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JN.1+ORF1ab:S2242F+S:F456L+S:N960S(18 sequences, mainly in Europe) #1304

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Outpfmance opened this issue Jan 17, 2024 · 15 comments
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JN.1+ORF1ab:S2242F+S:F456L+S:N960S(18 sequences, mainly in Europe) #1304

Outpfmance opened this issue Jan 17, 2024 · 15 comments

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@Outpfmance
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Outpfmance commented Jan 17, 2024

Sub-lineage of:JN.1
Earliest sequence: EPI_ISL_19205731,France,2024-5-28
Latest sequence: EPI_ISL_19229746,USA,2024-6-19
Countries:USA(2),France(2),Ireland(5),Spain(2)
Number of Sequences:12
GISAID query: A24441G,C6990T,T22928C(Edited)
UShER Tree: https://nextstrain.org/fetch/genome.ucsc.edu/trash/ct/singleSubtreeAuspice_genome_1556c_5696d0.json?f_userOrOld=uploaded%20sample&label=id:node_5614567
IMG_0039

@FedeGueli
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thx i ve added a nuc query: C13405T, T17599C, T20185C

@FedeGueli FedeGueli changed the title JN.1+ORF1ab:S2242F+S:P812A+S:N960S—changes on TMPRSS2 cut points and S2 (8 sequences,Canada) JN.1+ORF1ab:S2242F+S:P812A+S:N960S—changes on TMPRSS2 cut points and S2 (9 sequences,Canada) Feb 12, 2024
@FedeGueli FedeGueli added the Small clusters ?? This label identifies lineages with very few sequences,allowing to track them for a couple of weeks label Feb 12, 2024
@FedeGueli
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it looks like a cluster , lets keep it open until the end of the month

@FedeGueli
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Confirmed it was just a cluster closing it for now

@FedeGueli FedeGueli closed this as not planned Won't fix, can't repro, duplicate, stale Mar 3, 2024
@xz-keg
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xz-keg commented Mar 30, 2024

S:P812A may be a cluster, but JN.1+ORF1ab:S2242F+S:N960S seems to grow large. Query A24441G,C6990T finds 146.

image

@xz-keg
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xz-keg commented Jul 3, 2024

There is an S:F456L sub-branch emerging from this.

@FedeGueli
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There is an S:F456L sub-branch emerging from this.

Branch 111 ??

@xz-keg
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xz-keg commented Jul 3, 2024

There is an S:F456L sub-branch emerging from this.

Branch 111 ??

Yeah.

@Outpfmance
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Outpfmance commented Jul 3, 2024

https://nextstrain.org/fetch/genome.ucsc.edu/trash/ct/singleSubtreeAuspice_genome_1556c_5696d0.json?f_userOrOld=uploaded%20sample&label=id:node_5614567
IMG_0039
This is a branch of the F456L, which became popular in Europe at the beginning of June, and a small portion of which also has the R346T.
I think we can reopen the issue. @FedeGueli
Thanks @aviczhl2
GISAID query: A24441G,C6990T,T22928C

@Outpfmance Outpfmance changed the title JN.1+ORF1ab:S2242F+S:P812A+S:N960S—changes on TMPRSS2 cut points and S2 (9 sequences,Canada) JN.1+ORF1ab:S2242F+S:F456L+S:N960S(12 sequences) Jul 3, 2024
@FedeGueli FedeGueli reopened this Jul 3, 2024
@FedeGueli
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Thx @Outpfmance !

@FedeGueli FedeGueli added S:456 s:1143 S:960 and removed Small clusters ?? This label identifies lineages with very few sequences,allowing to track them for a couple of weeks JN.1 labels Jul 3, 2024
@FedeGueli
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Pls update the main text of the proposal @Outpfmance

@Outpfmance Outpfmance changed the title JN.1+ORF1ab:S2242F+S:F456L+S:N960S(12 sequences) JN.1+ORF1ab:S2242F+S:F456L+S:N960S(12 sequences, mainly in Europe) Jul 4, 2024
@Outpfmance
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18 sequences now

@Outpfmance Outpfmance changed the title JN.1+ORF1ab:S2242F+S:F456L+S:N960S(12 sequences, mainly in Europe) JN.1+ORF1ab:S2242F+S:F456L+S:N960S(18 sequences, mainly in Europe) Jul 11, 2024
@FedeGueli FedeGueli added the To be proposed Green light for proposal label Jul 11, 2024
@FedeGueli
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Pls propose it

@FedeGueli
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@Outpfmance pls propose it.

@Outpfmance
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@FedeGueli OK, I have already opened the issue, I don't know why I didn't open it last time.
cov-lineages/pango-designation#2692

@FedeGueli
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Thanks!

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