FY.5 (XBB.1.22.1.5) sublineage with S:L176F and Orf9b:S6N (71)

[HynnSpylor]

Defining mutations: FY.5>A6019G>C22088T(S:L176F), G28300A
GISAID query: G28300A, C22088T, A22161G, C22995G
Earliest seq: 2023-03-25 (Indonesia, EPI_ISL_17696519)
Most recent seq: 2023-06-13 (USA, EPI_ISL_17838373)
Detected Countries: Indonesia (5), USA (3), Australia (2), Singapore (1), South Korea (1)

Usher Tree:

https://nextstrain.org/fetch/genome.ucsc.edu/trash/ct/subtreeAuspice1_genome_c865_b12fa0.json?c=gt-S_176

S:L176F emerged in some B.1.1.7 (Alpha) and B.1.177 branches and still arise in CH.1.1* and BQ* sublineages, and it can slightly enhance the fitness by Bloom and Neher (2023).

https://jbloomlab.github.io/SARS2-mut-fitness/S.html

one single seq from Singapore is interesting with S:L179P and S:K182Q.

Genomes
EPI_ISL_17696519, EPI_ISL_17736313, EPI_ISL_17740666, EPI_ISL_17793439, EPI_ISL_17815049, EPI_ISL_17815873,
EPI_ISL_17832385, EPI_ISL_17833340, EPI_ISL_17833345, EPI_ISL_17835856, EPI_ISL_17838373, EPI_ISL_17854290,

[FedeGueli]

Yeah i m quite sure multiple BA.2 sublineages got it too early in 2022 before being smashed by BA.2.12.1/BA.4&BA.5.
So my idea that is one those mutations slighty useful for transmissibility, not enough to make the dfference. BUt good to track how it goes on XBB backbone. My idea of this proposal page is to trying to understand dynamics and changes in dynamics beyond the pre-designation tracking.

[HynnSpylor]

2 more seqs from Canada and Austria

[HynnSpylor]

4 more seqs from UK, US, Austria and Belgium

[HynnSpylor]

4 more seqs from US, UK, NZ and Austria

[HynnSpylor]

I'll close the issue as @ryhisner has mentioned in main page
cov-lineages/pango-designation#2101

[FedeGueli]

71 now.

[FedeGueli]

Designated FY.5.2 via cov-lineages/pango-designation@a60930a

[NkRMnZr]

G28300A is also ORF9b:S6N

[FedeGueli]

C22088T is also ORF9b:S6N

G28300A is Orf9b:S6N . thank you

[NkRMnZr]

G28300A

aha copy paste error again

[FedeGueli]

G28300A

aha copy paste error again

too mess! the whole thing will drive us mad at the end ;) Are you already in "Car Plate= mutations " phase?