Cytosolic metabolites in mitochondrial non-transport reactions

[pranasag]

Current behavior:

I spotted a couple of iffy reactions, where 1 metabolite is cytosolic for reactions that take place in mitochondria. These are MAR08433 and MAR08434. In the future, maybe we can write a small script to find potentially problematic reactions like that.

Suggested curation:

1. Check the metabolites for which we should swap mito > cyto - whether the reactions were blocked, or will be if we change that metabolite;
2. Change cytosolic mets into mitochondrial ones.

[edkerk]

Well spotted, and thanks for reporting. It would indeed make sense to write a function to identify potential incorrect reactions.

For those two reactions specifically though, the use of the cytosolic variant was done on purpose (#683, #714), as an intermediate step of a thorough curation of lipoid acid metabolism. The final step (#685) is solved in an open PR (#830), which should be reviewed in the near future.

I'll leave this Issue open, considering the more general script that can identify such potential problematic reactions.

[pranasag]

Thanks a lot Eduard - I did not cross-check with existing issues/PRs indeed, my bad. Yes, it seems we have quite a body of proposed curation that should be implemented and/or reviewed soon.