New XBB.1.5.57 + N:S194P sublineage with S:F456L appeared in Spain (14 sequences ) #10
Labels
Apparently slow
It means that a lineage is accumulating sequences slowly not that it is intrinsically slow.
Convergent evolution
Lineages with convergent mutations
S:456
I mentioned this one briefly in the main pango github page : cov-lineages/pango-designation#1949 ith @krosa1910, but it has grown further since so a pre proposal is deserved:
Def muts: XBB.1.5.57 + A18333G, N_S194P (T28853C) >> C26681T > C1594T > Orf1a:L2620I (C8123A) >Orf1a:G934S (G3065A) > C1853T, S:F456L (T22928C)
Gisaid Query : N_S194P, Spike_F456L
Sequences: EPI_ISL_17469836, EPI_ISL_17469840, EPI_ISL_17504402,
EPI_ISL_17504404-17504406, EPI_ISL_17505609, EPI_ISL_17505611,
EPI_ISL_17540248, EPI_ISL_17597796, EPI_ISL_17597801,
Tree:
https://nextstrain.org/fetch/genome.ucsc.edu/trash/ct/subtreeAuspice1_genome_395c0_68f9e0.json?c=gt-S_456&label=id:node_5921924
Note that XBB.1.5.57 is in the pre T17124C branch of XBB.1.5 and it is likely the parental lineage of XBL
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