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Defining mutations: BQ.1.1.35>T9619C>A22108T (S:K182N)
GISAID query: Spike_R346T, Spike_K444T, Spike_F486V, Spike_K147E, Spike_K182N
Cov-spectrum query: BQ.1.1.35 + S:K182N
Earliest seq: 2022-11-23 (Netherland, EPI_ISL_16202528)
Most recent seq: 2023-02-21 (Austria, EPI_ISL_17082550)
Countries Detected: UK (130), Austria (19), Belgium (14), Netherland (9), Germany (8), France (4), Finland (1), Sweden (1)
Usher Tree:
https://nextstrain.org/fetch/genome.ucsc.edu/trash/ct/subtreeAuspice1_genome_3f370_5d3600.json
When I proposed the CH.1.1 sublineage with S:K182N (#1726), I noted lots of Pangolin "unassigned" sequences with S:K444T, S:L452R and S:K182N. Some of them were of CH.1.1+S: K182N sublineage, but others were BA.5-like Spike. Now Usher tree confirms that most of them belong to sublineage of BQ.1.1.35 (BQ.1.1+S:K147E).
(S: K182N mutation is based on nuc: A22108T in this BQ.1.1.35 sublineage, while A22108C in CH.1.1+S: K182N sublineage).
Defining mutations: BQ.1.1.35>T9619C>A22108T (S:K182N)
GISAID query: Spike_R346T, Spike_K444T, Spike_F486V, Spike_K147E, Spike_K182N
Cov-spectrum query: BQ.1.1.35 + S:K182N
Earliest seq: 2022-11-23 (Netherland, EPI_ISL_16202528)
Most recent seq: 2023-02-21 (Austria, EPI_ISL_17082550)
Countries Detected: UK (130), Austria (19), Belgium (14), Netherland (9), Germany (8), France (4), Finland (1), Sweden (1)
Usher Tree:
https://nextstrain.org/fetch/genome.ucsc.edu/trash/ct/subtreeAuspice1_genome_3f370_5d3600.json
When I proposed the CH.1.1 sublineage with S:K182N (#1726), I noted lots of Pangolin "unassigned" sequences with S:K444T, S:L452R and S:K182N. Some of them were of CH.1.1+S: K182N sublineage, but others were BA.5-like Spike. Now Usher tree confirms that most of them belong to sublineage of BQ.1.1.35 (BQ.1.1+S:K147E).
(S: K182N mutation is based on nuc: A22108T in this BQ.1.1.35 sublineage, while A22108C in CH.1.1+S: K182N sublineage).
Cov-spectrum relative growth rate shows slight advantage to parent lineage (BQ.1.1.35)
https://cov-spectrum.org/explore/World/AllSamples/Past3M/variants?nextcladePangoLineage=BQ.1.1.35*&aaMutations1=S%3AK182N&nextcladePangoLineage1=BQ.1.1.35*&analysisMode=CompareToBaseline&
Genomes:
Genomes.txt
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