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Fix Isensee_JCB2018 #138

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merged 11 commits into from
Oct 16, 2021
Merged

Fix Isensee_JCB2018 #138

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5005125
simplify formulation
FFroehlich Oct 13, 2021
04e2971
add parameter priors, fixes #137
FFroehlich Oct 13, 2021
2806465
fixup conditions
FFroehlich Oct 13, 2021
4a14b7f
remove uninformative priors
FFroehlich Oct 13, 2021
69d1fed
reexport conditions/measurements from d2d
FFroehlich Oct 14, 2021
05cbce2
fixup
FFroehlich Oct 14, 2021
ef85dec
fix model
FFroehlich Oct 14, 2021
80d237a
fixup
FFroehlich Oct 14, 2021
88f2521
fix empty rows
FFroehlich Oct 16, 2021
0057cfd
remove index from measurement table
FFroehlich Oct 16, 2021
f2ad4c7
update simulated data
FFroehlich Oct 16, 2021
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246 changes: 124 additions & 122 deletions Benchmark-Models/Isensee_JCB2018/experimentalCondition_Isensee_JCB2018.tsv
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1,374 changes: 687 additions & 687 deletions Benchmark-Models/Isensee_JCB2018/measurementData_Isensee_JCB2018.tsv
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24 changes: 4 additions & 20 deletions Benchmark-Models/Isensee_JCB2018/model_Isensee_JCB2018.xml
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Original file line number Diff line number Diff line change
Expand Up @@ -252,11 +252,7 @@
<apply>
<minus/>
<csymbol encoding="text" definitionURL="http://www.sbml.org/sbml/symbols/time"> time </csymbol>
<apply>
<minus/>
<cn type="integer"> 60 </cn>
<ci> Rp8_Br_cAMPS_pAB_incubation_time </ci>
</apply>
<ci> Rp8_Br_cAMPS_pAB_incubation_time </ci>
</apply>
<cn type="integer"> 0 </cn>
</apply>
Expand All @@ -281,11 +277,7 @@
<apply>
<minus/>
<csymbol encoding="text" definitionURL="http://www.sbml.org/sbml/symbols/time"> time </csymbol>
<apply>
<minus/>
<cn type="integer"> 60 </cn>
<ci> Rp8_pCPT_cAMPS_pAB_incubation_time </ci>
</apply>
<ci> Rp8_pCPT_cAMPS_pAB_incubation_time </ci>
</apply>
<cn type="integer"> 0 </cn>
</apply>
Expand All @@ -310,11 +302,7 @@
<apply>
<minus/>
<csymbol encoding="text" definitionURL="http://www.sbml.org/sbml/symbols/time"> time </csymbol>
<apply>
<minus/>
<cn type="integer"> 60 </cn>
<ci> Rp_cAMPS_pAB_incubation_time </ci>
</apply>
<ci> Rp_cAMPS_pAB_incubation_time </ci>
