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LU.2 sub-branch with S:L176F (23, Ecuador,Us) with two sublineages one with S:F186S (11) and the other with S:S60P and S:K182N(now LU.2.1.1) #1751

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FedeGueli opened this issue Jul 18, 2024 · 6 comments
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designated FLiRT FLiRT is an Acronym for S:R346T + S:F456L High local prevalence Lineage that apparently gained high prevalence in one country or region PLPro S:60 S:176 s:182 S:186 S:688

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@FedeGueli
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FedeGueli commented Jul 18, 2024

Credit: spotted by @HynnSpylor
LU.2 reached a sky-high prevalence in Ecuador in late June around 25%.
Looking at its tree i noticed a S:F176F branch that got then splitted in two interesting subbranches: one defined by S:F186S and the other , smaller, with S:S60P and S:K182N.

For now i will propose the broader branch tracking the S:F186S one with an eye on the other branch.

Tree:
Screenshot 2024-07-18 alle 17 47 07
https://nextstrain.org/fetch/genome-test.gi.ucsc.edu/trash/ct/subtreeAuspice4_genome_test_64543_933e10.json?label=id:node_7046252

Defining mutations: LU.2 > T20865C > S:L176F (C22088T) >> S:F186S (T22119C) or >> Orf1a:L204F (C875T), Orf1a:T1854I (C5826T), S:S60P (T21740C), S:K182N (A22108C)
Query for 176F: T20865C ,C22088T, C897A > 14 Samples
Query for 176F+186S: T20865C ,T22119C, C897A > 9 Samples
Query for 60P + 182N: T20865C ,C875T ,C5826T > 5 Samples

@FedeGueli FedeGueli added s:182 PLPro S:186 S:688 S:176 S:60 FLiRT FLiRT is an Acronym for S:R346T + S:F456L High local prevalence Lineage that apparently gained high prevalence in one country or region labels Jul 18, 2024
@HynnSpylor
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Ah I forgot to propose it! the branch with S:S680Y also should be noticed.

@FedeGueli FedeGueli changed the title LU.2 sub-branch with S:L176F (14, Ecuador,Us) with two sublineages one with S:F186S (9) and the other with S:S60P and S:K182N(5) LU.2 sub-branch with S:L176F (15, Ecuador,Us) with two sublineages one with S:F186S (9) and the other with S:S60P and S:K182N(6) Jul 27, 2024
@FedeGueli
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+1 Denmark in the 60P Branch

@FedeGueli FedeGueli changed the title LU.2 sub-branch with S:L176F (15, Ecuador,Us) with two sublineages one with S:F186S (9) and the other with S:S60P and S:K182N(6) LU.2 sub-branch with S:L176F (16, Ecuador,Us) with two sublineages one with S:F186S (9) and the other with S:S60P and S:K182N(7) Aug 3, 2024
@FedeGueli FedeGueli changed the title LU.2 sub-branch with S:L176F (16, Ecuador,Us) with two sublineages one with S:F186S (9) and the other with S:S60P and S:K182N(7) LU.2 sub-branch with S:L176F (16, Ecuador,Us) with two sublineages one with S:F186S (9) and the other with S:S60P and S:K182N(10) Aug 5, 2024
@FedeGueli
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the 60P branch jumped to 10 today with two countries Scotland adn Spain

@FedeGueli FedeGueli changed the title LU.2 sub-branch with S:L176F (16, Ecuador,Us) with two sublineages one with S:F186S (9) and the other with S:S60P and S:K182N(10) LU.2 sub-branch with S:L176F (23, Ecuador,Us) with two sublineages one with S:F186S (9) and the other with S:S60P and S:K182N(14) Aug 10, 2024
@FedeGueli
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23 now all new ones belonging to the 60P 182N sublineage

@xz-keg
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xz-keg commented Aug 15, 2024

Designated LU.2.1 and LU.2.1.1 via cov-lineages/pango-designation@f7249dc

@xz-keg xz-keg closed this as completed Aug 15, 2024
@xz-keg xz-keg added this to the LU.2.1 LU.2.1.1 milestone Aug 15, 2024
NkRMnZr referenced this issue in cov-lineages/pango-designation Aug 15, 2024
@FedeGueli FedeGueli changed the title LU.2 sub-branch with S:L176F (23, Ecuador,Us) with two sublineages one with S:F186S (9) and the other with S:S60P and S:K182N(14) LU.2 sub-branch with S:L176F (23, Ecuador,Us) with two sublineages one with S:F186S (11) and the other with S:S60P and S:K182N(now LU.2.1.1) Aug 29, 2024
@FedeGueli
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Designated LU.2.1 and LU.2.1.1 via cov-lineages/pango-designation@f7249dc

I ve noticed only now that LU.2.1.1 has also T28474C that corresponds to Orf9b:L64P cc @xz-keg

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designated FLiRT FLiRT is an Acronym for S:R346T + S:F456L High local prevalence Lineage that apparently gained high prevalence in one country or region PLPro S:60 S:176 s:182 S:186 S:688
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