diff --git a/nox/sessions.py b/nox/sessions.py
index b51161a6..a50d19b4 100644
--- a/nox/sessions.py
+++ b/nox/sessions.py
@@ -22,6 +22,7 @@
 import pathlib
 import re
 import subprocess
+import shutil
 import sys
 import unicodedata
 from collections.abc import (
@@ -561,6 +562,7 @@ def _run(
             self.virtualenv.venv_backend == "uv"
             and args[0] == "uv"
             and nox.virtualenv.UV != "uv"
+            and shutil.which("uv", path=self.bin) is None
         ):
             args = (nox.virtualenv.UV, *args[1:])