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Role of afferent-hair cell connectivity in determining spike train regularity (Holmes et al 2017)
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<html> <p>These files form the basis of simulations in </p><p>Holmes WR, Huwe JA, Williams B, Rowe MH, Peterson EH (2017) Models of utricular bouton afferents: role of afferent-hair cell connectivity in determining spike train regularity. J Neurophysiol 117:1969-1986 <a href="http://dx.doi.org/10.1152/jn.00895.2016">http://dx.doi.org/10.1152/jn.00895.2016<a/> </p><p>A number of these files, including some of the more clever algorithms, were adapted from work done by Jose Ambros-Ingerson for a different project. Morphology files for 4 vestibular bouton afferents, reconstructed from turtle, are included. </p><p>These scripts together with the simple GUI provided can be used directly to reproduce voltage traces in Figs 3-5 and data points in Figs 6-8 with only changing tstop, Poisson input rate and cell type. Tstop = 1000 ms here which is sufficient to illustrate runs that complete in a short amount of time. For the paper it was necessary to use tstop values of a few MINUTES in many cases in order to accumulate a large enough number of spikes to allow cv to be computed accurately. These simulations were run in batch mode and took days in some cases. <p/> Usage:<br/> ------<br/> Compile the mod files in the method appropriate for your platform (nrnivmodl on linux/unix, mknrndll on mswin/mac os x) and then run one of the following which generate the graphs shown by default. If you need more help consult the web page: <a href="https://senselab.med.yale.edu/ModelDB/NEURON_DwnldGuide">https://senselab.med.yale.edu/ModelDB/NEURON_DwnldGuide</a> <p/> Once you start the program select Tools->RunControl and then click on Init & Run.<br/> To get cv results click on Parameters -> Run to get cv data<br/> To get EPSPs for each synapse or Hair Cell activation click on Parameters -> Plot syn EPSPs (or Plot HC EPSPs)<br/> </p> <p>main-i6s-tnew.hoc <br/> -- One hair cell to one afferent connectivity, synaptic conductance </p><p> constant or scaled by bouton diameter. Runs produce data points for Figs 6A, 7A, 7C, 8 <p/><img src="./screenshot.png" alt="screenshot"> </p><p>main-i6s-hc.hoc <br/> --One hair cell to one or more afferents connectivity, synaptic conductance constant or scaled by bouton diameter. Runs produce traces in Fig 5 and data points for Figs 6B, 7B, 7C, 8 <p/><img src="./screenshot1.png" alt="screenshot"> </p><p>main-i6sBKSK-tnew.hoc <br/> --Same as main-i6s-tnew.hoc but with BK and SK conductances added. Runs produce traces in Fig. 3 and data points for Fig 8 <p/><img src="./screenshot2.png" alt="screenshot"> </p><p>main-i6sBKSK-hc.hoc <br/> --Same as main-i6s-hc.hoc except BK and SK conductances added. Runs produce traces in Fig 4 and data points for Figs. 6C and 8 <p/><img src="./screenshot.png" alt="screenshot"> </p> <p> <b>Changelog:</b><br> 2022-05: Updated MOD files to contain valid C++ and be compatible with the upcoming versions 8.2 and 9.0 of NEURON. </html>
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Role of afferent-hair cell connectivity in determining spike train regularity (Holmes et al 2017)
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