</apply>
<cn type="integer"> 0 </cn>
</apply>
Expand Down Expand Up @@ -364,11 +352,7 @@
<apply>
<minus/>
<csymbol encoding="text" definitionURL="http://www.sbml.org/sbml/symbols/time"> time </csymbol>
<apply>
<minus/>
<cn type="integer"> 60 </cn>
<ci> fourABnOH_incubation_time </ci>
</apply>
<ci> fourABnOH_incubation_time </ci>
</apply>
<cn type="integer"> 0 </cn>
</apply>
Expand Down
9 changes: 3 additions & 6 deletions Benchmark-Models/Isensee_JCB2018/observables_Isensee_JCB2018.tsv
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Original file line number Diff line number Diff line change
@@ -1,7 +1,4 @@
observableId observableName observableFormula noiseFormula observableTransformation noiseDistribution
pRII_Microscopy_1 observableParameter1_pRII_Microscopy_1 * (observableParameter3_pRII_Microscopy_1 + observableParameter2_pRII_Microscopy_1 * (2 * RIIp_2 + 2 * RIIp_cAMP_2 + 2 * RIIp_Sp8_Br_cAMPS_2 + 2 * observableParameter4_pRII_Microscopy_1 * (RIIp_C_2 + RIIp_Rp_cAMPS_C_2 + RIIp_Rp8_Br_cAMPS_C_2 + RIIp_Rp8_pCPT_cAMPS_C_2) + 2 * (RIIp_cAMP_C_2 + RIIp_Sp8_Br_cAMPS_C_2) * (observableParameter4_pRII_Microscopy_1 - observableParameter5_pRII_Microscopy_1 * (observableParameter4_pRII_Microscopy_1 - 1)))) noiseParameter1_pRII_Microscopy_1 * noiseParameter2_pRII_Microscopy_1 * noiseParameter3_pRII_Microscopy_1 lin normal
pRII_Microscopy_3 observableParameter1_pRII_Microscopy_3 * (observableParameter3_pRII_Microscopy_3 + observableParameter2_pRII_Microscopy_3 * (2 * RIIp_2 + 2 * RIIp_cAMP_2 + 2 * RIIp_Sp8_Br_cAMPS_2 + 2 * observableParameter4_pRII_Microscopy_3 * (RIIp_C_2 + RIIp_Rp_cAMPS_C_2 + RIIp_Rp8_Br_cAMPS_C_2 + RIIp_Rp8_pCPT_cAMPS_C_2) + 2 * (RIIp_cAMP_C_2 + RIIp_Sp8_Br_cAMPS_C_2) * (observableParameter4_pRII_Microscopy_3 - observableParameter5_pRII_Microscopy_3 * (observableParameter4_pRII_Microscopy_3 - 1)))) noiseParameter1_pRII_Microscopy_3 * noiseParameter2_pRII_Microscopy_3 * noiseParameter3_pRII_Microscopy_3 lin normal
pRII_Microscopy_5 observableParameter1_pRII_Microscopy_5 * (observableParameter3_pRII_Microscopy_5 + observableParameter2_pRII_Microscopy_5 * (2 * RIIp_2 + 2 * RIIp_cAMP_2 + 2 * RIIp_Sp8_Br_cAMPS_2 + 2 * observableParameter4_pRII_Microscopy_5 * (RIIp_C_2 + RIIp_Rp_cAMPS_C_2 + RIIp_Rp8_Br_cAMPS_C_2 + RIIp_Rp8_pCPT_cAMPS_C_2) + 2 * (RIIp_cAMP_C_2 + RIIp_Sp8_Br_cAMPS_C_2) * (observableParameter4_pRII_Microscopy_5 - observableParameter5_pRII_Microscopy_5 * (observableParameter4_pRII_Microscopy_5 - 1)))) noiseParameter1_pRII_Microscopy_5 * noiseParameter2_pRII_Microscopy_5 * noiseParameter3_pRII_Microscopy_5 lin normal
