Merge pull request #713 from SysBioChalmers/fix/dhodh_rxns

Fix DHODH Reactions
SysBioChalmers · Oct 31, 2023 · b5ce9c9 · b5ce9c9
2 parents 589821a + 1c0a637
commit b5ce9c9
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Showing 3 changed files with 30 additions and 2 deletions.
diff --git a/model/Human-GEM.yml b/model/Human-GEM.yml
@@ -66625,6 +66625,14 @@
       - charge: 0
       - inchis: ""
       - metFrom: ""
+    - !!omap
+      - id: "MAM20019c"
+      - name: "FMNH2"
+      - compartment: "c"
+      - formula: "C17H21N4O9P"
+      - charge: -2
+      - inchis: ""
+      - metFrom: ""
     - !!omap
       - id: "MAM20019r"
       - name: "FMNH2"
@@ -74256,9 +74264,9 @@
       - name: "(S)-dihydroorotate:NAD+ oxidoreductase"
       - metabolites: !!omap
           - MAM00180c: -1
+          - MAM01828c: -1
           - MAM02659c: 1
-          - MAM03102m: 1
-          - MAM03103m: -1
+          - MAM20019c: 1
       - lower_bound: -1000
       - upper_bound: 1000
       - gene_reaction_rule: "ENSG00000102967"
@@ -305179,6 +305187,24 @@
       - subsystem:
           - "Transport reactions"
       - confidence_score: 0
+    - !!omap
+      - id: "MAR20167"
+      - name: "MAR20167"
+      - metabolites: !!omap
+          - MAM01828c: 1
+          - MAM03102m: 1
+          - MAM03103m: -1
+          - MAM20019c: -1
+      - lower_bound: -1000
+      - upper_bound: 1000
+      - gene_reaction_rule: "ENSG00000102967"
+      - rxnNotes: ""
+      - rxnFrom: ""
+      - eccodes: ""
+      - references: "PMID:34428349"
+      - subsystem:
+          - "Miscellaneous"
+      - confidence_score: 0
     - !!omap
       - id: "MAR20168"
       - name: "MAR20168"

diff --git a/model/metabolites.tsv b/model/metabolites.tsv
@@ -8331,6 +8331,7 @@ mets	metsNoComp	metBiGGID	metKEGGID	metHMDBID	metChEBIID	metPubChemID	metLipidMa
 "MAM20021i"	"MAM20021"	""	""	""	"CHEBI:132024"	""	""	""	""	""	"MNXM163133"	""	""
 "MAM02040i"	"MAM02040"	""	""	""	"CHEBI:15377"	""	""	""	""	""	"WATER"	""	""
 "MAM02630i"	"MAM02630"	""	""	""	"CHEBI:15379"	""	""	""	""	""	"MNXM735438"	""	""
+"MAM20019c"	"MAM20019"	"C01847"	""	""	"CHEBI:57618"	""	""	""	""	""	"MNXM1107623"	""	""
 "MAM20019i"	"MAM20019"	"C01847"	""	""	"CHEBI:57618"	""	""	""	""	""	"MNXM1107623"	""	"MAM20022i"
 "MAM01828i"	"MAM01828"	"C00061"	""	""	"CHEBI:58210"	""	""	""	""	""	"MNXM1105928"	""	"MAM20023i"
 "MAM02457i"	"MAM02457"	""	""	""	"CHEBI:78043"	""	""	""	""	""	"MNXM735122"	""	""

diff --git a/model/reactions.tsv b/model/reactions.tsv
@@ -12991,4 +12991,5 @@ rxns	rxnKEGGID	rxnBiGGID	rxnEHMNID	rxnHepatoNET1ID	rxnREACTOMEID	rxnRecon3DID	rx
 "MAR20164"	""	""	""	""	""	""	""	""	""	""	0	""	""	""
 "MAR20165"	""	""	""	""	""	""	""	""	""	""	0	""	""	""
 "MAR20166"	""	""	""	""	""	""	""	""	""	""	0	""	""	""
+"MAR20167"	""	""	""	""	""	""	""	""	""	""	0	""	""	""
 "MAR20168"	""	""	""	""	""	""	""	""	""	""	0	""	""	""