Trying something out.

pants.remote.ini

@@ -44,8 +44,8 @@ interpreter_search_paths: [
      # side, and this can cause pex bootstrapping to fail (for unclear reasons).
      # The /pyenv-docker-build/ paths are unlikely to exist on local systems, and so will not interfere with interpreter
      # discovery there.  This emphasizes that we should fix #7735, and not commingle the paths of two unrelated systems.
-     '<PATH>',
-     '<PEXRC>',
+     #'<PATH>',
+     #'<PEXRC>',
   ]
 
 [python-native-code]

src/python/pants/backend/python/rules/pex.py

@@ -14,7 +14,7 @@
   DirectoriesToMerge,
   DirectoryWithPrefixToAdd,
 )
-from pants.engine.isolated_process import ExecuteProcessResult, MultiPlatformExecuteProcessRequest
+from pants.engine.isolated_process import ExecuteProcessResult, ExecuteProcessRequest
 from pants.engine.legacy.structs import PythonTargetAdaptor, TargetAdaptor
 from pants.engine.platform import Platform, PlatformConstraint
 from pants.engine.rules import rule, subsystem_rule
@@ -128,23 +128,18 @@ async def create_pex(
   # (execution_platform_constraint, target_platform_constraint) of this dictionary is "The output of
   # this command is intended for `target_platform_constraint` iff it is run on `execution_platform
   # constraint`".
-  execute_process_request = MultiPlatformExecuteProcessRequest(
-    {
-      (PlatformConstraint(platform.value), PlatformConstraint(platform.value)):
-        pex_bin.create_execute_request(
-          python_setup=python_setup,
-          subprocess_encoding_environment=subprocess_encoding_environment,
-          pex_build_environment=pex_build_environment,
-          pex_args=argv,
-          input_files=merged_digest,
-          description=f"Create a requirements PEX: {', '.join(request.requirements.requirements)}",
-          output_files=(request.output_filename,)
-        )
-    }
+  execute_process_request = pex_bin.create_execute_request(
+    python_setup=python_setup,
+    subprocess_encoding_environment=subprocess_encoding_environment,
+    pex_build_environment=pex_build_environment,
+    pex_args=argv,
+    input_files=merged_digest,
+    description=f"Create a requirements PEX: {', '.join(request.requirements.requirements)}",
+    output_files=(request.output_filename,)
   )
 
   result = await Get[ExecuteProcessResult](
-    MultiPlatformExecuteProcessRequest,
+    ExecuteProcessRequest,
     execute_process_request
   )
   return Pex(directory_digest=result.output_directory_digest, output_filename=request.output_filename)