Fixes #1929 hill transporter issue #1941
Conversation
src/Db/Dump/PKSimDB_dump.txt
Outdated
| @@ -82970,7 +82970,7 @@ INSERT INTO tab_rate_generic_molecules VALUES('LinksCommon','MetabolizationSpeci | |||
| INSERT INTO tab_rate_generic_molecules VALUES('LinksCommon','MetabolizationSpecific_Hill',372,'DRUG','C',0); | |||
| INSERT INTO tab_rate_generic_molecules VALUES('LinksCommon','MetabolizationSpecific_MM',370,'DRUG','CP',0); | |||
| INSERT INTO tab_rate_generic_molecules VALUES('LinksCommon','MetabolizationSpecific_MM',372,'DRUG','C',0); | |||
| INSERT INTO tab_rate_generic_molecules VALUES('LinksCommon','MucosaActiveInfluxFromLumen_Hill',368,'DRUG','TM',1); | |||
| INSERT INTO tab_rate_generic_molecules VALUES('LinksCommon','MucosaActiveInfluxFromLumen_Hill',366,'DRUG','TM',1); | |||
There was a problem hiding this comment.
This was Target|Transporter. Now Source|Transporter
It needs to be Target in fact because the transporter is not defined in Lumen but in the Mucosa compartment...that's right? @Yuri05 ?
There was a problem hiding this comment.
no, that's not right. Is probably a relic from V9 (where all GI processes were defined with source in Mucosa and Influx-transports had the negative rate to compensate this)
Must be defined Lumen=>Mucosa (same as e.g. MucosaActiveInfluxFromLumen_MM)
|
MucosaActiveInfluxFromLumen_MM is defined like this as well |
|
And setting path to be SOURCE/ doesn't work. So clearly the transporter is not defined here...we might have a little problem to check |
|
This is MM. As you can see, the Transporter concentration is taken from the Mucosa
|
|
@PavelBal Is it by design that the Lumen => Mucosa transporter observed the Transporter conc. in Mucosa?
|
|
@Yuri05 That's the same for
|
|
ok, after some thinking: that's correct. We place now the basolateral transporter ( |
Yes, it makes sense from the physiological point of view. |
No description provided.