Acute SARS-CoV-2 infection affects the number of circulating Natural Killer (NK) cells and their phenotype. NK cells dysfunction has been observed in COVID-19 patients with high levels of cytotoxic proteins in NK cells in Severe COVID-19 cases.
Here, we created a workflow to predict COVID-19 disease severity based on NK cell transcriptome expression profiles of Single-cell RNA-seq data from pure NK cells or Peripheral Blood Mononuclear Cells (PBMCs). We followed the SEURAT workflows for the analysis. The input file is a H5 matrix, and the output is a COVID-19 Severity Prediction and .csv file with detailed marker expression information.
Go to the COST, read the instructions, upload your data, press Predict.
