feat: Disable "server" buttons for anonymous users (#391)

backend/app/api/internal/endpoints/remote.py

@@ -178,9 +178,6 @@ async def cnv_acmg(request: Request):
         data={"chromosome": chromosome, "start": start, "end": end, "func": func, "error": 0},
     )
     backend_resp = await client.send(backend_req)
-    if backend_resp.status_code != 200:
-        return Response(status_code=backend_resp.status_code, content=backend_resp.content)
-
     if backend_resp.status_code != 200:
         return Response(status_code=backend_resp.status_code, content=backend_resp.content)
     return JSONResponse(backend_resp.json())

frontend/src/components/SeqvarDetails/ClinsigCard.vue

@@ -23,6 +23,7 @@ import {
 import { type Seqvar } from '@/lib/genomicVars'
 import { StoreState } from '@/stores/misc'
 import { useSeqvarAcmgRatingStore } from '@/stores/seqvarAcmgRating'
+import { useUserStore } from '@/stores/user'
 
 /** Data type used for component's props. */
 interface Props {
@@ -41,6 +42,9 @@ const emit = defineEmits<{
 /** Store to use for ACMG ratings of sequence variants. */
 const acmgRatingStore = useSeqvarAcmgRatingStore()
 
+/** Store for user data. */
+const userStore = useUserStore()
+
 /** Component state: error message to display, if any. */
 const errorMessage = ref<string>('')
 /** Component state: whether to enable summary view. */
@@ -172,6 +176,7 @@ watch(
 
 /** Fetch ACMG rating when mounted. */
 onMounted(async () => {
+  userStore.initialize()
   if (props.seqvar?.genomeBuild === 'grch37') {
     const seqvar = props.seqvar // so that it is not undefined in the async function
     await tryCatchEmitErrorDisplay(async () => await acmgRatingStore.fetchAcmgRating(seqvar))
@@ -257,6 +262,7 @@ onMounted(async () => {
         <v-col cols="6">
           <SummarySheet
             :calculated-acmg-class="calculatedAcmgClass"
+            :inter-var-available="acmgRatingStore.acmgRatingIntervarLoaded"
             @clear-all="() => unfetchAcmgRating()"
             @reset-to-auto="() => refetchAcmgRatingInterVar()"
           />
@@ -268,6 +274,7 @@ onMounted(async () => {
               variant="text"
               rounded="sm"
               prepend-icon="mdi-cloud-upload-outline"
+              :disabled="!userStore.isAuthenticated"
               @click="() => saveAcmgRating()"
             >
               Save to Server
@@ -277,6 +284,7 @@ onMounted(async () => {
               variant="text"
               rounded="sm"
               prepend-icon="mdi-cloud-download-outline"
+              :disabled="!userStore.isAuthenticated"
               @click="() => refetchAcmgRatingServer()"
             >
               Load from Server
@@ -286,6 +294,7 @@ onMounted(async () => {
               variant="text"
               rounded="sm"
               prepend-icon="mdi-cloud-remove-outline"
+              :disabled="!userStore.isAuthenticated"
               @click="() => deleteAcmgRating()"
             >
               Delete from Server

frontend/src/components/SeqvarDetails/ClinsigCard/SummarySheet.vue

@@ -3,11 +3,13 @@ import { classColor } from '@/lib/utils'
 
 interface Props {
   calculatedAcmgClass?: string
+  interVarAvailable?: boolean
 }
 
 // eslint-disable-next-line @typescript-eslint/no-unused-vars
 const props = withDefaults(defineProps<Props>(), {
-  calculatedAcmgClass: 'N/A'
+  calculatedAcmgClass: 'N/A',
+  interVaravailable: false
 })
 
 const emit = defineEmits(['clearAll', 'resetToAuto'])
@@ -38,6 +40,7 @@ const emit = defineEmits(['clearAll', 'resetToAuto'])
         variant="text"
         rounded="sm"
         prepend-icon="mdi-file-restore-outline"
+        :disabled="!interVarAvailable"
         @click="emit('resetToAuto')"
       >
         Reset to InterVar

frontend/src/stores/seqvarAcmgRating.ts

@@ -10,6 +10,7 @@ import { InterVarClient } from '@/api/intervar'
 import {
   ALL_ACMG_CRITERIA,
   AcmgCriteria,
+  AcmgEvidenceLevel,
   MultiSourceAcmgCriteriaState,
   Presence,
   StateSource
@@ -98,6 +99,9 @@ export const useSeqvarAcmgRatingStore = defineStore('seqvarAcmgRating', () => {
     // Load data from InterVar via API
     storeState.value = StoreState.Loading
 
+    // Set the variant
+    seqvar.value = seqvar$
+
     // Fetch the ACMG rating from InterVar
     try {
       const client = new InterVarClient()
@@ -232,7 +236,7 @@ export const useSeqvarAcmgRatingStore = defineStore('seqvarAcmgRating', () => {
       throw new Error('Cannot save ACMG rating without a variant.')
     }
     const seqvarImpl = seqvarImplFromSeqvar(seqvar.value)
-    const acmgRating = transformAcmgRating()
+    const acmgRatingServer = transformAcmgRating()
 
     try {
       const acmgSeqvarClient = new AcmgSeqVarClient()
@@ -242,9 +246,23 @@ export const useSeqvarAcmgRatingStore = defineStore('seqvarAcmgRating', () => {
         acmgSeqvar.detail !== 'ACMG Sequence Variant not found' &&
         acmgSeqvar.detail !== 'Not Found'
       ) {
-        await acmgSeqvarClient.updateAcmgRating(seqvarImpl, acmgRating)
+        await acmgSeqvarClient.updateAcmgRating(seqvarImpl, acmgRatingServer)
       } else {
-        await acmgSeqvarClient.saveAcmgRating(seqvarImpl, acmgRating)
+        await acmgSeqvarClient.saveAcmgRating(seqvarImpl, acmgRatingServer)
+      }
+      // Go through the data and setPresense for each criteria
+      for (const criteria of acmgRatingServer.criterias) {
+        const criteriaKey = criteria.criteria as keyof typeof AcmgCriteria
+        acmgRating.value.setPresence(
+          StateSource.Server,
+          AcmgCriteria[criteriaKey],
+          criteria.presence as Presence
+        )
+        acmgRating.value.setEvidenceLevel(
+          StateSource.Server,
+          AcmgCriteria[criteriaKey],
+          criteria.evidence as AcmgEvidenceLevel
+        )
       }
       acmgRatingStatus.value = true
     } catch (e) {
@@ -266,6 +284,10 @@ export const useSeqvarAcmgRatingStore = defineStore('seqvarAcmgRating', () => {
     try {
       const acmgSeqvarClient = new AcmgSeqVarClient()
       await acmgSeqvarClient.deleteAcmgRating(seqvarImpl)
+      // Go through the data and setPresense for each criteria
+      for (const criteria of ALL_ACMG_CRITERIA) {
+        acmgRating.value.setPresence(StateSource.Server, criteria, Presence.Unknown)
+      }
       acmgRatingStatus.value = false
     } catch (e) {
       throw new Error(`There was an error deleting the ACMG data: ${e}`)