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MPH Thesis: Determinants of In-Hospital Child Mortality in Uganda

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mph_thesis_ml

The original paper used logistic regression using backwards selection on a number of binary variables to attempt to predict the risk of childhood mortality. It created a simple binary risk score to aid in calculating a child's probability of death.

My work attempts to extend this analysis by using machine learning analyses to validate this approach and compare it to other analytical methods. In particular, I aim to produce some decision trees to aid in decision-making.

01_clean_data.do:

  • Formats all variables the same way
  • Decide what to do with “9” values
  • Exclude variables that don’t matter
  • Create variable lists: signs, symptoms, treatment, diagnoses, test results, outcomes
  • Turn all variables into binary indicators
    • May need Herbie’s guidance on indicators not included in the original analysis

02_prep_data.R

  • Apply different methods of imputation or observation-dropping
  • Output table of missing variables for all variables of interest
  • Descriptive table of primary patient characteristics
  • Any other descriptive stats

analysis_functions.R

  • Specify one function for each method — assume same data structure, and take in arguments for formula etc.
  • Logistic regression with backwards selection
    • Define variable importance cutoffs for selection (or default)
  • Decision trees
    • Define ideal tree breakdown — pruning characteristics etc.
  • Random forests
    • Source up-sampling/down-sampling methods
  • Define sampling parameters, number of cv runs, etc.
  • Output predictions, graphical representations, ROC analyses.
  • Save graphs, predictions, and ROC analyses to flat files (how to toggle by source?)

03_apply_analysis.R

  • Source all analysis functions
  • Separate data into train and test data
  • Apply analysis functions and get/plot results

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MPH Thesis: Determinants of In-Hospital Child Mortality in Uganda

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