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LB.1 + S:S31del with double nuc S:P>L1143F (7) #1557

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FedeGueli opened this issue May 11, 2024 · 3 comments
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LB.1 + S:S31del with double nuc S:P>L1143F (7) #1557

FedeGueli opened this issue May 11, 2024 · 3 comments
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@FedeGueli
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S:P1143L has been removed in some recombinant as XDQ or XDN , instead @aviczhl2 noticed that in some lineages it was further mutated to S:L1143F. This could pint at that mutation to be a slighty deleterious one that BA.2.86 is trying to drop:
Green is 1143L , Orange 1143P (ON BA.2.86 backbone) , Blue is 1143F
Screenshot 2024-05-11 alle 14 08 29

Here i want to propose a small lineage that popped up in the super fast LB.1 lineage:

LB.1 >>S:S31del (del21653-21655 > ORF1b:T1621I (C18329T) >A1096G, T18909C, S:P>L1143F (C24989T)
Query: A1096G, T18909C, C24989T
Samples: 2
EPI_ISL_19101697, EPI_ISL_19130945
Countries : 2 California, Taiwan (imported from unknown country)

Tree:
https://nextstrain.org/fetch/genome-test.gi.ucsc.edu/trash/ct/subtreeAuspice4_genome_test_1e741_ea7b60.json?c=userOrOld&label=id:node_7111785
Screenshot 2024-05-11 alle 14 15 34

@FedeGueli FedeGueli added s:1143 DeFLiRT S:S31/F32-+S:R346T+S:F456L LB.1 labels May 11, 2024
@FedeGueli FedeGueli changed the title LB.1 + S:S31del with double nuc S:P>L1143F LB.1 + S:S31del with double nuc S:P>L1143F (3) May 14, 2024
@FedeGueli
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+1 California, one to watch to me.

@FedeGueli FedeGueli changed the title LB.1 + S:S31del with double nuc S:P>L1143F (3) LB.1 + S:S31del with double nuc S:P>L1143F (4) May 27, 2024
@FedeGueli FedeGueli changed the title LB.1 + S:S31del with double nuc S:P>L1143F (4) LB.1 + S:S31del with double nuc S:P>L1143F (7) Jun 3, 2024
@FedeGueli
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7 with 3 new samples from Thailand

FedeGueli referenced this issue in cov-lineages/pango-designation Jun 4, 2024
@FedeGueli
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Designated LB.1.5 via cov-lineages/pango-designation@edd3d26

@FedeGueli FedeGueli added this to the LB.1.5 milestone Jun 4, 2024
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