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## Overview
**anglemania** is a new approach to the integration of scRNA-seq (and, potentially, others sc-omics) from **similar** biological entities.
The novelty, as well as the cornerstone, of the proposed approach, is to use the conservation of [angles](https://arxiv.org/abs/1306.0256) between gene pairs across an assembly of datasets to be integrated.
anglemania extracts genes from gene pairs that exhibit invariant and biologically meaningful relationships across different experiments. Those genes can subsequently be used as the basis for integration algorithms such as [[Seurat CCA integration](https://satijalab.org/seurat/reference/ccaintegration)], [[SCVI](https://docs.scvi-tools.org/en/stable/api/reference/scvi.model.SCVI.html)] and others.
Checkout our [[website](https://bioinformatics.mdc-berlin.de/anglemania)].
anglemania extracts genes from gene pairs that exhibit invariant and biologically meaningful relationships across different experiments. Those genes can subsequently be used as the basis for integration algorithms such as [Seurat CCA integration](https://satijalab.org/seurat/reference/ccaintegration), [SCVI](https://docs.scvi-tools.org/en/stable/api/reference/scvi.model.SCVI.html) and others.
Checkout our [website](https://bioinformatics.mdc-berlin.de/anglemania).

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| Github | [![Github](https://github.com/BIMSBbioinfo/anglemania/actions/workflows/R-CMD-check.yaml/badge.svg)](https://github.com/BIMSBbioinfo/anglemania/actions/workflows/R-CMD-check.yaml) |
| Bioc Release | [![Bioc Release](https://bioconductor.org/shields/years-in-bioc/anglemania.svg)](https://bioconductor.org/packages/anglemania)
| Coverage | [![Codecov test coverage](https://codecov.io/gh/BIMSBbioinfo/anglemania/graph/badge.svg)](https://app.codecov.io/gh/BIMSBbioinfo/anglemania)




## Installation

You can install **anglemania** from Bioconductor using the following commands:
**once available on Bioconductor:**

```r
# Install BiocManager if you haven't already
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install.packages("devtools")

# Install from GitHub
devtools::install_github("BIMSBbioinfo/anglemania/")
devtools::install_github("BIMSBbioinfo/anglemania")
```


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