pRII_Microscopy_7 observableParameter1_pRII_Microscopy_7 * (observableParameter3_pRII_Microscopy_7 + observableParameter2_pRII_Microscopy_7 * (2 * RIIp_2 + 2 * RIIp_cAMP_2 + 2 * RIIp_Sp8_Br_cAMPS_2 + 2 * observableParameter4_pRII_Microscopy_7 * (RIIp_C_2 + RIIp_Rp_cAMPS_C_2 + RIIp_Rp8_Br_cAMPS_C_2 + RIIp_Rp8_pCPT_cAMPS_C_2) + 2 * (RIIp_cAMP_C_2 + RIIp_Sp8_Br_cAMPS_C_2) * (observableParameter4_pRII_Microscopy_7 - observableParameter5_pRII_Microscopy_7 * (observableParameter4_pRII_Microscopy_7 - 1)))) noiseParameter1_pRII_Microscopy_7 * noiseParameter2_pRII_Microscopy_7 * noiseParameter3_pRII_Microscopy_7 lin normal
pRII_Western_1 observableParameter1_pRII_Western_1 * (2 * RIIp_2 + 2 * RIIp_C_2 + 2 * RIIp_cAMP_2 + 2 * RIIp_cAMP_C_2 + 2 * RIIp_Rp_cAMPS_C_2 + 2 * RIIp_Sp8_Br_cAMPS_2 + 2 * RIIp_Rp8_Br_cAMPS_C_2 + 2 * RIIp_Sp8_Br_cAMPS_C_2 + 2 * RIIp_Rp8_pCPT_cAMPS_C_2) noiseParameter1_pRII_Western_1 * noiseParameter2_pRII_Western_1 lin normal
Calpha_Microscopy_1 observableParameter2_Calpha_Microscopy_1 + observableParameter1_Calpha_Microscopy_1 * (2 * Csub + 2 * Csub_H89 + 2 * observableParameter3_Calpha_Microscopy_1 * (RIIp_C_2 + RIIp_Rp_cAMPS_C_2 + RIIp_Rp8_Br_cAMPS_C_2 + RIIp_Rp8_pCPT_cAMPS_C_2) + 2 * (RIIp_cAMP_C_2 + RIIp_Sp8_Br_cAMPS_C_2) * (observableParameter3_Calpha_Microscopy_1 - observableParameter4_Calpha_Microscopy_1 * (observableParameter3_Calpha_Microscopy_1 - 1))) noiseParameter1_Calpha_Microscopy_1 * noiseParameter2_Calpha_Microscopy_1 lin normal
pRII_Microscopy observableParameter1_pRII_Microscopy * (b_pRII_global + s_pRII_global * (2 * RIIp_2 + 2 * RIIp_cAMP_2 + 2 * RIIp_Sp8_Br_cAMPS_2 + 2 * rel_open * (RIIp_C_2 + RIIp_Rp_cAMPS_C_2 + RIIp_Rp8_Br_cAMPS_C_2 + RIIp_Rp8_pCPT_cAMPS_C_2) + 2 * (RIIp_cAMP_C_2 + RIIp_Sp8_Br_cAMPS_C_2) * (rel_open - xi_rel_open * (rel_open - 1)))) noiseParameter1_pRII_Microscopy * s_pRII_global * rho_pRII_Microscopy lin normal
pRII_Western s_pRII_Western * (2 * RIIp_2 + 2 * RIIp_C_2 + 2 * RIIp_cAMP_2 + 2 * RIIp_cAMP_C_2 + 2 * RIIp_Rp_cAMPS_C_2 + 2 * RIIp_Sp8_Br_cAMPS_2 + 2 * RIIp_Rp8_Br_cAMPS_C_2 + 2 * RIIp_Sp8_Br_cAMPS_C_2 + 2 * RIIp_Rp8_pCPT_cAMPS_C_2) s_pRII_Western * rho_pRII_Western lin normal
