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Inconsistent use of chemical roles (e.g. 'statin') between data sources leads to inconsistent results in the UI #28

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Genomewide opened this issue Oct 24, 2022 · 4 comments

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@Genomewide
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Results for Huntington's disease included multiple statin drugs. Fluvastatin has the predicate 'subclass_of' statins. The other statins did not have this predicate, but they are subclasses of statins.

@sierra-moxon sierra-moxon changed the title Data for all statins incomplete Inconsistent use of chemical roles (e.g. 'statin') between data sources leads to inconsistent results in the UI Nov 18, 2022
@Genomewide
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Why would FLUVASTATIN be a subclass of Statins and the remaining stating not be? Results include Rosuvastatin and Pravastatin. These two did not have 'subclass of'. The remaining statins were not there.

Link to what treats Huntington's Disease:
ui.transltr.io/results?q=3176389f-9e75-4e2e-9beb-bed32055de13

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@Genomewide
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Fluvastatin is in the ARAX results rank 21.
The remaining statins came from other ARAs.

@sstemann
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seems like i made a duplicate in #117

@sierra-moxon
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sierra-moxon commented Mar 24, 2023

From TAQA:
Aragorn/BTE - rule-based approach: if the chemical I'm looking for is a subclass of a family, then we can use that path in the rule. But if a ML approach by pathfinding, then if the black box approach finds one drug in one case and another drug in another case, it's not using statins, so no expectation that it would use statins
filling in of the paths is the second step to fill in the statin path, so it wouldn't do this

  • showing the full evidence graph might help? (e.g. single path is shown vs. full evidence graph). This is coming via the cytoscape view and will be showing the full path as a default (and the user will be able to interact with this), but this is "between" answers not "within" an answer.

Not intuitive from the UI, coming from ARAX. - pops out because this has "statin" in the name, which might not be that prevalent or unintuitive in most cases. Ok closing until next report/etc. :)

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