380A, T23018C, C23444A
• Definitely not a fast one, but samples are collected from multiple countries around the world.

[NkRMnZr]

slow, tracking it privately