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JN.1 (BA.2.86.1.1) sublineage with S:Q183H (243 seqs) #2410

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HynnSpylor opened this issue Dec 12, 2023 · 13 comments
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JN.1 (BA.2.86.1.1) sublineage with S:Q183H (243 seqs) #2410

HynnSpylor opened this issue Dec 12, 2023 · 13 comments
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@HynnSpylor
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HynnSpylor commented Dec 12, 2023

*Transferred from sars-cov-2-variants/lineage-proposals#1096

Defining mutations: JN.1>G22111T (S:Q183H)
GISAID query: G11727A, G22111T, T22926C
Earliest seq: 2023-10-25 (NY, US- EPI_ISL_18499187)
Most recent seq: 2023-12-03 (England, UK- EPI_ISL_18613217)
Countries detected: US (11), UK (10), Canada (6), Japan (2), Sweden (1), Spain (1), Singapore (1)
Usher Tree:
联想截图_20231213014604

https://nextstrain.org/fetch/genome.ucsc.edu/trash/ct/subtreeAuspice1_genome_28fae_895240.json
Notice that S:Q183E is for XBB* lineages. Now JN.1+S:Q183H branch is circulating and we can track it for a time.

Genomes:
EPI_ISL_18499187, EPI_ISL_18499266, EPI_ISL_18504314, EPI_ISL_18505101, EPI_ISL_18513037, EPI_ISL_18517615, EPI_ISL_18520852, EPI_ISL_18520856, EPI_ISL_18545705, EPI_ISL_18553101, EPI_ISL_18577828, EPI_ISL_18578276, EPI_ISL_18578341, EPI_ISL_18578369, EPI_ISL_18578447, EPI_ISL_18581364, EPI_ISL_18581366, EPI_ISL_18581377, EPI_ISL_18581447, EPI_ISL_18583095, EPI_ISL_18583284,
EPI_ISL_18583618, EPI_ISL_18587072, EPI_ISL_18590592, EPI_ISL_18593967, EPI_ISL_18599087, EPI_ISL_18601535, EPI_ISL_18610802, EPI_ISL_18611837, EPI_ISL_18613217, EPI_ISL_18613273, EPI_ISL_18614468

@HynnSpylor
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44 seqs now

@HynnSpylor HynnSpylor changed the title JN.1 (BA.2.86.1.1) sublineage with S:Q183H (32 seqs in 7 countries) JN.1 (BA.2.86.1.1) sublineage with S:Q183H (44 seqs in 7 countries) Dec 16, 2023
@FedeGueli
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73 now!

@HynnSpylor
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HynnSpylor commented Dec 19, 2023

71 seqs now and it seems quite fast

@HynnSpylor HynnSpylor changed the title JN.1 (BA.2.86.1.1) sublineage with S:Q183H (44 seqs in 7 countries) JN.1 (BA.2.86.1.1) sublineage with S:Q183H (71 seqs in 8 countries) Dec 19, 2023
@HynnSpylor HynnSpylor changed the title JN.1 (BA.2.86.1.1) sublineage with S:Q183H (71 seqs in 8 countries) JN.1 (BA.2.86.1.1) sublineage with S:Q183H (73 seqs in 8 countries) Dec 19, 2023
@HynnSpylor HynnSpylor changed the title JN.1 (BA.2.86.1.1) sublineage with S:Q183H (73 seqs in 8 countries) JN.1 (BA.2.86.1.1) sublineage with S:Q183H (101 seqs in 9 countries) Dec 23, 2023
@HynnSpylor
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121 seqs!

@HynnSpylor HynnSpylor changed the title JN.1 (BA.2.86.1.1) sublineage with S:Q183H (101 seqs in 9 countries) JN.1 (BA.2.86.1.1) sublineage with S:Q183H (121 seqs in 9 countries) Dec 26, 2023
@HynnSpylor HynnSpylor changed the title JN.1 (BA.2.86.1.1) sublineage with S:Q183H (121 seqs in 9 countries) JN.1 (BA.2.86.1.1) sublineage with S:Q183H (156 seqs in 9 countries) Dec 27, 2023
@HynnSpylor
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243 seqs now!
There is also a branch with S:T572I (8 seqs in 3 countries), which is also popular in JN.1* seqs
联想截图_20240106232620

@HynnSpylor HynnSpylor changed the title JN.1 (BA.2.86.1.1) sublineage with S:Q183H (156 seqs in 9 countries) JN.1 (BA.2.86.1.1) sublineage with S:Q183H (243 seqs) Jan 6, 2024
@FedeGueli
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i bet it will be the first Cornelius' choice when he will be back.

@FedeGueli
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@HynnSpylor i m checking but this should have a S:t572I sublineage wait a min

@FedeGueli
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Screenshot 2024-01-06 alle 23 25 53 Here we come ! it has not only S:T572I but also the EG.5.1 defining Orf1a:A3143V! and it is not small i will track it in https://github.com/sars-cov-2-variants/lineage-proposals/issues/1097 but please add it here in this proposal!

@HynnSpylor
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@FedeGueli Thx for pointing out the evolution! I forgot to mention it.
As S:Q183H and S:T572I are two most popular Spike mutations in JN.1* now, the branch may be remarkable.

@corneliusroemer
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JN.1.9

@HynnSpylor
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Thx @corneliusroemer
Now the T572I branch also reaches 11

@HynnSpylor
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Now JN.1.9 with S:T572I reaches 35. I suggest to open a new issue to track it.

@FedeGueli
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Now JN.1.9 with S:T572I reaches 35. I suggest to open a new issue to track it.

i think it is tracked in the multiple lineage issue about Jn.1 + 572I

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