XBB.2.3 Lineage Tracker

[NkRMnZr]

XBB.2.3* Lineage Tracker

L455F

• XBB.2.3.2 > C7162T > G23417A(S:E619K) > G22927T(S:L455F), T22928C(S:F456L) [Query: C7162T, G23417A, G22927T, 1, Sep05] USA/AZ-ASU104733/2023|EPI_ISL_18225087|2023-08-24

F456L

• XBB.2.3 with ORF1a:L3588F (nsp6_L19F), S:F456L, N:K374Q, ORF1a:P1862S (nsp3_P1044S) and S:Q954Y (7 seqs, USA) sars-cov-2-variants/lineage-proposals#721 XBB.2.3 > T22615C > C25096T > A23800G > C2773T, G11029T(ORF1a:L3588F), T22928C(S:F456L), A29393C(N:K374Q) [Query: T22615C, T22928C, C24422T, 7, Sep11]
• GM.2 (XBB.2.3.6.2) > G29254T > G2513A(ORF1a:E750K), G11876A(ORF1a:V3871I), A12916G, C18248T(ORF1b:P1594L), T22930A(S:F456L) [Query: G22103C, T22930A, G29254T, 2, Sep19]
• GE.1 (XBB.2.3.10.1) > C601T > G2246A(ORF1a:G661S) > A16006G(ORF1b:I847V) > T508C, G1820A(ORF1a:G519S), T11296G(ORF1a:F3677L), T22928C(S:F456L) [Query: G1820A, T11296G, T22928C, 6, Sep22]
• XBB.2.3.19 mini-saltation with ORF1a:E940D (nsp3_E122D), S:R190S, S:F456L and S:C1248F (13 seqs, 5 countries) likely emerged in Oman sars-cov-2-variants/lineage-proposals#982 XBB.2.3.19 > C7303A > G3085T(ORF1a:E940D), G22132T(S:R190S), T22928C(S:F456L), G25305T(S:C1248F)

478X

• XBB.2.3 > C8266T > G8984A(ORF1a:D2907N) > A22996C(S:T478N) [Query: C8266T, G8984A, A22996C, 12, Sep29]
• XBB.2.3 > C11750T(ORF1a:L3829F) > T1303G, G2174A(ORF1a:E637K), C6330T(ORF1a:S2022L) > A6601G > T24796C > A8734G > G3353A(ORF1a:G1030S), C15774T > C22995T(S:T478I) [Query: G3353A, A8734G, C22995T, 3, Sep25]
• XBB.2.3.7 > G11042A(ORF1a:V3593I) > G1401A(ORF1a:G379E) > A7483G, C7488T(ORF1a:T2408I), C23320T, G27074A > A2386G, C22995G(S:T478R) [Query: G1401A, C7488T, C22995G, 5, Sep29]

Q613H

RBD Levels

• XBB.2.3 > C8266T > T14046G, C17976T, A22910G(S:N450D) [Query: G6536A, C8266T, A22910G, 34, Oct3]
• XBB.2.3 > C11750T(ORF1a:L3829F) > T1303G, G2174A(ORF1a:E637K), C6330T(ORF1a:S2022L) > A6601G > T24796C > A8734G > G3353A(ORF1a:G1030S), C15774T > T23042C(S:S494P) [Query: G3353A, A8734G, T23042C, 4, Sep18]
• HH.2 (XBB.2.3.2.2) > C683T, A23040T(S:Q493L) [Query: C683T, T20697C, A23040T, 28, Oct2]
• XBB.2.3.3 > C19884T > C3688T > T22195C(S:N211) > T10006C > C11442T(ORF1a:A3726V), A22893G(S:K444R) [Query: C3688T, T10006C, A22893G, 15, Oct3]

Known Potential Growth Boosters

Large Undesignated Cluster

Significant Local Prevalence

Others

• XBB.2.3.14 with ORF1b:T1050I (nsp13_T127I) (92 seqs, 12 countries) sars-cov-2-variants/lineage-proposals#235 XBB.2.3 > G3259T(ORF1a:Q998H) > C16616T(ORF1b:T1050I) [Query: C16616T, G3259T, C23123T, 101, Oct3]
• XBB.2.3.15 [ORF1a:I4308V (nsp10_I55V)] with ORF1a:M3669I (nsp6_M100I) and S:T323I (62 seqs, 4 countries) sars-cov-2-variants/lineage-proposals#722 XBB.2.3 > A13187G(ORF1a:I4308V) > G11272T(ORF1a:M3669I), C22530T(S:T323I)
• XBB.2.3 > C27389T > T24371A(S:S937T), A28174C(ORF8:K94T) [Query: G6536A, T24371A, C27389T, 41, Nov10]
• XBB.2.3.2 > C5628T(ORF1a:T1788M) > C24378T(S:S939F) [Query: C5628T, G6536A, C24378T, 31, Oct5]
• GJ.1.2 (XBB.2.3.2.1.2) > T16456C(ORF1b:S997P) > C1601T(ORF1a:L446F), C16575T, T17358C, T26498G > A10323G(ORF1a:K3353R), C22851T(S:T430I), C25482T [Query: C1601T, T17358C, C22851T, 7, Sep22]
• XBB.2.3.8 > G21586T(S:L8F) > T11158C, C16389T_Reversion, G23948C(S:D796H) [Query: G21586T, G23948C, C22995G, 11, Sep25]

Designated

• Designated as GJ.1.2.1 via cov-lineages/pango-designation@9326c3a , GJ.1.2 sublineage gained S:N450D ( 5 sequences South Korea , US, Singapore, France ) sars-cov-2-variants/lineage-proposals#446 GJ.1.2 (XBB.2.3.3.1.2) > A22910G(S:N450D) [Query: C7819G, G16795A, A22910G]
• XBB.2.3.11 with S:T470N (15 seqs, Singapore, Brunei) sars-cov-2-variants/lineage-proposals#93 Designated as GS.2 , follows XBB.2.3.11 > T16389C > C22971A(S:T470N), [Query: C4234T, G6536A, C22971A, -G22113T]

Inactive