Update content/10.diagnostics.md

Co-authored-by: HM Rando <[email protected]>

content/10.diagnostics.md

@@ -133,7 +133,7 @@ One study showed that RT-LAMP is effective for detection of SARS-CoV-2 with exce
 This test aims to bring the sensitivity of nucleic acid detection to the point of care or home testing setting. 
 It could be applied for screening, diagnostics, or as a definitive test for people who are positive based on lateral flow tests.
 This method was benchmarked against RT-PCR using 177 human nasopharyngeal RNA samples, of which 126 were COVID positive.
-The authors break down the sensitivity of their test according to the cycle threshold (Ct) value from RT-PCR of the same samples; RT-LAMP performs at 100% sensitivity for samples with a Ct from RT-PCR of 32 or less. 
+The authors break down the sensitivity of their test according to the cycle threshold (C~t~) value from RT-PCR of the same samples; RT-LAMP performs at 100% sensitivity for samples with a C~t~ from RT-PCR of 32 or less. 
 The performance is worse when considering all RT-PCR positive samples (including those with C~t~ values between 32-40).
 However, there is some evidence suggesting that samples obtained from individuals that achieve Ct values >30 measured using RT-PCR tend to be less infective that those that record a Ct value <30 [@doi:10.1016/j.jiph.2021.08.013; @doi:10.1017/ice.2021.132; @doi:10.1093/cid/ciaa619], and so RT-LAMP is still a useful diagnostic tool. 
 Various combinations of reagents are available, but one example of reagents being used are the WarmStart Colorimetric LAMP 2X Master Mix with a set of six primers developed previously by Zhang et al. [@doi:10.1101/2020.02.26.20028373].