Calpha_Microscopy observableParameter1_Calpha_Microscopy * (b_Calpha_global + s_Calpha_global * (2 * Csub + 2 * Csub_H89 + 2 * rel_open * (RIIp_C_2 + RIIp_Rp_cAMPS_C_2 + RIIp_Rp8_Br_cAMPS_C_2 + RIIp_Rp8_pCPT_cAMPS_C_2) + 2 * (RIIp_cAMP_C_2 + RIIp_Sp8_Br_cAMPS_C_2) * (rel_open - xi_rel_open * (rel_open - 1)))) s_Calpha_global * rho_Calpha_Microscopy lin normal
121 changes: 61 additions & 60 deletions Benchmark-Models/Isensee_JCB2018/parameters_Isensee_JCB2018.tsv
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Original file line number Diff line number Diff line change
@@ -1,60 +1,61 @@
parameterId parameterName parameterScale lowerBound upperBound nominalValue estimate
AC_total AC_{total} log10 1E-05 1000 1 0
KD_Fsk KD_{Fsk} log10 1E-05 1000 14.2805171742694 1
KD_H89 KD_{H89} log10 1E-05 1000 0.048074027232332 1
KD_IBMX KD_{IBMX} log10 1E-05 1000 11.960772655864 1
KD_PDE_Csub KD_{PDE,Csub} lin -5 3 0 0
KD_cAMP KD_{cAMP} log10 1E-05 1000 2.85002019924967 1
PDE_total PDE_{total} log10 1E-05 1000 1 0
RII2_total RII2_{total} log10 1E-05 1000 1 0
b_Calpha_global b_{Calpha,global} log10 0.001 1000 101.662732662228 1
b_pRII_global b_{pRII,global} log10 0.001 1000 99.7184671220999 1
kdeg_cAMP kdeg_{cAMP} log10 1E-05 1000 1.00000660182181E-05 1
kdeg_cAMP_free kdeg_{cAMP,free} log10 1E-05 1000 7.38363782272545 1
kdp_AC kdp_{AC} lin -5 3 0 0
kf_Fsk kf_{Fsk} log10 1E-05 1000 999.999958296064 1
kf_H89 kf_{H89} log10 1E-05 1000 0.000742716621349 1
kf_PDE_Csub kf_{PDE,Csub} lin -5 3 0 0
kf_RII_2__RII_C_2 kf_{RII_2,RII_C_2} log10 1E-05 100000 1.26446106685121 1
kf_RII_C_2__RII_2 kf_{RII_C_2,RII_2} log10 1E-05 1000 0.018746739843535 1
kf_RII_C_2__RIIp_C_2 kf_{RII_C_2,RIIp_C_2} log10 1E-05 1000 0.022767932816744 1
kf_RIIp_2__RII_2 kf_{RIIp_2,RII_2} log10 1E-05 1000 0.03230162532087 1
kf_RIIp_C_2__RII_C_2 kf_{RIIp_C_2,RII_C_2} log10 1E-05 1000 0.025703919542656 1
kf_RIIp_cAMP_C_2__RIIp_2 kf_{RIIp_cAMP_C_2,RIIp_2} log10 1E-05 1000 0.105283748414996 1
kf_cAMP kf_{cAMP} log10 1E-05 1000 0.501542412469253 1
ki_IBMX ki_{IBMX} log10 1E-05 1000 999.99999999947 1
ki_Rp8_Br_cAMPS_pAB ki_{Rp8,Br,cAMPS,pAB} log10 1E-05 1000 6.44560005260773 1
ki_Rp8_pCPT_cAMPS_pAB ki_{Rp8,pCPT,cAMPS,pAB} log10 1E-05 1000 9.3898794585472 1
ki_Rp_cAMPS_pAB ki_{Rp,cAMPS,pAB} log10 1E-05 1000 0.016320587381729 1
ki_Sp8_Br_cAMPS_AM ki_{Sp8,Br,cAMPS,AM} log10 1E-05 1000 0.131657936881857 1
kp_AC kp_{AC} lin -5 3 0 0
ks_AC_cAMP ks_{AC,cAMP} log10 1E-05 1000 0.423150583624568 1
