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templates: refine for treats-templates with gene intermediates
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52 changes: 52 additions & 0 deletions
52
data/templates/Drug-treats-Disease/Chem-decreaseGeneWithFunctionGainIn-Disease.json
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| Original file line number | Diff line number | Diff line change |
|---|---|---|
| @@ -0,0 +1,52 @@ | ||
| { | ||
| "message": { | ||
| "query_graph": { | ||
| "nodes": { | ||
| "creativeQuerySubject": { | ||
| "categories":["biolink:ChemicalEntity"] | ||
| }, | ||
| "nA": { | ||
| "categories":["biolink:Gene"], | ||
| "is_set": true | ||
| }, | ||
| "creativeQueryObject": { | ||
| "categories":["biolink:DiseaseOrPhenotypicFeature"] | ||
| } | ||
| }, | ||
| "edges": { | ||
| "eA": { | ||
| "subject": "creativeQuerySubject", | ||
| "object": "nA", | ||
| "qualifier_constraints": [ | ||
| { | ||
| "qualifier_set": [ | ||
| { | ||
| "qualifier_type_id": "biolink:object_direction_qualifier", | ||
| "qualifier_value": "decreased" | ||
| }, | ||
| { | ||
| "qualifier_type_id": "biolink:object_aspect_qualifier", | ||
| "qualifier_value": "activity_or_abundance" | ||
| } | ||
| ] | ||
| } | ||
| ] | ||
| }, | ||
| "eB": { | ||
| "subject": "nA", | ||
| "object": "creativeQueryObject", | ||
| "qualifier_constraints": [ | ||
| { | ||
| "qualifier_set": [ | ||
| { | ||
| "qualifier_type_id": "biolink:subject_form_or_variant_qualifier", | ||
| "qualifier_value": "gain_of_function_variant_form" | ||
| } | ||
| ] | ||
| } | ||
| ] | ||
| } | ||
| } | ||
| } | ||
| } | ||
| } |
52 changes: 52 additions & 0 deletions
52
data/templates/Drug-treats-Disease/Chem-increaseGeneWithFunctionLossIn-Disease.json
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| Original file line number | Diff line number | Diff line change |
|---|---|---|
| @@ -0,0 +1,52 @@ | ||
| { | ||
| "message": { | ||
| "query_graph": { | ||
| "nodes": { | ||
| "creativeQuerySubject": { | ||
| "categories":["biolink:ChemicalEntity"] | ||
| }, | ||
| "nA": { | ||
| "categories":["biolink:Gene"], | ||
| "is_set": true | ||
| }, | ||
| "creativeQueryObject": { | ||
| "categories":["biolink:DiseaseOrPhenotypicFeature"] | ||
| } | ||
| }, | ||
| "edges": { | ||
| "eA": { | ||
| "subject": "creativeQuerySubject", | ||
| "object": "nA", | ||
| "qualifier_constraints": [ | ||
| { | ||
| "qualifier_set": [ | ||
| { | ||
| "qualifier_type_id": "biolink:object_direction_qualifier", | ||
| "qualifier_value": "increased" | ||
| }, | ||
| { | ||
| "qualifier_type_id": "biolink:object_aspect_qualifier", | ||
| "qualifier_value": "activity_or_abundance" | ||
| } | ||
| ] | ||
| } | ||
| ] | ||
| }, | ||
| "eB": { | ||
| "subject": "nA", | ||
| "object": "creativeQueryObject", | ||
| "qualifier_constraints": [ | ||
| { | ||
| "qualifier_set": [ | ||
| { | ||
| "qualifier_type_id": "biolink:subject_form_or_variant_qualifier", | ||
| "qualifier_value": "loss_of_function_variant_form" | ||
| } | ||
| ] | ||
| } | ||
| ] | ||
| } | ||
| } | ||
| } | ||
| } | ||
| } |
33 changes: 33 additions & 0 deletions
33
...s/Drug-treats-Disease/Chem-regulates,affects-Gene-biomarker,associated_condition-DoP.json
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| Original file line number | Diff line number | Diff line change |
|---|---|---|
| @@ -0,0 +1,33 @@ | ||
| { | ||
| "message": { | ||
| "query_graph": { | ||
| "nodes": { | ||
| "creativeQuerySubject": { | ||
| "categories":["biolink:ChemicalEntity"] | ||
| }, | ||
| "nA": { | ||
| "categories":["biolink:Gene"], | ||
| "is_set": true | ||
| }, | ||
| "creativeQueryObject": { | ||
| "categories":["biolink:DiseaseOrPhenotypicFeature"] | ||
| } | ||
| }, | ||
| "edges": { | ||
| "eA": { | ||
| "subject": "creativeQuerySubject", | ||
| "object": "nA", | ||
| "predicates": ["biolink:regulates", "biolink:affects"] | ||
| }, | ||
| "eB": { | ||
| "subject": "nA", | ||
| "object": "creativeQueryObject", | ||
| "predicates": [ | ||
| "biolink:gene_associated_with_condition", | ||
| "biolink:biomarker_for" | ||
| ] | ||
| } | ||
| } | ||
| } | ||
| } | ||
| } |