diff --git a/Snakefile b/Snakefile
index e088368..c99453f 100644
--- a/Snakefile
+++ b/Snakefile
@@ -88,6 +88,7 @@ rule all:
         f"work/download/genes/clingen/{DV.clingen_gene}/clingen.csv",
         f"work/download/genes/rcnv/2022/Collins_rCNV_2022.dosage_sensitivity_scores.tsv.gz",
         f"work/download/genes/orphapacket/{DV.orphapacket}/orphapacket.tar.gz",
+        "work/download/genes/alphamissense/1/AlphaMissense_gene_hg38.tsv.gz",
         f"work/genes/dbnsfp/{DV.dbnsfp}/genes.tsv.gz",
         f"work/genes/ensembl/{DV.ensembl}/ensembl_xlink.tsv",
         f"work/genes/enst_ensg/grch37/{DV.ensembl_37}/enst_ensg.tsv",
@@ -323,6 +324,7 @@ rule all:
 # Misc rules.
 include: "rules/work/misc/hpo.smk"
 # Gene-related rules.
+include: "rules/work/genes/alphamissense.smk"
 include: "rules/work/genes/dbnsfp.smk"
 include: "rules/work/genes/clingen.smk"
 include: "rules/work/genes/ensembl.smk"
@@ -344,6 +346,7 @@ include: "rules/work/annos/features/refseq.smk"
 include: "rules/work/annos/features/tads.smk"
 include: "rules/work/annos/features/ucsc.smk"
 # Sequence variants and annotations.
+include: "rules/work/annos/seqvars/alphamissense.smk"
 include: "rules/work/annos/seqvars/cadd.smk"
 include: "rules/work/annos/seqvars/dbnsfp.smk"
 include: "rules/work/annos/seqvars/dbscsnv.smk"
diff --git a/environment.yml b/environment.yml
index 058ad0a..f44f1af 100644
--- a/environment.yml
+++ b/environment.yml
@@ -1,4 +1,3 @@
-name: varfish-db-downloader
 channels:
   - bioconda
   - conda-forge
diff --git a/excerpt-data/31296ac84aa243ce/AlphaMissense_hg19.tsv.gz b/excerpt-data/31296ac84aa243ce/AlphaMissense_hg19.tsv.gz
new file mode 100644
index 0000000..9a29994
--- /dev/null
+++ b/excerpt-data/31296ac84aa243ce/AlphaMissense_hg19.tsv.gz
@@ -0,0 +1,3 @@
+version https://git-lfs.github.com/spec/v1
+oid sha256:59e4ae2448406ca7d201aa2bb7508bea90bf154a1c39a59ed7df9e60aeab5799
+size 1126
diff --git a/excerpt-data/31296ac84aa243ce/url.txt b/excerpt-data/31296ac84aa243ce/url.txt
new file mode 100644
index 0000000..6d11716
--- /dev/null
+++ b/excerpt-data/31296ac84aa243ce/url.txt
@@ -0,0 +1,3 @@
+version https://git-lfs.github.com/spec/v1
+oid sha256:b304f0ef4fecce99a54b68348ff334923254fd23d27261bf356222b81997beb7
+size 74
diff --git a/excerpt-data/521f5677c9d5d6b3/AlphaMissense_gene_hg38.tsv.gz b/excerpt-data/521f5677c9d5d6b3/AlphaMissense_gene_hg38.tsv.gz
new file mode 100644
index 0000000..5bb7a81
--- /dev/null
+++ b/excerpt-data/521f5677c9d5d6b3/AlphaMissense_gene_hg38.tsv.gz
@@ -0,0 +1,3 @@
+version https://git-lfs.github.com/spec/v1
+oid sha256:f962ac005fbee1508151625464b952876ced8d21231627942159d944b2b1bd39
+size 1569
diff --git a/excerpt-data/521f5677c9d5d6b3/url.txt b/excerpt-data/521f5677c9d5d6b3/url.txt
new file mode 100644
index 0000000..7574e01
--- /dev/null
+++ b/excerpt-data/521f5677c9d5d6b3/url.txt
@@ -0,0 +1,3 @@
+version https://git-lfs.github.com/spec/v1
+oid sha256:5ee9e2f439cea6047377e83f67124fdca50c925bc64a588fc03af4991a608bbf
+size 79
diff --git a/excerpt-data/c47fb6a5c19a1ec2/AlphaMissense_hg38.tsv.gz b/excerpt-data/c47fb6a5c19a1ec2/AlphaMissense_hg38.tsv.gz
new file mode 100644
index 0000000..9cd6015
--- /dev/null
+++ b/excerpt-data/c47fb6a5c19a1ec2/AlphaMissense_hg38.tsv.gz
@@ -0,0 +1,3 @@
+version https://git-lfs.github.com/spec/v1
+oid sha256:c97ac023f6607dbd402e33dfea71118301b5d965dc758f7760dec4e3a9f40ccf
+size 1141
diff --git a/excerpt-data/c47fb6a5c19a1ec2/url.txt b/excerpt-data/c47fb6a5c19a1ec2/url.txt
new file mode 100644
index 0000000..2d98465
--- /dev/null
+++ b/excerpt-data/c47fb6a5c19a1ec2/url.txt
@@ -0,0 +1,3 @@
+version https://git-lfs.github.com/spec/v1
+oid sha256:4fdab28332daf40f4567d25b03de660c6db2fe073ed156f7c58c332d78c12367
+size 74
diff --git a/rules/work/annos/seqvars/alphamissense.smk b/rules/work/annos/seqvars/alphamissense.smk
new file mode 100644
index 0000000..fca5d2f
--- /dev/null
+++ b/rules/work/annos/seqvars/alphamissense.smk
@@ -0,0 +1,15 @@
+## Rules related to the AlphaMissense scores
+
+
+rule annos_alphamissense_download:  # -- download AlphaMissense data
+    output:
+        tsv="work/download/annos/alphamissense/1/{genome}/AlphaMissense_{genome}.tsv.gz",
+        tsv_md5="work/download/annos/alphamissense/1/{genome}/AlphaMissense_{genome}.tsv.gz.md5",
+    shell:
+        r"""
+        wget --no-check-certificate \
+            -O {output.tsv} \
+            https://storage.googleapis.com/dm_alphamissense/AlphaMissense_{wildcards.genome}.tsv.gz
+
+        md5sum {output.tsv} >{output.tsv_md5}
+        """
diff --git a/rules/work/genes/alphamissense.smk b/rules/work/genes/alphamissense.smk
new file mode 100644
index 0000000..b8a1a50
--- /dev/null
+++ b/rules/work/genes/alphamissense.smk
@@ -0,0 +1,15 @@
+## Rules related to AlphaMissense per-gene scores
+
+
+rule genes_alphamissense_download:  # -- download AlphaMissense per-gene scores
+    output:
+        tsv="work/download/genes/alphamissense/1/AlphaMissense_gene_hg38.tsv.gz",
+        tsv_md5="work/download/genes/alphamissense/1/AlphaMissense_gene_hg38.tsv.gz.md5",
+    shell:
+        r"""
+        wget --no-check-certificate \
+            -O {output.tsv} \
+            https://storage.googleapis.com/dm_alphamissense/AlphaMissense_gene_hg38.tsv.gz
+
+        md5sum {output.tsv} > {output.tsv_md5}
+        """