Addiction-associated genetic variants implicate cell type- and region-specific cis-regulatory elements in addiction neurobiology

This repository contains the scripts used to perform the computational analyses in "Addiction-associated genetic variants implicate cell type- and region-specific cis-regulatory elements in addiction neurobiology".

Sequencing output files for data generated in this study are deposited on the GEO at accession GSE161374.

GWAS Analysis

Comparison of genetic architecture of traits defined by GWAS

gwas_correlation

GWAS enrichment of human OCRs

gwas_enrichment

gwas_enrichment_control_foreground

GWAS enrichment of mouse (human-orthologous) OCRs

mouse_enrichment

GWAS enrichment of human cell type-specific OCRs

model_prioritized_fullard_enrichments

ML models for predicting cell type-specific open chromatin

celltype_specific_ml_models

Addiction-associated locus plots

genomeTracks