FY.6 sublineage got S:R408N in France, Spain (50 seqs)

[FedeGueli]

I spotted a sublineage of FY.6 that has acquired an AA substitution at one of defining mutations of BA.2 S:R>S408N

Tree:


https://nextstrain.org/fetch/genome.ucsc.edu/trash/ct/subtreeAuspice1_genome_2a8f_3a240.json?c=gt-S_408&label=id:node_6709465

Defining mutations:
FY.6>> C13620T > A23989C > S:S408N (G22785A )

Gisaid query: C13620T , A23989C,G22785A

Samples:
EPI_ISL_17541214, EPI_ISL_17559425, EPI_ISL_17652568,
EPI_ISL_17679326, EPI_ISL_17679477, EPI_ISL_17679678,
EPI_ISL_17731319, EPI_ISL_17761393, EPI_ISL_17804764,
EPI_ISL_17817736, EPI_ISL_17937833, EPI_ISL_17948484,
EPI_ISL_17949078, EPI_ISL_17949110

FIrst: hCoV-19/Spain/AN-PMC-34534/2023 | Original | EPI_ISL_17541214 | 2023-04-12

[HynnSpylor]

S:R408N is abnormally "popular" in XBB.1.22.1*, as it can be also found in FY.1.1 sublineage and my proposal in pango #2053
https://github.com/cov-lineages/pango-designation/issues/2053

[FedeGueli]

Yeah XBB.1.22.1 seems able to gain more different mutations or before the other lineages.

[FedeGueli]

one more from Canada

[FedeGueli]

Closing for now

[FedeGueli]

Thx @NkRMnZr

[FedeGueli]

It still cant compete but it has some sort of circulation in France.
https://cov-spectrum.org/explore/World/AllSamples/Past3M/variants?nextcladePangoLineage=HK.3*&nucMutations1=C13620T%2CA23989C%2CG22785A&analysisMode=CompareToBaseline&

[FedeGueli]

It reached Australia today. I m closing it. pinging @corneliusroemer about 408 mutations in the case could be useful to designate one of them.

[FedeGueli]

https://nextstrain.org/fetch/genome-test.gi.ucsc.edu/trash/ct/subtreeAuspice1_genome_test_5a48c_355390.json?c=userOrOld&label=id:node_3225385
Some circulation of this in France.