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NJ.1 (S:F59L,R346T,F456L+Orf3a:K16N+S:K478T) with S:N185S (5), and further S:T22N, M153I (3) #2068

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xz-keg opened this issue Sep 20, 2024 · 8 comments

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@xz-keg
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xz-keg commented Sep 20, 2024

Most seqs on this JN.1.11+S:R346T branch are dropouts from KP.2*. However, there seems to be a real branch hiding inside.

JN.1.11+C7979T, A12463G,T21737C,G22599C, T22928C(S:F59L,R346T,F456L)+G25440T(Orf3a:K16N)+C20436T, C21381T,A22995C(S:K478T rev)

All seqs have C7979T,A12463G have G17334T but not C7113T, this means it shall be a descendant directly from JN.1.11. And these two mutations do not appear in other lineages so small chance of recombinant.

And the S:K478T rev sub-branch is particularly interesting as it harbors recent GBW seqs from both China and India as well as USA local seq.

GISAID query: C7979T, A12463G,C20436T
GISAID query for S:N185S sub-branch: A12463G,C20436T,A22116G
GISAID query for S:T22N,M153I further sub-branch: A12463G,C20436T,A22116G,C21627A
No. of seqs: 6(Canada 1 USA 5(1 from China, 2 from India))

First: EPI_ISL_19264665, 2024-7-9,Canada
Latest: EPI_ISL_19427404, 2024-9-9, USA from China

usher
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@xz-keg xz-keg changed the title JN.1.11+S:F59L,R346T,F456L+Orf3a:K16N+S:K478T(rev) JN.1.11+S:F59L,R346T,F456L+Orf3a:K16N+S:K478T(rev)( 6 seqs, 3 countries) Sep 20, 2024
@xz-keg xz-keg changed the title JN.1.11+S:F59L,R346T,F456L+Orf3a:K16N+S:K478T(rev)( 6 seqs, 3 countries) JN.1.11+S:F59L,R346T,F456L+Orf3a:K16N+S:K478T(rev)( 6 seqs, 4 countries) Sep 20, 2024
@FedeGueli
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this is a sublineage of branch 61 of #1089 ! then proposed in Pango cov-lineages/pango-designation#2542 , but better to trrack the 478T sublineage here, not worth reopening the old things. thx for spotting it.

@FedeGueli
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i was tracking this too with C7979T, A12463G,C21381T but your query catches one more.

@xz-keg
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xz-keg commented Oct 9, 2024

No further seqs

@xz-keg xz-keg closed this as completed Oct 9, 2024
@xz-keg
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xz-keg commented Oct 11, 2024

+2 USA-NJ, with additional S:N185S, T22N and M153I

@xz-keg xz-keg reopened this Oct 11, 2024
@xz-keg xz-keg changed the title JN.1.11+S:F59L,R346T,F456L+Orf3a:K16N+S:K478T(rev)( 6 seqs, 4 countries) JN.1.11+S:F59L,R346T,F456L+Orf3a:K16N+S:K478T(rev)( 8 seqs, 4 countries, 4 with S:N185S, 2 with further S:T22N, M153I) Oct 11, 2024
@xz-keg xz-keg removed the recomb? label Oct 11, 2024
@FedeGueli FedeGueli changed the title JN.1.11+S:F59L,R346T,F456L+Orf3a:K16N+S:K478T(rev)( 8 seqs, 4 countries, 4 with S:N185S, 2 with further S:T22N, M153I) JN.1.11+S:F59L,R346T,F456L+Orf3a:K16N+S:K478T(rev)( 9 seqs, 4 places, 4 with S:N185S, 2 with further S:T22N, M153I) Oct 15, 2024
@FedeGueli
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+1 Colorado

@xz-keg
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xz-keg commented Oct 25, 2024

designated NJ.1 via cov-lineages/pango-designation@608685e

@xz-keg xz-keg closed this as completed Oct 25, 2024
@xz-keg xz-keg added this to the NJ.1 milestone Oct 25, 2024
FedeGueli referenced this issue in cov-lineages/pango-designation Oct 25, 2024
@FedeGueli FedeGueli changed the title JN.1.11+S:F59L,R346T,F456L+Orf3a:K16N+S:K478T(rev)( 9 seqs, 4 places, 4 with S:N185S, 2 with further S:T22N, M153I) JN.1.11+S:F59L,R346T,F456L+Orf3a:K16N+S:K478T(rev)( 11 seqs, 4 places, 5 with S:N185S, 3 with further S:T22N, M153I) Oct 27, 2024
@FedeGueli FedeGueli changed the title JN.1.11+S:F59L,R346T,F456L+Orf3a:K16N+S:K478T(rev)( 11 seqs, 4 places, 5 with S:N185S, 3 with further S:T22N, M153I) NJ.1 (S:F59L,R346T,F456L+Orf3a:K16N+S:K478T) with S:N185S 85), and further S:T22N, M153I (3) Oct 27, 2024
@FedeGueli FedeGueli reopened this Oct 27, 2024
@FedeGueli
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Worth tracking its sublineages

@FedeGueli FedeGueli changed the title NJ.1 (S:F59L,R346T,F456L+Orf3a:K16N+S:K478T) with S:N185S 85), and further S:T22N, M153I (3) NJ.1 (S:F59L,R346T,F456L+Orf3a:K16N+S:K478T) with S:N185S (5), and further S:T22N, M153I (3) Oct 27, 2024
@FedeGueli
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no new seqs closing it

@FedeGueli FedeGueli closed this as not planned Won't fix, can't repro, duplicate, stale Nov 10, 2024
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