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Liver zonation: wrong observer formula #2133

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Yuri05 opened this issue Mar 24, 2022 · 2 comments
Closed

Liver zonation: wrong observer formula #2133

Yuri05 opened this issue Mar 24, 2022 · 2 comments

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@Yuri05
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Yuri05 commented Mar 24, 2022

In the small molecules model, the formula of the liver tissue observer is wrong (+V_cell_prc is missing in the denominator).
In the default case (liver zonation deactivated) V_cell_prc=0 anyway, but if the liver zonation is activated, the observer value is wrong.

calculation_method formula_rate formula
Observer_PKSim_2Poren OBS_Tissue_liv (C_int_prp * V_int_prp + C_int_prc * V_int_prc + C_cell_prp * V_cell_prp + C_cell_prc * V_cell_prc + C_end_prp * V_end_prp + C_end_prc * V_end_prc)/(V_int_prp+V_int_prc+V_cell_prp+V_cell_prc+V_end_prp+V_end_prc)
Observer_PKSim_4Comp OBS_Tissue_liv (C_int_prp * V_int_prp + C_int_prc * V_int_prc + C_cell_prp * V_cell_prp + C_cell_prc * V_cell_prc)/(V_int_prp+V_int_prc+V_cell_prp)
@msevestre
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Hum this is already like this. Did you fix this already?

@msevestre
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Oh sorry. I thought you had written the correct one.

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