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Fix #78
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veghp committed Nov 7, 2024
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Expand Up @@ -26,9 +26,17 @@ composed to, for instance, codon-optimize genes, meet the constraints of a
commercial DNA provider, avoid homologies between sequences, tune GC content,
or all of this at once! Users can also define their own specifications using
Python, making the library suitable for a large range of automated sequence
design applications, and complex custom design projects.
design applications, and complex custom design projects. A specification can be
either a hard constraint, which must be satisfied in the final sequence, or an
optimization objective, whose score must be maximized.
For more information, please see the publication.


Citation
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DNA Chisel, a versatile sequence optimizer, *Valentin Zulkower, Susan Rosser.* `Bioinformatics <https://academic.oup.com/bioinformatics/article/36/16/4508/5869515>`_ (2020) 36, 16, 4508–4509


Usage
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