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Fix: GPR curation for subsystems related with amino acid #936

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merged 4 commits into from
Dec 16, 2024

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JHL-452b
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@JHL-452b JHL-452b commented Dec 7, 2024

Main improvements in this PR:

As proposed in #891

  • Remove ENSG00000134333 from MAR04287;
  • Remove ENSG00000133048 from MAR08375;
  • Remove ENSG00000159423 from MAR00088;
  • Remove ENSG00000181652 from MAR03995;
  • Remove ENSG00000165672 from MAR04120;
  • Remove ENSG00000138801, ENSG00000198682 from MAR07128;
  • Remove ENSG00000165996, ENSG00000206527 from MAR05288;
  • Remove ENSG00000128683 from MAR04174;
  • Remove ENSG00000006695 from MAR05337;
  • Remove ENSG00000181652 from the model as it's not connected with any reactions after this curation.

I hereby confirm that I have:

  • Tested my code on my own computer for running the model
  • Selected develop as a target branch
  • Any removed reactions and metabolites have been moved to the corresponding deprecated identifier lists

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github-actions bot commented Dec 7, 2024

This PR has been automatically tested with GH Actions. Here is the output of the MACAW test:

Starting dead-end test...
- Found 1514 dead-end metabolites.
- Found 1319 reactions incapable of sustaining steady-state fluxes in either direction due to these dead-ends.
- Found 1977 reversible reactions that can only carry steady-state fluxes in a single direction due to dead-ends.
Starting duplicate test...
- Skipping redox duplicates because no redox_pairs and/or proton_ids were provided.
- Found 447 reactions that were some type of duplicate:
- 0 were completely identical to at least one other reaction.
- 13 involve the same metabolites but go in the opposite direction or have the opposite reversibility as at least one other reaction.
- 447 involve the same metabolites but with different coefficients as at least one other reaction.

This and a more detailed output from MACAW are also committed to data/macawResults/.

Note: In the case of multiple test runs, this post will be edited.

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hhl-24 commented Dec 11, 2024

LGTM!

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3 participants