Skip to content
New issue

Have a question about this project? Sign up for a free GitHub account to open an issue and contact its maintainers and the community.

By clicking “Sign up for GitHub”, you agree to our terms of service and privacy statement. We’ll occasionally send you account related emails.

Already on GitHub? Sign in to your account

HV.1 with S:R452W, ORF1a:T4083M (61 seqs - 7 countries - March 19) #1044

Closed
ryhisner opened this issue Nov 1, 2023 · 12 comments
Closed

HV.1 with S:R452W, ORF1a:T4083M (61 seqs - 7 countries - March 19) #1044

ryhisner opened this issue Nov 1, 2023 · 12 comments
Labels
help wanted Extra attention is needed s:157 S:452 S:456

Comments

@ryhisner
Copy link

ryhisner commented Nov 1, 2023

Making this one very short as I have to run, and I'm not sure if it's significant in any case. If it grows, I'll fill in the details. The 5 sequences come from near-opposite ends of North America. The two other S:R452W sequences that cluster with it on the Usher tree are most likely unrelated.

Query: C5835T, C12513T, A18492G, C22916T

Usher Tree
https://nextstrain.org/fetch/raw.githubusercontent.com/ryhisner/jsons/main/HV.1_R452W.json?c=gt-nuc_12513&label=id:node_11054571

image

Genomes: EPI_ISL_18368684, EPI_ISL_18368708, EPI_ISL_18368715, EPI_ISL_18452865, EPI_ISL_18453010

@FedeGueli FedeGueli changed the title HV.1 with S:R452W, ORF1a:T4083M (5 seq, 2 British Columbia, 3 Florida; Nov 1) HV.1 with S:R452W, ORF1a:T4083M (6 seq, 2 British Columbia, 3 Florida, 1 Greece; Nov 13) Nov 13, 2023
@FedeGueli
Copy link

+1 Greece

@FedeGueli
Copy link

Slow closing it

@FedeGueli FedeGueli closed this as not planned Won't fix, can't repro, duplicate, stale Nov 20, 2023
@FedeGueli FedeGueli added Apparently slow It means that a lineage is accumulating sequences slowly not that it is intrinsically slow. and removed Rapid review needed labels Nov 20, 2023
@xz-keg
Copy link
Contributor

xz-keg commented Dec 29, 2023

18 seqs now

@FedeGueli FedeGueli reopened this Dec 29, 2023
@FedeGueli
Copy link

thx @aviczhl2 reopend it cause still ongoing in December,.

@FedeGueli FedeGueli changed the title HV.1 with S:R452W, ORF1a:T4083M (6 seq, 2 British Columbia, 3 Florida, 1 Greece; Nov 13) HV.1 with S:R452W, ORF1a:T4083M (18 seqs - 5 countries - Dec 29 ) Dec 29, 2023
@xz-keg xz-keg closed this as completed Jan 9, 2024
@xz-keg xz-keg added this to the HV.1.10 milestone Jan 9, 2024
FedeGueli referenced this issue in cov-lineages/pango-designation Jan 9, 2024
@xz-keg
Copy link
Contributor

xz-keg commented Jan 19, 2024

Seems that this is not the real HV.1.10, and S:452W is very very convergent in HV.1

Reopen this.

image

This is a summary of HV.1+S:452W, as can be seem this one is not the HV.1.10. There seems to be at least 30 separate branches of HV.1+S:452W.
https://nextstrain.org/fetch/genome-test.gi.ucsc.edu/trash/ct/singleSubtreeAuspice_genome_test_ff5a_9e2190.json?f_userOrOld=uploaded%20sample&label=id:node_3577511

@ryhisner @FedeGueli @corneliusroemer

@xz-keg xz-keg reopened this Jan 19, 2024
@xz-keg xz-keg removed the designated label Jan 19, 2024
@xz-keg xz-keg removed this from the HV.1.10 milestone Jan 19, 2024
@FedeGueli
Copy link

What a mess there were just two lineages and a few of sequences at the time of designation. I ve checked at that time the sequences used to designate and some of them belonged to this one. cc @corneliusroemer @AngieHinrichs important.