rel_open rel_{open} log10 1E-05 1 0.232684484588385 1
s_Calpha_global s_{Calpha,global} log10 1000 3162.27766016838 1758.15501421399 1
s_pRII_JI09_150302_Drg345_343_CycNuc s_{pRII,JI09,150302,Drg345,343,CycNuc} log10 0.001 1000 1.1029976101468 1
s_pRII_JI09_150330_Drg350_348_CycNuc s_{pRII,JI09,150330,Drg350,348,CycNuc} log10 0.001 1000 0.9067516915655 1
s_pRII_JI09_150330_Drg353_351_CycNuc s_{pRII,JI09,150330,Drg353,351,CycNuc} log10 0.001 1000 0.934506349283962 1
s_pRII_JI09_151102_Drg421_418_Age s_{pRII,JI09,151102,Drg421,418,Age} log10 0.001 1000 1.06693094665605 1
s_pRII_Western s_{pRII,Western} log10 0.1 100000 1.14849828435972 1
s_pRII_global s_{pRII,global} log10 1000 3162.27766016838 2206.77137565008 1
rho_Calpha_Microscopy \rho_{Calpha,Microscopy} log10 1E-05 1000 0.049753182233122 1
rho_pRII_Microscopy \rho_{pRII,Microscopy} log10 1E-05 1000 0.040685236621013 1
rho_pRII_Western \rho_{pRII,Western} log10 1E-05 1000 0.099334983213923 1
xi_AC_cAMP_Fsk \xi_{AC_{cAMP,Fsk} log10 1E-05 1000 642.370332155571 1
xi_KD_Rp8_Br_cAMPS \xi_{KD,Rp8,Br,cAMPS} log10 1E-05 100000 0.039962383560766 1
xi_KD_Rp8_pCPT_cAMPS \xi_{KD,Rp8,pCPT,cAMPS} log10 1E-05 100000 0.194212924719718 1
xi_KD_Rp_cAMPS \xi_{KD,Rp,cAMPS} log10 1E-05 100000 0.163047074866588 1
xi_KD_Sp8_Br_cAMPS \xi_{KD,Sp8,Br,cAMPS} log10 1E-05 100000 0.22324026500667 1
xi_b_Rp8_Br_cAMPS \xi_{b,Rp8,Br,cAMPS} log10 1E-05 100000 0.040559301141753 1
xi_b_Rp8_pCPT_cAMPS \xi_{b,Rp8,pCPT,cAMPS} log10 1E-05 100000 0.026684466293791 1
xi_b_Rp_cAMPS \xi_{b,Rp,cAMPS} log10 1E-05 100000 0.603928050380137 1
xi_b_Sp8_Br_cAMPS \xi_{b,Sp8,Br,cAMPS} log10 1E-05 100000 21.6150210996832 1
xi_i_Rp8_Br_cAMPS_pAB \xi_{i,Rp8,Br,cAMPS,pAB} log10 1E-05 1 1 0
xi_i_Rp8_pCPT_cAMPS_pAB \xi_{i,Rp8,pCPT,cAMPS,pAB} log10 1E-05 1 1 0
xi_i_Rp_cAMPS_pAB \xi_{i,Rp,cAMPS,pAB} log10 1E-05 1 1 0
xi_i_Sp8_Br_cAMPS_AM \xi_{i,Sp8,Br,cAMPS,AM} log10 1E-05 1 1 0
xi_kf_RII_2__RII_C_2 \xi_{kf_RII_2,RII_C_2} log10 1E-05 1 0.01893099823943 1
xi_kf_RII_C_2__RII_2 \xi_{kf_RII_C_2,RII_2} log10 1E-05 100000 0.810991675177056 1
xi_pAC \xi_{pAC} log10 0.001 1 1 0
xi_pPDE \xi_{pPDE} log10 1 1000 1 0
xi_rel_open \xi_{rel,open} log10 1E-05 1 0.749424660751357 1
parameterId parameterName parameterScale lowerBound upperBound nominalValue estimate objectivePrior objectivePriorParameters
AC_total AC_{total} log10 1E-05 1000 1 0
