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chenxi199506 committed Jul 5, 2024
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# SPARKLE - Single-cell Phenotype Association Research Kit for Large-scale dataset Exploration

SPARKLE is based on generalized linear mixed models (GLMM) for large-scale single-cell cell-phenotype association analysis. SPARKLE supports the flexibly inclusion of metadata variables as covariates to mitigate the impact of heterogeneity on result accuracy.<img src='https://github.com/chenxi199506/SPARKLE/blob/master/tutorial/figure/pic1.png' align="right" height="138" /></a>
![pic](https://github.com/chenxi199506/SPARKLE/blob/master/tutorial/figure/logo2.png)

# SPARKLE - Single-cell Phenotype Association Research Kit for Large-scale dataset Exploration![pic](https://github.com/chenxi199506/SPARKLE/blob/master/tutorial/figure/logo1.png)

SPARKLE is based on generalized linear mixed models (GLMM) for large-scale single-cell cell-phenotype association analysis. SPARKLE supports the flexibly inclusion of metadata variables as covariates to mitigate the impact of heterogeneity on result accuracy.


![pic](https://github.com/chenxi199506/SPARKLE/blob/master/tutorial/figure/pic1.png)
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SPARKLE provides 4 cases for users. All data involves in the cases were in the package.

[01 Supported Data Input Formats](https://rpubs.com/chenxi/1202118)
[Tutorials 01 Supported Data Input Formats](https://rpubs.com/chenxi/1202118)

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