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Computational Neuroscience 3rd year CS course at the University of Bristol

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Computational Neuroscience

This is a 3rd year Computer Science and MSc unit. We will try to understand how the brain works from a computational point of view.

Coursework

See the coursework folder.

Staff

Important info

All live sessions will be hosted on Microsoft Teams. You should already have been added to the group "COMS30017: Computational Neuroscience (Teaching Unit) 2021/22 (TB-1, A)" You can download the MS Teams app free here, using your UoB email address.

Links

  • Unit forum subreddit: ask questions here. It includes questions from the previous year of the course, so some of the "admin" things may be different. But the course content will be similar!
  • Blackboard page: official University of Bristol landing page.

Overall structure

  • Weeks 1-7: Video lectures for the week released each Monday. Please watch when you can during the week. Each week will cover a different topic. Most weeks will also come with question sheets.
  • Weeks 2-8: Monday 12-1pm, live Q+A session with lecturer(s). Chance to ask questions to the lecturer about the previous week's material. Hosted on Microsoft Teams.
  • Weeks 2-7: Wednesday 11-12am, live bubble discussion seminars. Each bubble will be moderated by a TA or lecturer with discussion topics related to the lecture material. Hosted on Microsoft Teams.
  • Weeks 8-10: Coursework time, for those taking the 20-credit coursework version of the unit (COMS30015).
  • Week 11: Consolidation week. Catch up week for any further lecture material.
  • Week 12: Revision week. Preparation week for those students taking the 10-credit written exam version of unit (COMS30016 or COMSM0039).

Past exams

The 2021 January exams with solutions can be found here:

Previous years' exams can be found here (note they were a different format and had a different syllabus, so the above exam is more relevant): https://github.com/coms30127/exam_papers

Intro meeting with Q+A

video slides
Stream link pdf

Week 1 - Background on brains

[Lectures are from Cian, but please don't contact Cian as he has now left the university! Please ask at the lecturer-led Q&A, ask your TA, on the reddit or ask me ([email protected]).]

Lecture video slides
1. Why brains? 19:47 Stream link pdf
2. Brain anatomy. 21:37 Stream link pdf
3. Neuron anatomy: axons, dendrites, synapses. 12:02 Stream link pdf
4. Neuronal communication. 14:37 Stream link pdf
5. Measuring, recording and stimulating the brain. 19:54 Stream link pdf
Problem sheet --- pdf
Answers to problem sheet --- pdf
QA Stream link ---

Week 2 - CH - modelling neurons 1

Lectures:

You may notice that these were originally compiled for a PPN course. We need to go a bit further. (Hopefully, you'll know at least one of the topics below, depending on your course):

Problem sheet

Answers to problem sheet

Q&A

Link to last year's lectures/content

Week 3 - modelling neurons 2

Hodgkin Huxley, modelling neurons, analysing spiking data.

[Lectures are from Cian, but please don't contact Cian as he has now left the university! Please ask at the lecturer-led Q&A, ask your TA, on the reddit or ask me ([email protected]).]

Lecture video slides
1. Modelling neurons 26:29 [Stream link] [pdf]
2. Ion channels & dendritic integration. 23:24 [Stream link] [pdf]
3. Hodgkin-Huxley model. 33:51 [Stream link] [pdf]
4. Analysing spike data. 17:05 [Stream link] [pdf]
5. Neural decoding. 23:02 [Stream link] [pdf]
Problem Sheet --- [pdf]
Answers to problem sheet

|QA| [Stream link]

Previous notes from CH:

Week 4: Synapses and synaptic plasticity

Lecture video slides
1. What is a synapse? 26:29 [Stream link] [pdf]
2. Computational modelling of a synapse 25:31 [Stream link] [pdf]
3. Synaptic plasticity 11:02 [Stream link] [pdf]
4. Short-term plasticity 14:38 [Stream link] [pdf]
5. Long-term plasticity 33:07 [Stream link] [pdf]
Video of simulation of synaptic activity 3:00 [Stream link]
Problem Sheet --- [pdf]
Answers to problem sheet

Week 5: Hippocampus + Hopfield networks

Lecture video slides
1. The Hippocampus and long-term memory 16:32 [Stream link] [pdf]
2. The Hippocampus and spatial navigation 10:37 [Stream link] [pdf]
3. Pattern Separation 20:43 [Stream link] [pdf]
4. Hopfield networks (discrete attractors) 12:35 [Stream link] [pdf]
5. Continuous attractors and navigation 12:28 [Stream link] [pdf]
Problem sheet --- [pdf]
Answers --- [pdf]
Q&A [Stream link] ---

Week 6: Visual system + rate coding

Lecture video slides
1. Firing rates and receptive fields 16:51 [Stream link] [pdf]
2. The visual pathway 15:17 [Stream link] [pdf]
3. Retina 7:08 [Stream link] [pdf]
4. V1 and the cortical microcircuit 15:46 [Stream link] [pdf]
5. Topographic maps and sparse coding 20:43 [Stream link] [pdf]
Problem sheet --- [pdf]
Answers --- [pdf]
Q&A [Stream link] --

Week 7: Cerebellum/basal ganglia, perceptrons, Rescorla-Wagner, blocking.

Lecture video slides
1. Supervised learning using the delta rule 12:00 [Stream link] [pdf]
2. Cerebellar anatomy, function and microstructure 16:27 [Stream link] [pdf]
3. Classical conditioning 19:32 [Stream link] [pdf]
4. Temporal difference learning and dopamine 12:17 [Stream link] [pdf]
Problem sheet --- [pdf]
Answers --- [pdf]

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