KD_Fsk KD_{Fsk} log10 1E-05 1000 14.2805171742694 1 parameterScaleNormal 0.845098;0.2
KD_H89 KD_{H89} log10 1E-05 1000 0.048074027232332 1 parameterScaleNormal -1.31876;0.2
KD_IBMX KD_{IBMX} log10 1E-05 1000 11.960772655864 1 parameterScaleNormal 1.0;0.2
KD_PDE_Csub KD_{PDE,Csub} lin -5 3 0 0
KD_cAMP KD_{cAMP} log10 1E-05 1000 2.85002019924967 1 parameterScaleNormal 0.462398;0.2
PDE_total PDE_{total} log10 1E-05 1000 1 0
RII2_total RII2_{total} log10 1E-05 1000 1 0
b_Calpha_global b_{Calpha,global} log10 0.001 1000 101.662732662228 1 parameterScaleNormal 2;0.1
b_pRII_global b_{pRII,global} log10 0.001 1000 99.7184671220999 1 parameterScaleNormal 2;0.1
kdeg_cAMP kdeg_{cAMP} log10 1E-05 1000 1.00000660182181E-05 1
kdeg_cAMP_free kdeg_{cAMP,free} log10 1E-05 1000 7.38363782272545 1
kdp_AC kdp_{AC} lin -5 3 0 0
kf_Fsk kf_{Fsk} log10 1E-05 1000 999.999958296064 1
kf_H89 kf_{H89} log10 1E-05 1000 0.000742716621349 1
kf_PDE_Csub kf_{PDE,Csub} lin -5 3 0 0
kf_RII_2__RII_C_2 kf_{RII_2,RII_C_2} log10 1E-05 100000 1.26446106685121 1
kf_RII_C_2__RII_2 kf_{RII_C_2,RII_2} log10 1E-05 1000 0.018746739843535 1
kf_RII_C_2__RIIp_C_2 kf_{RII_C_2,RIIp_C_2} log10 1E-05 1000 0.022767932816744 1
kf_RIIp_2__RII_2 kf_{RIIp_2,RII_2} log10 1E-05 1000 0.03230162532087 1
kf_RIIp_C_2__RII_C_2 kf_{RIIp_C_2,RII_C_2} log10 1E-05 1000 0.025703919542656 1
kf_RIIp_cAMP_C_2__RIIp_2 kf_{RIIp_cAMP_C_2,RIIp_2} log10 1E-05 1000 0.105283748414996 1
kf_cAMP kf_{cAMP} log10 1E-05 1000 0.501542412469253 1
ki_IBMX ki_{IBMX} log10 1E-05 1000 999.99999999947 1
ki_Rp8_Br_cAMPS_pAB ki_{Rp8,Br,cAMPS,pAB} log10 1E-05 1000 6.44560005260773 1
ki_Rp8_pCPT_cAMPS_pAB ki_{Rp8,pCPT,cAMPS,pAB} log10 1E-05 1000 9.3898794585472 1
ki_Rp_cAMPS_pAB ki_{Rp,cAMPS,pAB} log10 1E-05 1000 0.016320587381729 1
ki_Sp8_Br_cAMPS_AM ki_{Sp8,Br,cAMPS,AM} log10 1E-05 1000 0.131657936881857 1
kp_AC kp_{AC} lin -5 3 0 0
ks_AC_cAMP ks_{AC,cAMP} log10 1E-05 1000 0.423150583624568 1
rel_open rel_{open} log10 1E-05 1 0.232684484588385 1
s_Calpha_JI09_160201_Drg453_452_CycNuc s_{Calpha,JI09,160201,Drg453,452,CycNuc} log10 1E-5 1000 1 0
s_Calpha_global s_{Calpha,global} log10 1000 3162.27766016838 1758.15501421399 1
s_pRII_JI09_150302_Drg345_343_CycNuc s_{pRII,JI09,150302,Drg345,343,CycNuc} log10 0.001 1000 1.1029976101468 1 parameterScaleNormal 0;0.1
s_pRII_JI09_150330_Drg350_348_CycNuc s_{pRII,JI09,150330,Drg350,348,CycNuc} log10 0.001 1000 0.9067516915655 1 parameterScaleNormal 0;0.1
