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Follow-up on #527: I recently reran the same bit of Python code I used to identify all the reactions mentioned in #527 (and fixed in #557) on the latest version of Human-GEM, and it came up with a few more reactions:
ID
Reaction
Proposed Change
MAR02786
ATP + CoA + linoleate <=> AMP + linoleoyl-CoA + PPi
set lower bound to 0
MAR02802
ATP + CoA + linoleate <=> AMP + linoleoyl-CoA + PPi
set lower bound to 0
MAR03388
ATP + CoA + phytanic acid <=> AMP + PPi + 3(S)-Phytanoyl Coenzyme A
set lower bound to 0
MAR03390
ATP + CoA + pristanic acid <=> (2R)-pristanoyl-CoA + AMP + PPi
set lower bound to 0
MAR09508
(5)ppPur-mRNA + GTP <=> G(5)pppR-RNA + PPi
set lower bound to 0
MAR01845
AMP + glycolithocholate + H+ + PPi <=> ATP + glycine + lithocholate
swap products & reactants, then set lower bound to 0
MAR09523
PPi + tRNA containing 6-isopentenyladenosine <=> dimethylallyl-PP + tRNA
swap products & reactants, then set lower bound to 0
MAR09546
AMP + PPi + RNA-terminal-2,3-cyclic-phosphate <=> ATP + RNA-3-terminal-phosphate
swap products & reactants, then set lower bound to 0
See #527 for a more thorough explanation, but all of these reactions should be irreversible in the direction that consumes PPi due to the ubiquitous abundant expression of highly-active pyrophosphatases. I have no idea why they weren't caught the first time (none of these reactions appear to have been edited or created since #557 was merged), but these should all be made irreversible for all the same reasons mentioned in #527.
I've already opened #641 to implement the proposed changes
The text was updated successfully, but these errors were encountered:
Follow-up on #527: I recently reran the same bit of Python code I used to identify all the reactions mentioned in #527 (and fixed in #557) on the latest version of Human-GEM, and it came up with a few more reactions:
See #527 for a more thorough explanation, but all of these reactions should be irreversible in the direction that consumes PPi due to the ubiquitous abundant expression of highly-active pyrophosphatases. I have no idea why they weren't caught the first time (none of these reactions appear to have been edited or created since #557 was merged), but these should all be made irreversible for all the same reasons mentioned in #527.
I've already opened #641 to implement the proposed changes
The text was updated successfully, but these errors were encountered: