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Add sambamba to improve the efficiency #14

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likelet opened this issue Jun 6, 2018 · 2 comments
Closed

Add sambamba to improve the efficiency #14

likelet opened this issue Jun 6, 2018 · 2 comments

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@likelet
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likelet commented Jun 6, 2018

May have a think of using sambamba to do sam/bam/cram operation like what I did in LncPipe
for sam->bam conversion
https://github.com/likelet/LncPipe/blob/master/LncRNAanalysisPipe.nf#L592
and bam sort
https://github.com/likelet/LncPipe/blob/master/LncRNAanalysisPipe.nf#L593

hope it helps

@apeltzer
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Is that still a major speed improvement compared to Samtools 1.8? IIRC, Samtools/HTSjdk etc werde updated and parallelized more (which they weren't when sambamba came out). So this could already be negligible... Thanks for the tip though!

@likelet
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likelet commented Jul 19, 2018

sorry, i did not do the comparison between samtools 1.8 and sambamba, i will try it later.
:)

@likelet likelet closed this as completed Jul 19, 2018
jfy133 added a commit that referenced this issue May 14, 2021
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