s_pRII_JI09_150330_Drg353_351_CycNuc s_{pRII,JI09,150330,Drg353,351,CycNuc} log10 0.001 1000 0.934506349283962 1 parameterScaleNormal 0;0.1
s_pRII_JI09_151102_Drg421_418_Age s_{pRII,JI09,151102,Drg421,418,Age} log10 0.001 1000 1.06693094665605 1 parameterScaleNormal 0;0.1
s_pRII_Western s_{pRII,Western} log10 0.1 100000 1.14849828435972 1
s_pRII_global s_{pRII,global} log10 1000 3162.27766016838 2206.77137565008 1
rho_Calpha_Microscopy \rho_{Calpha,Microscopy} log10 1E-05 1000 0.049753182233122 1
rho_pRII_Microscopy \rho_{pRII,Microscopy} log10 1E-05 1000 0.040685236621013 1
rho_pRII_Western \rho_{pRII,Western} log10 1E-05 1000 0.099334983213923 1
xi_AC_cAMP_Fsk \xi_{AC_{cAMP,Fsk} log10 1E-05 1000 642.370332155571 1
xi_KD_Rp8_Br_cAMPS \xi_{KD,Rp8,Br,cAMPS} log10 1E-05 100000 0.039962383560766 1 parameterScaleNormal 0;3
xi_KD_Rp8_pCPT_cAMPS \xi_{KD,Rp8,pCPT,cAMPS} log10 1E-05 100000 0.194212924719718 1 parameterScaleNormal 0;3
xi_KD_Rp_cAMPS \xi_{KD,Rp,cAMPS} log10 1E-05 100000 0.163047074866588 1 parameterScaleNormal 0;3
xi_KD_Sp8_Br_cAMPS \xi_{KD,Sp8,Br,cAMPS} log10 1E-05 100000 0.22324026500667 1 parameterScaleNormal 0;3
xi_b_Rp8_Br_cAMPS \xi_{b,Rp8,Br,cAMPS} log10 1E-05 100000 0.040559301141753 1 parameterScaleNormal 0;3
xi_b_Rp8_pCPT_cAMPS \xi_{b,Rp8,pCPT,cAMPS} log10 1E-05 100000 0.026684466293791 1 parameterScaleNormal 0;3
xi_b_Rp_cAMPS \xi_{b,Rp,cAMPS} log10 1E-05 100000 0.603928050380137 1 parameterScaleNormal 0;3
xi_b_Sp8_Br_cAMPS \xi_{b,Sp8,Br,cAMPS} log10 1E-05 100000 21.6150210996832 1 parameterScaleNormal 0;3
xi_i_Rp8_Br_cAMPS_pAB \xi_{i,Rp8,Br,cAMPS,pAB} log10 1E-05 1 1 0 parameterScaleNormal 0;3
xi_i_Rp8_pCPT_cAMPS_pAB \xi_{i,Rp8,pCPT,cAMPS,pAB} log10 1E-05 1 1 0 parameterScaleNormal 0;3
xi_i_Rp_cAMPS_pAB \xi_{i,Rp,cAMPS,pAB} log10 1E-05 1 1 0 parameterScaleNormal 0;3
xi_i_Sp8_Br_cAMPS_AM \xi_{i,Sp8,Br,cAMPS,AM} log10 1E-05 1 1 0 parameterScaleNormal 0;3
xi_kf_RII_2__RII_C_2 \xi_{kf_RII_2,RII_C_2} log10 1E-05 1 0.01893099823943 1 parameterScaleNormal -1.74244;0.1
xi_kf_RII_C_2__RII_2 \xi_{kf_RII_C_2,RII_2} log10 1E-05 100000 0.810991675177056 1 parameterScaleNormal -0.0621479;0.1
xi_pAC \xi_{pAC} log10 0.001 1 1 0 parameterScaleNormal 0;3
xi_pPDE \xi_{pPDE} log10 1 1000 1 0 parameterScaleNormal 0.39794;3
xi_rel_open \xi_{rel,open} log10 1E-05 1 0.749424660751357 1
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