At this point maybe more useful to open a multiple lineages issue. for HV.1 and S:l452W inclusing this one, the HV.1.10 and the NZL proposed one plus other branches with more than 3 seqs

@FedeGueli FedeGueli added help wanted Extra attention is needed and removed Convergent evolution Lineages with convergent mutations Apparently slow It means that a lineage is accumulating sequences slowly not that it is intrinsically slow. labels Jan 19, 2024
@FedeGueli
Copy link

What a mess there were just two lineages and a few of sequences at the time of designation. I ve checked at that time the sequences used to designate and some of them belonged to this one. cc @corneliusroemer @AngieHinrichs important.

At this point maybe more useful to open a multiple lineages issue. for HV.1 and S:l452W inclusing this one, the HV.1.10 and the NZL proposed one plus other branches with more than 3 seqs

scratch my words i was confusing it with 450D , but still @corneliusroemer @AngieHinrichs could you take a look

@FedeGueli
Copy link

Seems that this is not the real HV.1.10, and S:452W is very very convergent in HV.1

Reopen this.

image

This is a summary of HV.1+S:452W, as can be seem this one is not the HV.1.10. There seems to be at least 30 separate branches of HV.1+S:452W. https://nextstrain.org/fetch/genome-test.gi.ucsc.edu/trash/ct/singleSubtreeAuspice_genome_test_ff5a_9e2190.json?f_userOrOld=uploaded%20sample&label=id:node_3577511

@ryhisner @FedeGueli @corneliusroemer

I managed to look into it : HV.1.10 is not this one and has around 100 Seqs , best query i found is : C15720T,C29784T,C22916T

@FedeGueli
Copy link

In january a few of the highly homoplasic HV.1 + 452W are still circualting:
1)HV.1.10
2) the lineage proposed here
3) a lineage stemming out of from the politomy
4) one small lineage found by C22916T,C7788T,T3306A : with Orf1a:E377G, Orf1a:M1014K, Orf1a:A2508V
5) one lineage that Usher shows having a intermediate step with C22916A and then A22916T so likely just a flip flop

@corneliusroemer if you want to take a look: (tree cut with just samples from January , but there are 50+ branches with 452W in HV.1)
https://nextstrain.org/fetch/genome-test.gi.ucsc.edu/trash/ct/singleSubtreeAuspice_genome_test_67132_82d7e0.json?f_userOrOld=uploaded%20sample

@FedeGueli
Copy link

57 one sample from February

@FedeGueli FedeGueli changed the title HV.1 with S:R452W, ORF1a:T4083M (18 seqs - 5 countries - Dec 29 ) HV.1 with S:R452W, ORF1a:T4083M (57 seqs - 7 countries - March 3 ) Mar 3, 2024
@FedeGueli FedeGueli changed the title HV.1 with S:R452W, ORF1a:T4083M (57 seqs - 7 countries - March 3 ) HV.1 with S:R452W, ORF1a:T4083M (60 seqs - 7 countries - March 19) Mar 19, 2024
@FedeGueli
Copy link

still a couple of recent new samples lets keep it open for a while more

@FedeGueli FedeGueli changed the title HV.1 with S:R452W, ORF1a:T4083M (60 seqs - 7 countries - March 19) HV.1 with S:R452W, ORF1a:T4083M (61 seqs - 7 countries - March 19) Apr 5, 2024
@FedeGueli
Copy link

no seuence in March closing it

@FedeGueli FedeGueli closed this as not planned Won't fix, can't repro, duplicate, stale Apr 5, 2024
Sign up for free to join this conversation on GitHub. Already have an account? Sign in to comment
Labels
help wanted Extra attention is needed s:157 S:452 S:456
Projects
None yet
Development

No branches or pull requests

3 participants