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@akikuno akikuno released this 16 Jul 04:40
· 36 commits to main since this release
0.5.3
5f08dce
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Learn about vigilant mode.

💥 Breaking

  • Update clustering.clustering: Use Constrained Kmeans clustering to address the issue of cluster imbalance where extremely minor clusters were preferentially separated. Set min_cluster_size to 0.5% of the sample read count. [Commit Detail]

    • As a result, clustering.label_merger.py is no longer needed and has been removed.

  • Update consensus.call_consensus: For mutations determined to be sequence errors, we previously replaced them with unknown (N), but this N had low interpretability. Therefore, mutations that DAJIN2 determines to be sequence errors will now be assigned the same base as the reference genome. [Commit Detail]

🐛 Bug Fixes

  • Due to a bias in classifiler.calc_match where alleles with shorter sequences were prioritized, the operation of dividing by sequence length has been removed. [Commit Detail]

  • Fix preporcess.mapping.generate_sam to perform alignments with map-ont and splice in addition to sr for sequence lengths of 500 bp or less, and select the optimal prefix from these alignments. Issue: #45 [Commit Detail]

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