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Better clarify the terms used throughout the PDF report #139

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armish opened this issue Jul 6, 2017 · 0 comments
Open

Better clarify the terms used throughout the PDF report #139

armish opened this issue Jul 6, 2017 · 0 comments
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@armish
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armish commented Jul 6, 2017

Some replacement/addition suggestions that I think will help better clarify some of the fields/terms in the report for a first-time user and/or for an average bfx-savvy researcher:

  • COMMAND LINE ARGUMENTS
    • Include Vaxrank version that is used to generate the report
  • For each variant:
    • Reads supporting ... allele -> DNA reads
    • Reads supporting ... (maybe add what percent this corresponds to?)
    • Top score -> Top vaccine score
  • For each predicted effect:
    • Highlight "Effect description" value using the same colors that you use to highlight the mutant aa within the table header right below
  • For each vaccine peptides for variant X:
    • Length -> Length of the peptide window for searching vaccines
    • Expression score -> add units? FPKM/TPM (optionally: percentile)
    • Mutant amino acids -> Mutant amino acids within the window
    • Mutation distance from edge -> Mutation distance from edge**(s)**
    • Manufacturability -> if possible, add range for each metric?
  • For each Predicted mutant epitopes
    • Table headers:
      • Sequence -> Peptide sequence
      • IC50 -> IC50 (predicted binding affinity of the mutant peptide)
      • Normalized binding score -> Normalized binding score (\frac{IC50_{tumor}}{IC50_{normal}})
      • Maybe move the "Allele" column closer to the "Sequence" one to emphasize that those metrics belong to that particular pair and "Allele" is not a result
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