05 interventions

Four interventions are currently available: human mass drug administration (eg, using praziquantel or niclosamide), pig mass drug administration (eg, using oxfendazole), pig vaccination, and combined pig mass drug administration and vaccination. These interventions can be implemented alone or in combination.

Human MDA

Implementation

do_man_mda(x, coverage, efficacy, min.age = 0, max.age = Inf)

Arguments

x	cystiRun object.
coverage	Presumed coverage of drug treatment within eligible population, expressed as a decimal value.
efficacy	Presumed efficacy of drug treatment, expressed as a decimal value.
min.age	Minimum age for MDA, in months. Defaults to 1, i.e., no lower age limit
max.age	Maximum age for MDA, in months. Defaults to Inf, i.e., no upper age limit.

Details

• Eligible HT: have Taenia (mature, immature) and eligible age
• Effective treatment is randomized based on efficacy and coverage, within eligible group
• Both mature and immature TW die
• Time since infection set to zero
• Time since contamination set to one: initiates decay of environmental contamination

Pig MDA

Implementation

do_pig_mda(x, coverage, efficacy, immunity = 3, min.age = 1, max.age = Inf)

Arguments

x	cystiRun object.
coverage	Presumed coverage of drug administration within eligible population, expressed as a decimal value.
efficacy	Presumed efficacy of drug treatment, expressed as a decimal value.
immunity	Presumed duration of immunity following drug treatment of an infected pig. Defaults to 3 months.
min.age	Minimum age for MDA, in months. Defaults to 1 month.
max.age	Maximum age for MDA, in months. Defaults to Inf, i.e., no upper age limit.

Details

• Eligible PC: have cyst (mature, immature) and eligible age
• Effective treatment is randomized based on coverage and efficacy, within eligible group
• Both mature and immature cysts die
• Immunity is generated for treated positive pigs (mature & immature)
• Intensity and time since infection set to zero

Pig Vaccination

Implementation

do_pig_vac(x, coverage, efficacy, immunity = Inf, interval = 4,
           min.age = 1, max.age = Inf)

Arguments

x	cystiRun object.
coverage	Presumed coverage of vaccination within eligible population, expressed as a decimal value.
efficacy	Presumed efficacy of vaccine, expressed as a decimal value.
immunity	Presumed duration of immunity following successful vaccination. Defaults to Inf.
interval	Maximum interval between two consecutive shots for immunity. Defaults to 4 months.
min.age	Minimum age for vaccination, in months. Defaults to 1 month.
max.age	Maximum age for vaccination, in months. Defaults to Inf, i.e., no upper age limit.

Details

• Eligible PC: has eligible age
• Effective vaccination is randomized based on coverage and efficacy, within eligible group
• If first vaccination or previous vaccination more than interval months ago, time since vaccination gets set to interval+1; this counter will be decreased by 1 step at each iteration
• Immunity is generated for pigs that were vaccinated less than interval months ago

Pig MDA and vaccination

Implementation

do_pig_mda_vac(x, coverage, efficacy.mda, efficacy.vac,
               immunity.mda = 3, immunity.vac = Inf, interval = 4,
               min.age = 1, max.age = Inf)

Arguments

x	cystiRun object.
coverage	Presumed coverage within eligible population, expressed as a decimal value.
efficacy.mda	Presumed efficacy of drug treatment, expressed as a decimal value.
efficacy.vac	Presumed efficacy of vaccination, expressed as a decimal value.
immunity.mda	Presumed duration of immunity following drug treatment of an infected pig. Defaults to 3 months.
immunity.vac	Presumed duration of immunity following successful vaccination. Defaults to Inf.
interval	Maximum interval between two consecutive shots for immunity. Defaults to 4 months.
min.age	Minimum age for interventions, in months. Defaults to 1 month.
max.age	Maximum age for interventions, in months. Defaults to Inf, i.e., no upper age limit.

Details

• Same assumptions as do_pig_mda and do_pig_vac
• Selected animals receive for both interventions, reflecting the perfect correlation between coverage for MDA and vaccination